Sometimes I wonder if our health is a political pawn .
Consider, for instance, the implications of an effective treatment
for cancer. Might this be perceived in various circles as a diminishing of the nuclear deterrent.
A strategic advantage if one group had this whilst another didn't.
At the very personal level, which many of us seldom approach,
politics and the machinations of those who have a contrary agenda
to your well being are the last things you want to confront.
Few might be aware of this; some decades ago the WHO were
promoting measures to curb the world's population.
A disaster, especially for the worlds unacknowledged minorities.
Now imagine an individual from this minority, how difficult is it
going to be to aspire to life extension in the sense that we're considering this.
Anyway a bit of reality and a bit of paranoia.
On Tuesday, July 7, 2020 at 7:02:49 PM UTC+12, sciw...@gmail.com wrote:
Sometimes I wonder if our health is a political pawn .
Consider, for instance, the implications of an effective treatment
for cancer. Might this be perceived in various circles as a diminishing of the nuclear deterrent.
A strategic advantage if one group had this whilst another didn't.
At the very personal level, which many of us seldom approach,
politics and the machinations of those who have a contrary agenda
to your well being are the last things you want to confront.
Few might be aware of this; some decades ago the WHO were
promoting measures to curb the world's population.
A disaster, especially for the worlds unacknowledged minorities.
Now imagine an individual from this minority, how difficult is it
going to be to aspire to life extension in the sense that we're considering this.
Anyway a bit of reality and a bit of paranoia.This does seem to be related.
Today I was watching flying videos on youtube.
I was interested in the instrumentation in today's aircraft, mostly computerized.
The pilot relies upon these to chart a safe course through weather, his journey, aircraft parameters.
This is all necessary for a safe flight, autopilot is .available once the correct circumstances have
been establihed.
If only genomics,, protein assembly, drug discovery was presented in a similarly comprehensible
and interactive manner, especially considering that lives depend upon this too.
Concerning Alphafold 2.
This is considered an advance in protein folding prediction
by many.
https://www.nature.com/articles/d41586-020-03348-4
Some however say that the intervening steps in the
folding need to be made apparent, in an accurate manner.
From https://geneonline.news/en/2020/12/11/spotlight-alphafold-maybe-this-centurys-biggest-breakthrough-in-computational-biology/
"The predicted structure from AlphaFold2 is a snapshot of the protein’s conformation, much like a crystal structure and not dynamic modeling of
the protein folding."
The latter is usually the domain of the standard computational
molecular dynamics.
Understanding an intervening configuration of the Covid 19 virus
spike was crucial in the development of a vaccine.
https://pubs.acs.org/doi/10.1021/acs.jpcb.0c03716#
Computational Molecular Dynamics continues to be limited by the
available hardware, especially when modelling large molecular
complexes.
https://par.nsf.gov/servlets/purl/10100859
All of this initially appears to be a software issue, whereby
we merge different approaches and cross reference the results,
or train a larger system that utilizes different modules.
The code for Alphafold 2 is yet to be made publicly available.
General Reference
Folding https://www.hpcwire.com/2020/10/14/how-foldinghome-identified-and-visualized-sars-cov-2s-weak-spots/
https://www.nature.com/articles/s41401-020-0485-4
https://towardsdatascience.com/alphafold-2-explained-a-semi-deep-dive-fa7618c1a7f6
http://occamstypewriter.org/scurry/2020/12/02/no-deepmind-has-not-solved-protein-folding/
CMD
https://ieeexplore.ieee.org/document/6375578 https://iopscience.iop.org/article/10.1088/1742-6596/180/1/012028/pdf https://www.hpcwire.com/2020/07/15/heffte-highly-efficient-fft-for-exascale/
Folding https://www.blopig.com/blog/2020/12/casp14-what-google-deepminds-alphafold-2-really-achieved-and-what-it-means-for-protein-folding-biology-and-bioinformatics/
https://www.skynettoday.com/briefs/alphafold2
On Sunday, August 30, 2020 at 2:22:41 PM UTC+12, sciw...@gmail.com wrote:
On Tuesday, July 7, 2020 at 7:02:49 PM UTC+12, sciw...@gmail.com wrote:
Sometimes I wonder if our health is a political pawn .
Consider, for instance, the implications of an effective treatment
for cancer. Might this be perceived in various circles as a diminishing of the nuclear deterrent.
A strategic advantage if one group had this whilst another didn't.
At the very personal level, which many of us seldom approach,
politics and the machinations of those who have a contrary agenda
to your well being are the last things you want to confront.
Few might be aware of this; some decades ago the WHO were
promoting measures to curb the world's population.
A disaster, especially for the worlds unacknowledged minorities.
Now imagine an individual from this minority, how difficult is it
going to be to aspire to life extension in the sense that we're considering this.
Anyway a bit of reality and a bit of paranoia.This does seem to be related.
Today I was watching flying videos on youtube.
I was interested in the instrumentation in today's aircraft, mostly computerized.
The pilot relies upon these to chart a safe course through weather, his journey, aircraft parameters.
This is all necessary for a safe flight, autopilot is .available once the correct circumstances have
been established.
If only genomics,, protein assembly, drug discovery was presented in a similarly comprehensible
and interactive manner, especially considering that lives depend upon this too.
Of note
Exosomes
pubmed.ncbi.nlm.nih.gov/32759948
There are other factors that are known and have yet to be
addressed.
The late Joshua Lederberg, former president of the New York Academy of Sciences, and Nobel
recipient, was well aware of Exosomes; many decades ago.
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