• As a very simple source of samples to screen for longevity chemicals, t

    From Treon Verdery@21:1/5 to All on Tue Oct 11 21:22:05 2022
    making homogenate and concentrate of each then feeding them to groups of 11 zebrafish, 100 groups provides p<.01 on whether the concentrates are longevizing, or also behavior changing, this would likely find the pineal gland, but the benefit is to find
    other new brain areas associated with longevity, and their products which are useable as longevity drugs, along with brain areas glia are also tested,

    Notably some areas of the brain and body are least different between supercentenarians and 16 year olds and 8 year olds, administering tissue concentrate (such as mass fraction or electrophoretic fraction) of those minimal senescence tissues to zebrafish
    could find new longevity and wellness chemicals that can be upregulated at other tissues to cause those tissues to have minimal change throughout living, that makes new longevity and wellness drugs or gene therapies or also germline genetic modifications,
    also the tissue concentrates of the least changing tissues could be tested as longevity drugs at zebrafish and then marmosets

    Longevity drug, the least changing proteins and peptides at circulatory system fluids between supercentenarians and 16 year olds or 8 year olds could lead to finding the physiology of least senescence at tissues and cells when the least changing effect
    is traced back to particular cell and tissue types that put the physiochemicals at the circulation, then once the genetics of least change are found they can be used to upgrade other kinds of cells, making as many types of cells possible to be minimally
    changing with age, minimally changing heart cells and vasculature cells could preclude heart disease and cardiovascular disease, minimally changing neurons could be verified at marmosets as nondeleterious to learning and memory, as well as preserving or
    having no effect on personality, it is possible that minimizing neuronal change with 8 years old or 16 years old as a preserved baseline causes adults to have notably more fluid intelligence like children, this also contributes to having a fresh lively
    mind as a supercentenarian

    It/il/mirror pattern usage, preserving personality regardless of recruitment, physiochemically preserving the personality at 4.5 years of age could preclude the effects of pattern recruitment on personality, physiological parents could then also choose a
    personality for their children, i favor light triad personality function,

    The chemicals or multiple physiochemical networks that cause center high velocity growth at the / graph of logarithmic phase growth during human (Homo sapiens and branch species growth) embryo and fetal growth could be found, then mid logarithmic curve
    velocity could be utilized at artificial organ growth,

    a completely new artificial organ, or just an upgrade to bone marrow or lymph nodes, could exist just to produce stem cells, making it so there are orders of magnitude, perhaps a million times more stem cells at the circulatory fluid, these stem cells
    replace cells that are beneficially terminated with apoptosis if they deviate from youthful phenotype, the big surplus of stem cells is a longevity technology and coninued juvenescence of the body technology, interestingly it may be possible to turn up
    the body's anticancer defenses to do 20 times more iffycyte apoptosis, as the new big surplus of stem cells replaces the even slightly precancerous or cancerous cells, that could cause much less cancer as a disease to occur, ways of reducing cancer at
    mice like multiple copy number P53 genes are published, so upregulating that after a person has attained their full height is a way to reduce cancer at humans (Homo sapiens and branch species) with the million times stem cell amount replacing the
    stronger multiple P53 terminated cells

    Yeast have some genetic overlap with humans, perhaps 29%, so using a mutagen at yeast, and Green or blue fluorescent protein accumulation to indicate lifespan, select and reculture the longest lived yeast to make yeast that live two to 16 times longer,
    notably 29% of the new and modified longevity genes are shared with humans and marmosets, genetically engineer mice and marmosets to make the improved longevity genetics to verify a longevity benefit and an absence of deleterious effects at variously the
    entire group of shared yeast longevity effects as well as subgroups, then, at the most longevizing subgroups have volunteers receive gene therapy to verify greater longevity at humans (Homo sapiens and branch species)

    Process a database of all fungal genomes including mushroom producers and varied microscopic fungi like yeast to find the fungal genome most similar to the human (Homo sapiens and branch species) genome, then if mushroom producers have more shared human
    genes find testable explanations for this finding,

    Stochastic input at neural networks during training analogous to adding stochastics to images to resolve them could cause more effective neural network learning/programming

    Has anyone tried making an analog neural network instead of a digital one with field effect transistors and analog amplifier semiconductors, the training could occur at femtoseconds,

    Analog neural network imaging IC, utilize picosecond or femtosecond predict an actual physiological neuron, then duplicate a trilion times to nonsentiently model an entire human (Homo sapiens and branch species) brain, indium phosphide has published 7
    trillion units per second capacity, supporting this technology

    EEG cap or circlet that feeds back the different electrodes to two or more 20th century style EEG cap map locations, so you could have a diode at the connectors such that EEG of frontal lobes is connected, with or without amplifier to occipital area, or
    occipital area EEG electrode positions drive frontal lobe EEG skin surface electrodes, from reading i perceive the occipital visual processing area has nonnarrative sentience, presence of being, so driving the cognitive frontal lobes from this area could
    cause greater see it, instantly know it, react appropriately to it forms of sentience to be stronger, similarly driving the occipital lobe from the frontal lobe with or without an electrical amplifier could cause people to experience visual recognition,
    influenced by cognition, Also for each 20 EEG map electrode positions there is a large plurality of different two or three electrode sets that can be linked together with diodes or optional electrical amplifiers to make them unidirectional,

    Reduce mental illness, drive EEG associated with happiness or just EEG playback of happy hypomanic persons to treat depression, to treat schizophrenia use monozygotic twins EEG where only one is schizophrenic to 1) find EEG of schizophrenia, 2) play the
    EEG of the well twin at at the brain of the scizophrenic twin to find out if there is measurable improvement, 3) with measured improvement create a synthetic EEG waveform that is even more effective

    Keratin reactive (michael reaction like transparent henna) electrical conductor that lasts months, transparent, at scalp installed with shampoo, reduces skin resistance dozens or hundreds of times, facilitating EEG technologies

    The nucleus accumbens although far from the head surface does have a pattern of EEG electrodes that can sense its electrical activity, playing EEG of pleasurably high people, on a variety of recreational drugs back to the nucleus accumbens of people not
    on recreational drugs may make them feel high, educational software associates practice exercises and getting them right with stimulating nucleus accumbens EEG playback, rewarding learning at a 1 second positive reinforcement completion and reward
    interval, also this could work to reinforce textbook learning by EEG sensing of learning from reading, active thoughtful reading, at the textbook, and then delivering an EEG reward a couple of times a page, at a math or sciences textbook, a computer
    camera observing the eyes could tell when the person is foveally focused on an equation, and simultaneously has the EEG of thinking, then adminstrate a noniterruptive nucleus accumbens EEG reward, the effect is that the person learns more equations, even
    more enjoyably

    Polyphosphosphonium NMN could be a new wellness longevity drug, I read that the polyposphonium PPP concentrates things at the mitochondria and the nmn increases the amount of atp that gets made, polyphosphonium DHA could put more beneficial DHA at the
    mitochondrial membranes which are numerous, some different PPP-lipid could have even better effects like mitochondrial membrane lipids that are in coldwater organisms, lutein makes drosophila live 63% longer, PPP-lutein could be tested to see if it makes
    mice live longer, and if so which is better Skq1, SkQ1-PPP, PPP-lutein at longevizing mice singly or in combination, i do not know if there is a longevity technology based around 400 year lifespan tortoise' mitochondria or bowhead whales mitochondria,
    but replacing the mitochondrial DNA of mice with 400 year tortoise and bowhead whale mitochondrial DNA could find increased longevity effects, its also possible to copy the mitochondrial genome, both nuclear DNA and mitochondrial DNA of bonobos into mice
    to see 1) do the mice live longer, 2) if there are any synthetic mitochondrial gene substitutions that are on longevity trend, but even moreso, causing even greater longevity at mice

    Epigenetics of nuclear mitochondrial DNA, such as acetylation could beneficially make more mitochondria at every body cell, this could be verified, if it works, as rejuvenating any and all body cells as well as increasing lifespan

    You could measure how similar phenomena are by how minimal, in an integer number of steps, the retraining of an NN to recognize both phenomena/images/data is, then, as a way humans can be more creative, the humans can find relations between the two most
    unsimilar unprocessable data objects, coming up with a new connection, this gives humans something to voluntarily do as computers and AI gain greater and greater ability

    I do not think this works because i used Wolfram Alpha to factor some big numbers and the digit count of the factors was the same or higher than the digit count of the original number: Add a residue assistant factoring, and compression: what assistant
    number of 20 digits when added to a 192 bit string makes it factor, more quickly into smaller numbers of fewer digit factors, negative numbers also ok, then store factors and assistant digits together as compressed form of the 192 bit string, wikipedia
    says a 2019AD Graphics coprocessor can factor 192 bits in 100 milliseconds, so, going with the idea that is 11 times stronger using GPU and CPU improvements or the cloud, each 8000 bits/1000 bytes of text can be factored in 3-5 seconds to a compressed
    form composed only of factors, those factors can be laid out in 100 different digit orders, each of those compressed, and the briefest among them used to represent the 1000 bytes of data, expansion from multiplying the factors is very fast, uses include
    serving compressed pages and video on the internet, and storing them in less space, with compression to factors

    Intel has a field programmable gate array product that can function at 8.5 GHz, underlaying a hyperspectral imaging chip the FPGA could directly process data inline, and with hardwired resolvable patterns, or neural network arrangements lessening
    computational load on the CPU which could always ask for just the straight data if it liked, the effect is that the imaging FPGA chip can see in separate timespans, detecting vibration and mathematically compensate for it, at industrial and companion
    robots as well as phone cameras this gets rid of blur, and at robots creates microseconds to multiple seconds of movies that teach an AI or neural network a skill, noting repeat behaviors at the observed system at different timescales, FPGA directly
    vertically inline with hysperspectral imaging can be used with earth sensing applications from space as well as astronomy outside of earth,

    People visually see road shimmer virtual images above some degrees F, can a computer imaging device see road shimmer at cooler temperatures like -1 to 68° F? Are there vehicle safety advantages to seeing other cars that far ahead?

    Very basic and likely has already been tried but noting germanium .7 volt transistor voltage and silicon 2.7 volt transistor could a ratio of the two at an alloy be used to make a 1.3 volt switching voltage transistor? Regular dopants would be used, this
    halves the energy used by a computer chip, saving money and keeping it running cooler, which then allows for higher clock speeds and faster computation, valuably, the Germanium silicon alloy, at some ratio could be a drop-in replacement for silicon at a
    wide plurality of existing semiconductor manufacturing processes,

    Microwave 90 degree turn, evanescent wave, wax prisms edit forbidden zone/bandgap, but do this at minute transistors instead

    Are volts volts or is electromotive force actually a distribution of different EMF with a group average called volts, if EMF is actually a distribution then technology that makes a very high narrow distribution from regular power supply volts makes a
    novel kind of electricity that acts different in everything from integrated circuits to generator windings to electroplating and battery recharge, large enough capacitors could possibly act as a high pass bandpass filter for emf so ac to capacitor group
    of like 8, with a different ac pulse at each capacitor, then a diode then an inductor could assemble high narrow emf distribution volts from AC

    Satellite dish or nonfocal cone painted with a paint that absorbs a bunch of other frequencies than the preferred microwave communication frequency, little metal squiggles in white paint could do this, it benefits satellite internet from removing
    background signal

    Thaw rate of frozen sperm at human baby design eugenics kit available at mini marts, department stores and online could be controlled by 3-4¢ thaw tube with ir led, fingernail sized hologram beamshaper film, and 1¢ button battery and polymer tube that
    holds thawed sperm

    To find ways to make sperm freeze dryable freeze dry 1-100% of the water out then see which ones warm and hydrate up to be egg seeking swimmers, if only 1/4 rehydrate and swim after experiencing 70% dehydration, then they can study which systems are
    giving out in the 70%, also at the different 70% survive dehydration they can have the living ones rehydrate with oxygen carrying perfluorocarbons, then repeat that dilution of remaining water with perfluorocarbon until a revivable, dehydrated but wet
    with blood replacer perfluorocarbons sperm with a 400 day shelf life (unrefrigerated or refrigerate) is produced

    Reduced methionine breastmilk that causes 40-60% greater longevity at the nursed progeny, when mice are calorie restricted during their first 2 days, the mousetime equivalent of about 60 human days, they live 40-60% longer without any other intervention,
    the caloric restriction effect is associated with reduced methionine, so, germline genetically engineering or epigenetically engineering a breastmilk with minimal methionine content causes 40-60% longer lifespan from yummy drink as much as you like
    breastmilk without caloric restriction at the baby, after verifying methionine reduced breastmilk is both longevizing and nondeleterious at mice and marmosets it can be tried at human breastmilk,

    The human body both uses and metabolizes methionine, upregulating with gene therapy or epigenetics the gene that makes the methionine metabolizer hat could be called methioninease could reduce the amount of methionine strongly, and be measured as
    increasing longevity

    another possibly longevizing thing is methionine reduced diet during pregnancy, causing much less (1/10th) methionine to reach the fetus, also with verification of longevity effects and absence of deleterious effects a minimal methionine infant formula
    could be produced for use during the first 60-90 days after parturition, the formula fed babies could be longitudinally followed to 1st grade and cognitively measured to verify absence of anything deleterious and possibly find advantages,

    an improvement to infant formula, along with minimized methionine is that it could have an ingedient, like a fiber, that slightly gels with stomach acid, and while making all its nutrients fully available take 29% longer to digest and pass through the gi
    tract, causing 29% less feelings of hunger at babies that could result in crying, i think both babies and physiological parents enjoy less crying

    One author suggests that calorie restriction turns off an aging program, if true then monozygotic twin mice could have their mRNA characterized and the difference between a fasting twin and a nonfasting is measured, RNA drugs then imitate the effect/
    modulate the effect/epigenetically modify the effect of non calorie restricted mRNA mz twins, this then narrows to the smallest RNA drug suite or gene therapy that mimics caloric restriction while still letting people eat as much as they like

    Treatments and cures for headaches, wikipedia notes that anesthetizing a nerve with an analgesic swab up the nose is very effective, "Blockade of the ganglion with local anesthetic, clinically referred to as a ‘sphenopalatine ganglion block’ may be
    performed transcutaneously with a small needle, or topically via the nose with local anesthetic soaked swabs. The topical sphenopalatine ganglion block is used for treatment of persistent migraines and cluster headaches, demonstrating relief within 10-20
    minutes. " so improve that with a michael reaction (transparent henna) linked anesthetic molecule that resides on the nose mucosa skin a month, that gets rid of headaches all month
    Another treatment that gets rid of many headaches is aspirin or naproxen attached to a body area localization peptide as well as a cell membrane transporter peptide or moiety, this could reduce the interval between a liquid dose of naproxen or aspirin
    and headache relief by several minutes

    A peptide that inhibits cyclooxygenase 2 could relieve headaches very rapidly from buccal (mouth) absorption, just chew on the liquid capsule releasing it, swish it around the mouth and get much faster relief than a pill, the cox-2 inhibiting peptide (
    published) could be attached to a cell membrane passing peptide for even more rapid absorption

    Laser sterilization around the dwelling, workplace, school as longevity specific pathogen free longevity mimic, sterilize some things with uv roomba, multiangle on wall sensors and uv volumetric light, fomites, picosecond lasers, Thz or uva sensationless
    palm/hand surface sterilization, children's room and crib bacteriocidal light when unoccupied

    Ultraffordable muon and particle production with a fiber laser engineered form, 1) make a fiber laser and use it to laserpulse a metal foil to make muons and other particles,2) instead of that have the metal atoms actually inside the fiber laser, at a
    fiber laser, possibly a polymer fiber laser with periodic metal atom saturations or quantum dot sized metal inclusions that in-fiber metal is laser percussed to make muons and particles, most of the light gets through, and external pumping of the fiber
    laser beyond the metal reraises the laser power to percuss the next internal metal area, if a polymer fiber laser is possible a 1 cm diameter spool of polymer fiber laser where the winding style and the periodicity of the metal create an area where,
    because the metal areas are aligned on the spool a superconcentration of muons or other particles is produced, kind of like a muon or other particle beam,

    Single project 3$ / watt RF muon making/contributing source, could be 3¢ a watt with mass production at alibaba, but now i think it might not work, see wiggler at wikipedia,

    use muon producers to make what i perceive are ultra high magnetic field muonic muontricity magnets for generators and motors, 2 microsecond muonic duration is 435 meters of winding wire before muon transforms to electron, long enough to make generator
    and motor windings , the way muons are 207 times more massive than electrons provides novel effects at muontricity, perhaps causing useful "heavy current" that could be used at ballistic transistors, the heavy current could also increase the equivalent
    of amps, but at thinner wires, making heightened magnetism with smaller magnets, (hard disk write heads) maybe, there is so much i do not know about muontricity like is a moving conductor in a muontricity field the kind of thing that at stp vacuum plasma
    muonMHD can do, if so then steering the plasma around creates separate lines of conductible muontrcity that can connect to metal contacts on the sides of the plasma container, providing muontricity conductive pathways with current, muontricity at 200
    times greater mass could exhibit 200 times less quantum tunneling, making smaller transistors possible, also 200 times mass at the muontricity could provide more muonEMF per columb/mole of muons

    Muontricity and neural networks, the actual wiring distance is much briefer than 435 meters of nondecay muon muontricity, the neural network semiconductors could be all new muontricity particular semiconductors like, just possibly, Ca, Mg, Sr, Li, Be
    doped with whichever elements can be used to dope a muontricity semiconductor, findable by testing all the stable elements at a PN diode configuration, perhaps 82K different possible things to test,

    Muonic catalysts, Muons can surround a nucleus to make entirely new shapes of mounOrbitals, with different energy levels and thus do completely different chemistry, unless i misunderstood, wikipedia says muons are also 200 times smaller than electrons(?),
    if that is true then perhaps really different chemistry and orbitals can occur, notably at catalysts, at a muonic catalyst fresh muons would be conducted or sprayed (compare e-beam spray to muon beam spray) to the surface of positive ions, reducing them
    to catalyst muon metals, which then catalyze reactions, at a fiber laser produced muon source this could be much cheaper than some catalyst metals if the muonic catalysis metals nuclei happen to be cheap, one area of catalysis that could be especially
    lucrative and valuable are muonic catalysts that work on CH4, and if as wikipedia says muons are 200 times smaller than electrons perhaps the CH4 stability could be breached by having a big plurality of muonic catalyst atoms nestling easily between the
    CH4 carbon and hydrogen, doing stuff that causes the CH4 to disintegrate and recombine into more valuable fuel alkanes

    Muon deep imaging already exists, seeing through tens of meters through minerals, combined with a quantum entangled quantum camera like the one in NewScientist magazine that sees a figurine, the non return path quantum entangled muon illumination beam
    could see much farther than x rays into or through the ground, one application is steering a horizontal petroleum drilling head, another application is social companion robots that emit some quantum camera muons and can see through walls and building
    floors and celings

    Besides RF oscillators or wigglers, which i dont think works, another cheap way to produce muons is laser pulses on foil, a cm sized foil, undergoing 100 different wavelengths of laser percussions simultaneously might be equivalent to a one meter foil,
    and at 235nm has more than 33 million separate laser percussion spots reachable with a grating, pulsed each 1 femtosecond the 1 cm foil makes 1*10^15batches of 33 million laser dots, or 3.3*10^22 muon generating events per second, thats about a twentieth
    of a mole of muons, enough to run ballistic high speed transistors with or provide muontricity to charge a generator or motor winding, of interest to computer applications entirely new semiconductors, diferent atomic elements and dopants can be used to
    make muontrcity semiconductor devices

    soliton lasers improve laser foil muon and other particle generation

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