then advertise to talk to a babysitter, and ask if you can do her overflow or when she is not available, possibly 7-3 during school year. Pay her a comission for every hour of babysitting that occurs, and have her collect the money and give it to her
favorite charity, with her reserving her comission out of the earnings.



Longevity technology:



fisetin is a senolytic. tyrosine sulfate is not metabolized by the liver. It is possible although unknown to me that fisetin sulfate could possibly be senolytically active while having a long sustained plasma half life as, like tyrosine sulfate it
would be gradually excreted as urine. I do not know if sulfates pass through exterior cytomembranes or pass epithelial cytes, it is possible that putting an enzymatically dividable linker molecule like a ribose, a two mer (unit) peptide or even a acetyl
link like the one at sucrose that goes between the dextrose and fructose between the sulfate part of the molecule and the fisetin part of the molecule could cause much greater plasma half life, but be able to have the fisetin separate to be an active
senolytic at the cytoplasm because of enzymes endogenous to the cyte’s cytoplasm; as a possible localization opportunity it is possible that some kinds of cytes have very different endogenous enzyme concentrations or types than other cytotypes, so the
long plasma halflife version of fisetin would cause fisetin sulfate to soak in all over the body with a multi hour or even multi day plasma half life and only divide from its sulfate at the linker site at a particular kind of cyte with the right enzyme,
perhaps a deacetylase or an aminoacidase. Or an opportunity: if the linker molecule is ribose, NR, NMN or something like coenzyme Q10, then it is possible the amount of enzymatic activity at the cyte will be directly related to the number and activity of
the mitochondria at that cyte: localizing fisetin to high mitochondrial number or also high mitochondrial metabolic output could concentrate a senolytic at a particularly active tissue, localizing the senolytic effect



fisetin palmitate or dasatinib palmitate as a super long plasma half life senolytic, palmitate depot drugs last, I perceive as long as 3 or 6 months from one injection, so compared with what might be a 1 hour human plasma half life at fisetin the fisetin
palmitate would be at active drug strength for 4320 hours, so 3 orders of magnitude longer lasting senolytic activity. Palmitates possibly just attaches a C16cooh to some part of the fisetin or dasatinib (dasatinib actually has an ethyl with an -oh on
the distal part that might be replaceable with a C16cooh as kind of similar from my uninformed perspective) or another senolytic, the fisetin might still work as quercetin looks like fisetin and is one -OH different and some other -OHs are like a
different angle of para on a benzene, and quercetin kind of works as a senolytic, noting dasatinib with quercetin published effective senolytics.



longevity technology:



So, noting magnesium sulfate (epsom salt) makes the blood brain four times less permeable should I take it because phenylethylamine blood pressure effect raises my blood pressure and because pressurized osmotics at the blood brain barrier? I could even
just take it the day of phenylethylamine



It would be nifty to find out if magnesium sulfate had an effect on placenta permeability, if it does it could be a mass production veterinary drug that possibly benefits mammal fetuses, imaginably 1-2 per 100 mammals. a thing from wikipedia supports
magnesium sulfate as a possible well pregnancy drug, “Magnesium sulfate is effective in decreasing the risk that pre-eclampsia progresses to eclampsia.[11] IV magnesium sulfate is used to prevent and treat seizures of eclampsia. It reduces the systolic
blood pressure but doesn't alter the diastolic blood pressure, so the blood perfusion to the fetus isn't compromised.”



The four times less permeability at the blood brain barrier along with the blood pressure reduction makes me think that magnesium sulfate (epsom salts) could reduce the risks of phenylethylamine, but, this onlinbe thing says it is only 2 units, “people
receiving a median of 368 milligrams (mg) of magnesium a day for an average of three months had overall reductions in systolic blood pressure of 2.00 millimeters of mercury (mm Hg) and diastolic blood pressure of 1.78 mm Hg.”



Dose: “intramuscularly (6 g loading dose followed by 2 g/h)” oral constipation dose, “2 to 4 level teaspoons dissolved in 8 ounces water orally

-Repeat dose in 4 hours if needed.

Maximum dose: 2 doses per day”



a million cytes processed in a few hours (2015 AD), “The "µ" stands for the microcapillary glass slide that holds the protein samples. The slide is roughly the size and thickness of a penny, yet in that space a million capillary tubes are arrayed like
straws, open on the top and bottom.

The power of µSCALE is how it enables researchers to build upon current biochemical techniques to run a million protein experiments simultaneously, then extract and further analyze the most promising results.”, “The slide bearing these million yeast
or bacteria, and the protein variants they produce, is inserted into the µSCALE device. A software-controlled microscope peers into each capillary and takes images of the biochemical reaction occurring therein.”

a different system does 100k yeast per second, or 10 seconds to process one million yeast, “To show the system’s utility, we demonstrate high-throughput image-based screening of budding yeast and rare breast cancer cells in blood with an
unprecedented throughput of 100,000 particles/s” https://www.pnas.org/content/109/29/11630

when using a million yeast to see if any of the protein parts of something like a 200 year old rockfish’ tissue causes yeast to live longer it is possible that the

It is possible that yeast engineered to produce more fluorescent protein each 24 hours could be detected as to their lifespan with the very oldest yeast producing the most fluorescence, then you would just coat a freeze fractured, possibly freeze dried
micropowder of a 200 year old rockfish’ tissue or a freeze dried freeze fractured sample of filtrate from seawater with the fluorescent yeast, and wherever the camera detected a one per million yeast longevity event the eentsy portion of freeze dried
freeze fractured tissue the yeast was on could be isolated, and the chemicals and proteins in it characterized to find proteins, peptides or other chemicals that caused the one per million yeast longevity event. It is possible that if 11 to 100 yeast
grow on each microfragment of the biological library of rockfish tissue or ocean water filtrate then the yeast could be isolated while alive and measured as to things like the mRNA or other cytoprocesses that caused them to be unusually long lived. The
blob of longevity chemical releasing tissue could also be dug out of the array to find and show the organism or sample that caused the longevity effect at the yeast.

Numerous longevity technologies at the notebooks make use of screening a library for new longevity producing molecules, noting the 1 million yeast screened per 10 seconds a camera system that finds and isolates the most fluorescent, from having lived the
longest, yeast seems possible

.

Longevity drugs:

Fifty‐three lifespan experiments, involving 30 test agents, have been initiated in the first 11 years of the ITP. Significant effects on longevity, in one or both sexes, have been published for 6 of the tested agents: aspirin (Strong et al., 2008),
nordihydroguaiaretic acid (NDGA) (Strong et al., 2008; Harrison et al., 2014), rapamycin (Harrison et al., 2009; Miller et al., 2011, 2014), acarbose (ACA) (Harrison et al., 2014), methylene blue (Harrison et al., 2014), and 17‐α‐estradiol (17aE2) (
Harrison et al., 2014).



17‐α‐estradiol (17aE2)

Beginning at 10 months of age, male and female mice were fed chow containing 17aE2 at a concentration of 14.4 ppm (17aE2). As shown in Table 1 and Figure 1, median lifespan increased 19% in male mice, calculated from data pooled from the three sites (P <
0.001). The effects of 17aE2 were significant at all three sites, at P < 0.003, with increases in median survival of 26%, 9%, and 23% at TJL, UM, and UT (Fig. S1, Supporting information). The age at which 90% of the mice had died increased on average by
12% (21%, 8%, and 8% at the three sites;

dose: 14 ppm in mouse food, or .014 Grams per Kg of food, it is unknown how much food mice eat every 24 hours. It is possible they eat 5g of food every 24 hours which would be a human dose of 2333 mouse measl per human per day, or 11.665 Kg of food
equivalent aE2 per human, or 163.3 mg of 17aE2 per human per day, or with mouse compensation number, 13.6 mg aE2 per day

17aE2 is at alibaba.com



Rapamycin with metformin: Males given Met/Rapa had a 23% increase in median longevity

food: 14 ppm rapamycin, 1000 ppm metformin

163.3 mg of rapamycin per day for a human, with mouse compensation number, 13.6 mg per day at a 70 kg human.

1000 mg per kg, 30 gram mouse, 5 grams of food every 24 hours is 11.66 grams of metformin per human, with mouse compensation number, .972 grams of metformin per day per human.



NDGA: Nordihydroguaiaretic acid (NDGA)

In a previous study, we tested the effects of NDGA on survival of male and female UM‐HET3 mice at a dose of 2500 ppm and reported that median lifespan was increased in males by 12%, with no benefit in female mice (Strong et al., 2008). In the earlier
study, 9% of male control mice were alive at the joint 90th percentile age, compared with 13% of NDGA‐treated males (P = 0.12).

Acarbose (ACA)

Beginning at 16 months of age, mice were fed chow containing 1000 ppm ACA. The results are shown in Figure 6 and Table 2 with site‐specific statistics in Table S3 (Supporting information). Pooling the data across sites, there was a significant increase
in survival for male mice treated with ACA, with a 6% increase in median lifespan and a significant 12% increase in maximal lifespan

a peptide: https://interestingengineering.com/12-innovations-that-could-make-reverse-aging-a-reality “testing pNaKtide, a synthetic peptide that could further reduce risks of illness and the effects of aging.”, “The study saw researchers
successfully reverse the biological state of the brain in mice aged 12 months and 18 months. The test mice were treated with THC in small, non-intoxicating doses for a period of four weeks. They were noted as out-performing the control group who had been
given a placebo, and were shown to have similar cognitive performance to younger mice. This could mean that non-intoxicating THC treatments might allow older humans to regain youthful levels of cognition.”

Two days before July 27th, 2019

A drug that makes people more big five psychology test: conscientious (kind of like myers briggs J) could be a drug that causes greater success are various kinds of things, a successtropic. Some social efforts could be replaced by prescribing mentally
well people in the bottom 30th percentile of doing well successtropics to voluntarily take. One possibility is looking at the fMRI and positron emission tomography of people at the 90th percentile of doing well and seeing if they have more or different
activity at various locations and many different kinds of neurons and neurotransmitters. It could be brain system activation thing as well though, so perhaps computer software or virtual reality could do it.

Acarbose is published as causing 9 or 10% longer lifespan in mice at 1 part per 1000 in mouse food, wikipedia says that it is produced as several versions at one pill, “WHere was the structure for acarbose sourced? I think the stereocenters might be
wrong. I have a feeling it was sourced on PubChem. There are MULTIPLE acarbose structures on PubChem. See here. The think the correct stereo is as shown here oChemSpider. However, this is my opinion and it needs confirming. Help.--ChemSpiderMan (talk) 00:
30, 25 January 2008 (UTC)

Yes, I used PubChem as a source at the time. I'm not sure of the stereochemistry; as you just said, help :) Fvasconcellos (t·c) 00:57, 25 January 2008 (UTC)

The information from Bayer is here it seems its sold as a mixture of anomers” So perhaps just one of the versions is more active at causing longevity.



It was pleasant to find out that liposomes transport things inside them to the lympathic system, where they have more biological activity that going to the liver through a vein, “Lipid-based nanoparticles

(formulation-derived)

Administration of a single capsule of long-chain lipid can stimulate significant lymphatic transport of drugs.

- Solid lipid nanoparticles

- Self-nanoemulsifying drug delivery systems

- Emulsion

- Liposomes

- Effective carriers for drugs

- Stimulators of chylomicron production

The effect of the formulation on drug absorption and lymphatic transport is less clear.



“

liposomes like senolytics might be makeable with phosphatidyl choline and or as well as lecithin at $24.98 magnasonic ultrasonic cleaners on ebay. could up dose of dasatibin, rapamycin, acarbose, others. Some use 35 kHz to make liposomes, magnasonic is
42 kHz

There is something called phosol Some phosol might be 25-75% phosphatidyl choline, with MCT (like coconut oil), sunflower oil, safflower oil, propylene glycol. Mayo clinic fisetin study was “For oral administration of fisetin, mice (“At 85-weeks of
age (>20 mth), male and female mice were administered a diet containing 500 ppm (500 mg/kg) fisetin[fisetine mice live to 125 weeks, non-fisetin live 105-110 weeks without fisetin) were dosed with 100 mg/kg of fisetin in 60% Phosal 50 PG:30% PEG400:10%
ethanol” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/ at humans that is 100 mg *70, or 7 grams per dose, or using the mouse compensation number, 583 mg per human dose.

Also as to length of treatment, the Mayo clinic dose is two consecutive days, but this paper has mice going from 6 to 14 weeks, with two two week doses during that time (6-8 weeks and 12-14 weeks) and greater than halving their messed up cytes from the
two groups of two weeks of treatment during that that 8 week interval; https://www.ebiomedicine.com/article/S2352-3964(18)30373-6/fulltext The mice get 500 mg/Kg, 35G/24 hours or with mouse compensation number 2.91 g/24 hours, so at a human for 2 weeks
that would be 14*2.91 or about 41 grams, or 82 grams for the two 2 week dosage events. A different procedure at the same paper has 100mg/Kg for five days reducing markers of nonoptimality going to 1/3 of 1/5 of the untreated mice and having values
similar to those of young mice. With mouse compensation this goes from 7g a day for 5 days to 583.3 mg/24 hours for five days



I think phosphol was used at the Mayo clinic 1.4 G per day, 2 day with 10% ethanol. so ultrasonic liposomes with 75% phosphatidyl cholone and 5% ehtothol or 10% ehtanol might work. Make different versions of liposomes and then use microscope at the
marine life center to verify they actually are liposomes.

This describes making liposomes with ultrasonics: https://www.quantumbalancing.com/liposomalC.htm

At ascorbic acid it says it goes from 19% absorbed to 93% absorbed with the liposomal effect.

Weird new fruit: An apple with lots of layers of skin at its interior, or a grape with many layers of skin: I perceive I have seen vegetable or fruits with interior versions of the same fruit in them. Apple polyphenols cause 10-12% greater longevity in
c elegans and drosophila, and 43% reduction in human mortality at a correlation study, so a delicious fruit that was like 14 layers of outside skin could be a one fruit (like an apple) that has 14 times the longevity and wellness benefit from fruit
polyphenols (like an apple); One way to make this taste more optimal is to increase the sweetness, wikipedia mentions a beneficial polyphenol, “ingested phlorizin is converted into phloretin” as well as “Phlorizin is a white to yellow crystalline
solid with a melting point of 106–109 °C. It is of sweet taste”, so just breeding fruit (like apples) to have more phlorizin could make them taste better as well as possibly heighten wellness, although the benefits from eating apples. as published,
are much less than those from concentrated apple phytochemicals. Still, 14-40 times more skin at polyphenol containing fruits from nesting layers from new bred varieties could have concentrate like effects from one fruit.

Also, with genetic engineering the apples could make sweetness peptides at the skin and cortex making it more delicious than regular fruits (like apples) “Treatment with apple polyphenols extended the life span of natural C. elegans by 12%.1 As with
the previous experiment with apple polyphenols, activation of sirtuins’ calorie restriction-mimicking effects was evident.”, “apple polyphenols have been shown to extend by 10% the life span of the fruit fly, D. melanogaster, another commonly-used
model of human biological processes and aging”, also “those who consumed the largest amounts of flavonoids (found in apples and other fruits) were shown in one study to have up to a 31% reduction in total mortality.9, 10 When intake of apples
specifically was examined, that study showed as much as a 43% reduction in death from heart attacks specifically.”, “Animals fed apple polyphenols had up to a 17% reduction in the size of atherosclerotic lesions found in their arteries” https://www.
lifeextension.com/magazine/2012/4/Apple-Polyphenols-Longevity/Page-01

Phlorizin reduces some glucose things “phloridzin inhibits glucose uptake by 52%” functioning sort of like metformin or acarbose, it causes mice and humans to be skinnier, and is cardiobeneficial

Apple polyphenols are available at ebay, $17.17 22.5 grams as 125 mg and 180 pak pills. one research dose, “adults were given 600 mg/day of apple polyphenols”

Making dimers with electric plasma, “Nonthermal dielectric barrier discharge (DBD) plasma-induced structural changes in dihydrochalcone phloridzin (1) resulted in the isolation of three new methylene-bridged dihydrochalcone dimers” So, does this
work on a bunch of other polyphenols and glucosides (things with a glucose moiety) So perhaps plasma dimerized fisetin might be as or more effective than fisetin.

Million or hundred million sample mass screening of libraries of chemicals for longevity drugs: screen libraries of possible sources of new longevity drugs with libraries of chemicals from wild fungi, blenderized bugs that have been given cancer with
radiation, other blenderized inertebrates, blenderized plant tumors and galls, filtered material from ocean water and freshwater; use the published million capillary tube microfluidic sample tester I read about and possibly the yeast enumerating
cytoenumerator I read about that images 100,000 yeast per second of 6 million yeast per minute, 360 million yeast an hour.

To find the longest lived yeast, genetically engineer yeast to make more cumulative GFP (green fluorescent protein) or BFP (blue fluorescent protein) the longer the yeast live, then yeast that go through the imager and have the brightest fluorescence are
the longest lived.

A microfluidic million yeast array, that has living colonies, part of which are sampled or characterized automatically for longevity, from utilizing fluorescence imaging, and have the rest of the yeast available and alive for culturing as well as array
location findability to find the chemical that makes the yeast live longer are produced at a 1000 times 1000 grid, made from things like integrated circuit technology, laser ruling of a yeast nutrient gel, or microfluidic system fabrication technologies
like that used to produce the million capillary array.

microfluidics or just floating a layer of material atop the array grid places things from the library being screened onto the gel; Lasers then energetically comminute half or a third of the array location’s unique library material. I have seen
holographic diffraction gratings for lasers where something like a .5 mm beam is divided into many hundreds of bright dots at a patttern. With a more powerful laser, and a custom holographic diffraction grating filter, several hundred or even thousand
little point beamlets can be produced. then with a powerful enough laser these beamlets are strong enough to pop open a plant tissue fragment, some fungal cytes, (sort of like laser disintegrating a surface), popping open a library fungi blob, or
comminute just part, like a third of a marine filtrate organism. This is all done at the surface material lying on the nutrient gel, or just possibly the laser comminutes and pops a third of a library item just a few micrometers under the nutrient gel
surface. The laser could also warm the array spot with the blob it has just comminuted 1/3 of, to get the chemicals in the comminated material to diffuse rapidly through the gel, so that when yeast grow on it’s surface the yeast will be affected by
the diffusion of the chemicals from the popped cytes of the library. One benefit of a using a laser, raster scanned, or holographically microbeamed to pop library samples is that after the yeast colonies coating the upper side of the gel react to the
comminuted diffusive material with greater longevity, a 2/3 remaining sample of the original library material can be scooped up to provide a sample of the organism or part of it, that causes the longevity effect. If you are screening a library of fungi,
and the array item has a 70 times 70 micrometer bunch of hyphae under a micrometer of gel, and the laser comminutes and warm-diffuses a 20 times 20 micrometer area of the hyphae, if those fungal chemicals cause greater longevity then there is enough
remaining hyphae to find out what, and which chemicals, caused the increased longevity at that array element location. Similarly for 90 times 90 plant tumor fragments with 20 times 20 areas of laser comminution and warmth based diffusion.

Along with lasers, zapping some of a sample and leaving enough to identifity what it is, when as a library item it causes greater longevity; other methods like freeze fracturing as well as autolysis of library tissues are other methods of modifying
things at the library, on the array, to release their chemicals for the yeast to respond to as they grow.

Freeze fracturing or inducing autolysis (“The general method for making yeast extract for food products such as Vegemite and Marmite on a commercial scale is to add salt to a suspension of yeast, making the solution hypertonic, which leads to the cells'
shrivelling up. This triggers autolysis, wherein the yeast's digestive enzymes break their own proteins down into simpler compounds, a process of self-destruction.”) notably where the autolysis chemical is harmless to yeast, possibly isotonic with
dilution or addition of a buffer, produces items to be in the screened library (like the many organism ocean or feshwater filtrate, sonicated, possibly autolysed bug or plant, or fungi goop) produces availablized chemicals, notably cytoplasmic chemicals,
that are then microfluidically moved or pumped onto the yeast nutrient gel array to make a diffusive gel layer, then a rinse of live yeast on that layer to grow colonies. A flourescent laser and camera (possibly raster scans or better) looks at the
million colony array and finds the array items with the brightest GFP, then those chemicals that caused the greater longevity are looked up (the array has a numbered row column reticle), and those are items from the library that are things that can be
genetically engineered into other organisms to make sufficient amounts to medicate c elegans and mice for further longevity studies.

There are different, I think better ways of mass screening libraries of longevity chemicals at my paper notes which are likely to be imaged and on this website.

Finding new variations on longevity chemicals and drugs with greater effectiveness: have microfluidics deliver the drug to a microreactor such as a microfluidic binomat, with 11 different sequential reactions based on catalytic, enzymatic, or reagent
binomat pegs, and 100 to 10,000 base collector channels, resulting in 11 factorial different reactions the initial chemical experiences, producing 399 million different chemical variants. The microfluidics transport these to million location yeast arrays.
So you put acarbose or rapamycin among many possible drugs or chemicals, as well as those from screened libraries in the top of the binomat, and have it react, or be catalyzed 1 to 11 times sequentially altogether with things like Co, lithium aluminum
hydrate, trypsin, iodine metal, pepsin, hydroxylase, hydrogenase, cycle-opening (<=> —> \/\//) as well as others; notably if highly affordable reactants and catalysts are used at the binomat then the chemical production of those drug variants amongst
the 399 million are particularly affordable to make and the chemical engineering could favor simpler scale-up and possibly STP reactions, resulting in less manufacturing cost. I have seen an image of a fluidic binomat online; also it is possible to use
two or three binomats with 3 or 4 reactive, catalytic or enzymatic pegs each then feed the result of one binomat into another to make the 399 million variant 11 catalytic, enzyme, as well as reagent pegs. If the published 360 million yeast optically
screened per hour technology is up to it then 3 billion chemical variants can be screened in 10 hours, at the billion item array of colonies, Also possible is the laser raster scan and camera to look for the most fluorescent yeast among one billion array
items at planar array. At 6 micrometers diameter per yeast, then an array 31623 locations on a side is just 32 millimeters on a side where each array item contains 100 yeast per colony. A larger 1000 yeast per colony at the array is 197 millimeters on
a side, which goes well with 200 mm integrated circuit wafer technology.

Wikipedia says 1500 varieties of yeast have been given species names. Screening a library of yeast could find yeast that naturally live 10 times longer or more than Saccharomyces cerevisiae, the genome of those yeast could be investigated to find out if
there are proteins or other chemicals at those longer lived yeast that function as longevity drugs as well as find genetic sequences at the yeast that make mice live longer.

A liquid fungal growth medium could be poured repeatedly on soil at perhaps 14 different global locations, the soil dug up, then the soil samples mixed with 40 times volume of growth medium, then then the multiple new fungi containing culture medium
could be used at a library screening array, likely without isolation of particular species. If it is possible to give fungi cancer with radiation then screening a million or a billion of the chemicals the yeast produce while treating cancer could
produce new longevity chemicals (noting senolytics) as well as new anticancer drugs.

New antibiotics and anticancer drugs: The 11 factorial binomat as well as the most fluorescent live longest, which also goes with the dead ones being least fluorescent could also be used to find new antibiotics and anticancer drugs. If rather than yeast,
infectious bacteria were grown at a gel medium at a million or billion location array, then binomats or freeze fractured or autolysed screenable libraries could find or make those chemicals and proteins that variously kill bacteria, oncocytes at human
tissue culture, or cause them to cease bacterial cytodivision. Another variation on this is that the million or billion item array could be microfluidically exposed to carcinogens to cause 1-10% cancer at human tissue culture cytes at the array, then
amongst that 10 to 100 million oncocytes that occur at locatable array locations, compare those locations at a different array, where an anticancer library is screened. That screens 10-100 million possible anticancer and well as cancer preventative
chemicals; this is more efficient if the first array is only as large as the number of published carcinogens (10,000?) and then these carcinogens, possibly multiplexed, are placed at all the locations of the million or billion item array which then
screens a million or a billion different possible oncotherapeutic drugs and anti cancer drugs and even new cancer preventing drugs.

Screening a library of human tissues: Human tissues, particularly those at well supercentenarians, 80 year old cadavers, kindergarten age children, and teenagers could be autolyzed or freeze fractured, or possibly (although I think there are better
things than electrophoresis) electrophoresisized then differentially described and the unique per-age (children, teens, supercentenarians) chemicals quantized with electrophoresis or some other technique, to find out which electrophoresis protein bands
were absent in children that were in cadavers, and those protein bands that were in cadavers that were absent from supercentenarians. This would provide a library, the entirity of all the diferential chemical bands from electrophoresis, of possible
longevity and youthfulness heightening proteins to screen as a library. There is also the possibility to find out which chemicals and proteins to minimize: chemicals unique to 80 year old cadavers’ tissues and blood, that, if immunized against, could
cause greater longevity, as they are what the children and supercentenarians do not have circulating or have being produced.

The idea is to use actual human tissue as a screenable chemical and protein and ion library to find and identify longevity and wellness chemicals using a million or billion item array to see the effect of those endogenous human chemicals. One benefit of
screening human tissues and blood, as a library, is that the chemicals and peptides and proteins found have direct applicability and drug utility to human longevity, wellness, and healthspan.

Finding the optimal cadavers to compare the supercentenarians and kindergarteners with: it is possible there is already published research on what otherwise well 20th century persons biochemistry and blood chemistry anomalies were during the year before
those 20th century AD persons without cardiovascular disease or cancer died? That noncardiovascular disease, noncancer biochemistry that preceded death by 12 months during the 20th century may be known, or if not, can be figured out. …Perhaps persons
that died from pneumonia, flu, kidney illness, accidents and respiratory illness;

“Chronic lower respiratory diseases: 149,205”

At my paper or computer notes, I think are a bunch of repiratory technologies like lung probiotics (possibly including harmlessized beneficial proteus that migrates and produces beneficial peptide or protein drugs), a new one: enzyme-limited dose asthma
and other medications, no matter how much you inhale the dose remains the same as it is caused by (turned into functional drug with) enzymes or as a hydrated drug possibly from the thickness of mucous coating, or a new one, senolytics that can be inhaled,
perhaps at age 40, 50, 60, 70, 80, 90, 100, 110, 120, 130 and up. liposomal antivirals might be of benefit as well.


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