• Photoactivatable Gene Therapy

    From Lina Dash@21:1/5 to All on Sun Jul 16 08:36:04 2023
    One area of transcription activation useable at gene therapy and new genes at eugenics that is published is photoactivateable histone deacetylase (HDAC) inhibitor, so photoactivating that HDACi would change the amount of transcription, the amount of gene
    products like proteins, and cytostructures and tissues produced, and possibly the specific genes that were transcribed.

    Also, nonvisible areas of the spectrum can be used for photoactivatable genes, gene products, drugs and chemicals, that way the human gets to omit turning bright blue, unless they feel like it.

    What is the fewest AMU photoactivatable amino acid sequence, biomolecule, or protein that can be constructed without a metal atom? Online it says there is research on intrinisically spectrally relfecting and abosrbing at the visible range oflight
    peptides. Also, it could be that just putting a lot of energy into a peptide or protein or other biomolecule at its IR-spectroscopy absorption peak could chemically actiavte that chemical. Say you illuminate some ATP with IR-spec highest absorption
    photons, it is possible the phosphates are morelikely to pop off easily.

    Possible youthification phototherapy: illumination of ATP at IR-spec absorption peak of ATP causes ATP to be hyper reactive, thus lighting up the face with ATP optimized frequency light is quantitatively measurable at enhancing skin characteristics and
    beauty, possibly causing number of ATP phosphate reactions per second to be that of a teenager. While a person sleeps nonvisible lasers could trace out areas of illumnation all over the persons body to make ATP as reactive as possible which could cause
    greater available cytoenergy to all cytoprocesses including protein synthesis. More ATP activity at the dermis may be youthifying at the dermis. The ATP amount might sustainably remain at the same amount, even with faster ATP reactivity from mass-spec
    absorption frequency illumination; I read that the amount of mitochondria decreases with chronological time at humans, so notably, a person during the 20th century AD might have had the highest amount of ATP at their cytes, energizing protein production
    and other cytoprocesses, including dermal cyte upkeep and replacement; If at a variety of relative mitochondrial amounts the ADP->ATP cycle and reaction and reaction producing chemicals are sufficiently strong and in sufficient quantity, even at older
    persons, then the more strongly reactive IR-spec illuminated ATP would simply react faster, while maintaining the same as original levels of available ATP because the ADP->ATP biochemistry can convert ADP->ATP as fast as it appears. I have not read about
    ADP build up at older tissue, so perhaps the ADP->ATP reaction is fast, and not what affects ATP amount.

    From a longevity drug perspective, it is possible that a drug, gene therapy, or eugenic germ line therapy enhancement of ADP->ATP regeneration is beneficial. Different cvariations are possible: ADP->ATP already happens faster than ADP is produced, so
    there are only trace amounts of ADP around at a cyte, or, ADP is transported to some specialized cytoarea where it gets turned into ATP the velocity of that transport process is what directs the rate of ADP->ATP synthesis, another possibility is that
    something like fewer actual mitochondria at old tissues’ cytes causes there to be less ATP at the cytoplasm to begin with, and to regenerate and diffuse throughout the sytoplasm or be actively transported around the cytoplasm and cyte. If there is
    just less ATP to be ADP->ATP regenerated then gene therapy that just produces ATP at transfected cytes, and does not use mitochondria to generate the actual availabilizable pool of ATP molecules could cause greater cytoyouthfulness, greater human
    phenotypic youthfulness, as well as greater longevity.

    A wellness and youthification drug, and longevity drug could be producible at when Adenosine, the amino acid, at a new drug form where the adenosine is linked to a membrane transport molecule or protein, could possibly increase the amount of adenosine
    triphosphate that gets made because there is more substrate adenosine at the cytoplasm to enhance with PO4 groups. One possibility is chlorophenoxy adenosine, the chlorophenoxy group gets it past membranes, then it is available adenosine at cytes; I
    perceive I read that lipophilic molecules have better trasnport past the blood brain barrier, so as those are cytomembranes that get passed, it is possible that a lipophilic variation of adensine could be an ATP heightening supplement. You might just be
    able to put a /\/\/\/\/\ alkane tail on the adenosine, possibly detachable and at the same molecular location the PO4 attaches to at ATP; it is possible an adenosine-O-/\/\/\/\/\ where an oxygen links to the alkane would still be lipophilic enough to
    pass the cytomemebrane while the oxygen linker makes it easy for the cyte to metabolize into available adenosine (and the “extra” lipophilic alkane part); another possible cytomembrane passing adenosine molecule is a branched phosphoalkane (like a
    phosphorus clover, but with methyls or ethyls instead of Os at a PO4 shape).

    At adensosine/\/\/\, I do not know how big that alkane has to be to be lipophilic, it is possible, besides an alkane, or branched very mulimethyly alkane, that a lipophilic keytone could provide enough lipophilicity to get the adenosine past the
    cytomembrane while being harmless when the ATP supplement is converted to adenosine (and thus ATP) as well as the extra molecule parts that are at the cytosol, at doses that imaginably 100 mg to grams a day of supplement. If there are any ketones that
    are good for people, then those might be beneficial moeities for the adenosine. The other thing I have perceived is that butyls are sort of harmless or beneficial, I have vague memories of circulating butryate being beneficial soperhaps the adenosine/\/\
    /\/\ could be a butyl, or a branched butyl.

    The thing to make a cytosol ATP-available amount increasing supplement with depends on if the phosphorylator reaction chemicals are replete with lots of PO4, and could use more adenosine. If alternatively, they could use more PO4, then PO4 linked to a
    membrane transport chemical, like something lipophilic, or a peptide or protein could bring PO4 to the cyte, heightening the amount of PO4 available for cycling and recycling at the ADP->ATP cytoprocess; another approach would be to increase P phosphorus
    recycling at the body, at the cyte and cytoplasm, it is possible there is some sort of phophorous export channel that a drug could downregulate, or possibly heightening the amount of, or upregulating an enzyme that turns phosphorus containing proteins
    that get recycled or other phosphorus containing stuff, so that there is more available phosphorus to make PO4 from. Another actual amount of ATP at the cytological ADP->ATP available chemical pool raising drug or supplement could be a drug that caused
    people to only pee out 1/4 to 1/2 as much phosphorus then this could be measured as to if it increased the amount of functioning ATP, or if mice meaured throughout their lives have longer healthspan and greater lifespan from having more ATP, longer, than
    other mice.

    I read 90 lbs of ADP gets turned into ATP each 24 hours, so it is possible that the thing that affects the amount of ATP available at the cyte and cytoplasm is actually the amount of adenosine, as the phosphorylation looks highly available at 90 pounds
    every 24 hours.


    Longevity genes and drugs: different cytes hve different numbers of mitochondria, do existing SNPs of well humans cause different higher amounts of mitochondria at particulr cytotypes. Imaginably leukocytes have 200 mitochondria each, but hepatocytes
    have 700. Are there naturally occuring genes or SNPs (single nucleotide polymoprhisms) that cause a leukocyte to have 700 mitochondria or a then noting that at those gene variants or SNPs, that a 60% decline of mitochondria number across the lifespan
    just moves a leukocyte to 200 from 320 mitochondria per cyte, or a hepatocyte to 700 from 1120 mitochondria, or any kind of body cyte or tissue’s mitochondria to the average of that of a gentically pre-optimized person.


    Photoactive chemotherapy is described at published literature, and lithotripsy of solid objects at the body is published. It is possible that the double slit/binomat local area bandpass energy or also chemical filter could have local tissue applications
    as well.

    I should think of a pill that cures cancer at the developing world, like a tissue localized chemotherapeutic with really minimal side effects, or a precancer senolytic like chemical that only concentrates at cytes that are precanecrous.

    Similarly, it is possible that loading up the cytoplasm with alpha-helice (or better) constructed bandpass binomats, which unless they bioconcentrate in some way automatically (they might, or could be engineerable to custom concentrate kind of like
    mitochondria or also membranes concentrate chemical colors); If the bandpass binomats do not bioconcentrate then even as diffuse molecules they might have some engineerable effect as cytoplasm thickeners, “modelling with percolation theory new
    cytoplasm chemicals” which might then also be new drugs

    If increasing or decreasing the fluidity of the cytoplasm 20-40% causes some beneficial effect then along with binomat drugs as well as drugs that have effects modellable with percolation theory, are producible. Increasing or decreasing the fluidity of
    the cytoplasm can also be accomplished with gene therapy. Looking at the wellness and lonvevity of people with differing cytoplasmic fluidity or also cyte as gel-bag stands up from viscosity morphology, and osmotic profile measurables produces data that
    can be used to find indications of use, and effects of new fluidity/viscosity/osmotics drugs.

    As a beauty drug,
    lyse a radiolabelled cyte, then put the goop outside the cytomembrane of a well dermatocyte, then find out which specific chemicals at cytoplasm are able to migrate into a cyte. It is possible some of those chemicals, which can be taken up adermatocyte
    from topical application, are easy and simple to produce. These new membrane-passing fluidity/viscosity/osmological chemicals are topically active things that cause the gel-bag perspective firmness of hydrated skin, and with the gel-bag perspective of
    cytomorphology have the same gel-bag standupness, whihc possibly causes youthful morphology like youthful skin.

    GSK, online content So, find out what at just released cytoplasm will pass the cytomembrane of a well cyte, then make a big list of those chemicals, any of theose chemicals that do something could be new drugs that easily pass the cytomembrane, also new
    molecular variants on those cytomembrane passing naturally occuring chemicals could be new drugs. Even cytochemicals without an obvious drug effect like cytoplasm thickeners (imaginably NaPCA like proteins) could be used as tissue firming, youthful
    morphology producing ingredients that are actually absorbed and utilized from topical application.

    and possibly also cause the dermatocytes to be bnearer their younger shape, that is morphology.

    The production of hyalonuric acid and collagen at dermatocytes is, I perceive, chemicals actually at the cytoplasm of dermatocytes changing stiffness, osmological things, and cytoplasms gelness, conriuting to well tissue. So cytoplasm thickeners and
    thinners measured as to their longevity and wellness effects could be beneficial new drugs. biological systems where viscosity of cytoplasm has beneficial aspects like dermis exist, so optimizing that viscosity, osmologicalness, and morphology effecting
    gel-bag function could be a new kind of beneficial drugs.

    Actin/tubulin amplifiers, possibly (deuterated actin might be a gradualized motion track, modified actin protein, possibly even a new SNP could make fast travel actin, each of the fast and gradual versions could be measured as to effect on wellness and
    longevity.

    GSK, drug localization and Math: If there is an effect with the double slit stripes being taller than the laser dot, while being narrower, there might be some kind of math or physics relation where if you measure one well, the other measurement beceomes
    less efffective (atom electron position or velocity as measurable thing), or if there is another, different photonic system where: “if it thinks it can’t go littler it can still make x and y directions different sizes, but equationally resolved to be
    ok, such that one math/physics funtional measurable, like height, is much larger than another measurable like width” That causes the technology opportunity of making a beam system where if you cannot tell how tall it is, it gets to be arbitrarily
    skinny? Just thinking if this is a known supported math or physics phenomena, where one characteristic of a thing observable at a high resolution makes the other less observable so the system observability amount remains constant (kind of reminded of
    position and velocity at atoms and electrons); the idea is that you then take one of these “high resolution at one spatial axis if you skip measuring the rest” math or physics equation relationship function effects, and then build a localization beam
    out of it, so that way as compared with a laser dot, a cofocalization, or even a venn diagram overlap, you can make a crosshairs, sort of like one double slit “|||||||||” output layered on another “=“ to produce really optimized as tiny areas to
    localize the beam effect with. So that double slit crosshairs (or similar better approach) is a way to make acoustically activateable drugs, or also photonically activateable drugs have even higher addressible spatial resolution at human tissue.

    If tissue has a Kerr effect, then electrically, or electric field (EM field) stimulated tissue could have a gradient refractive index (GRIN) lens effect, focusing light at the interior of the tissue.

    So, doing two separate double slit like beams at 90 degrees makes a crosshairs, and the overlap of the crosshairs has more photon (or acoustic wave) energy than the rest of the lines thing is an invention; then making a material with double slit
    tesseleated repeat or at a biological system or polymer: a protein-based undulating landscape, like a screen of holes, could be used to produce a “interference lines are skinnier than the illuminating laser beam diameter” effect. So a purposed 2d or
    3d landscape of crosshairs of heightened narrowness is produced. Tht is beneficial to localization of drug activity when the drug is activated with a beam or field like light or acoustics.

    like branched amino acid polymers (noting photo, physical chemistry, or acoustically driven electret, PVDF-like, overlain layers of branches, as well as, I think other things)

    can you use pulse sequence build up to

    Different than a DNA machine, think of a board with three plates on it.

    also, inevitable, a computer, three things seperately addressable at one molecule and considered at one molecule can make :AND, OR, NOT

    This might work at diodes and CCD functional aminoacids polymers (and other biopolymers)

    Thinking about the effects of a voltage doubler at a PVDF like drug molecule that either has a localization activator (like an acoustic beam some photons, or a physical chemistry thing like warmth, cool, or bending), do you get all the chemical effect
    from half the physical chemistry bending/molecule motion? Does a frequency doubling diode bridge cause the chemical system to be responsive twice as quickly or twice as often? Can you use diodes to make a frequency halving circuit to make a molecule
    responsive to higher frequencies of potential input?

    Does having a bunch of diodes at a dendritic PVDF-like polymer Among many possibilities are new kinds of sensor molecules at new drugs, like a sonic, physical chemistry-effect, photonic, electric,

    An amino acid that can double voltage; charge cascades at biopolymers or even things like polychrolorophyll to my perception cause a pile of electrons, that is a current. Heightening the voltage also has atechnological value. I do not know how a diode
    voltage doubler works, but unidirectional charge flow in a branched polypeptide or protein seems possible. Physically I am reminded of the tesla valve as well. Then there are also possibilities like a photon frequency doubling crystal could be made out
    of amino acids, or possibly other biomolecules, to cause something like photosynthesis at chlorophyll to emit higher voltage to begin with.

    Wikipedia notes how diode bridges double frequency, to double the frequency of a photon effect at something like polychrolophyll, or possibly make a diode voltage doubler, it seems possible to make a diode bridge out of amino acids, Online it says a
    diode can be made with 11 BP DNA, so with even fewer atoms at a polypeptide (11 suggests further engineerability: imagine a quatrapeptide or decapeptide that could be a diode, then 4 of them at a fequency doubling diode bridge, then arranged at a layered
    branching thing) a diode (and diode voltage doubler and diode bridge) might be constructible from amino acids alone, other biopolymers, or even something like a boron polymer.


    or possibly some other biopolymer like PVDF-like or electret polyhydroxyapatite, cellulose, or even nonorganic Boron polymers, also chitin, or proteins; amino acids have better engineering size and particularly high ease of making; a diode bridge made
    out of something like

    optical isomers might be a basis for making diode bridges out of biopolymers, carbohydrates are well known to rotate light a certain amount, or a diffrent amount, or I think not to, based on the chirality of the molecule like a sugar molecule. Although
    that is not an antireflectance coating, it is a biopolymer optical effect that might have utility


    perhaps 4 antireflection coatings on a piece of optics will actually double the frequency of the light; on absorption that would heighten the voltage of a photoelectric material like chlorophyll
    electric eels manage to heighten voltage, perhaps hundreds of times more than ionic voltage difference between electriceelcytes.

    Doubling frequency with something very simple: https://en.wikipedia.org/wiki/Diode_bridge ”With AC input, the output of a diode bridge (called a full-wave rectifier for this purpose; there is also half-wave rectification, which does not use a diode
    bridge) is polarized pulsating non-sinusoidal voltage of the same amplitude but twice the frequency of the input.” So apparently 4 one way thingies at a diamond topology can double frequency when the feeding wave has a frequency to start with.

    Things that might function as a photon or EM diode to build a diode bridge frequency doubler from: funky layers (thinking of metal as 180 degree photon EM field reemitter, then modify it to have directionality so that if something meets it head on, it
    is absent the ability, because of the funky layering, to do a 360 degree (kind of like 180 degree) reflectance reemission; My perception is that antireflection coatings (green look lenses) of a particular thickness work this way; perhaps 4
    antireflection coatings on a piece of optics will actually double the frequency of the light; on absorption that would heighten the voltage of a photoelectric material like chlorophyll or a photovoltaic.

    something like an antireflective coating that does its thing at 90 degrees might be both impressive and extra-functional at diode-bridge-like freqency doubling and photonic path making; four of 90 degree effectives at the corners looks a lot like the
    diode DC from AC maker that doubles frequency.



    .5b What is an electrical Moire? layeres broomlike trees, or volleyball-net like netting, with a charge locationality and predictability. What is the meaning when you stack them on each other to moire them (sparse moire effect; neural netowrk effect
    from sparse moire does neural netowrk things at amino-acid sized structure, which are kind of like numerically weightable, if integers as liked, layers. Reminds me of stacks of graphene

    A new chemical could exist: a piezoelectric peptide, or possibly protein. This has greater technological function as a piezoelectric peptide sequence, possibly engineered as a branching peptide (or protein), that just tends to hang out in layered,
    overlayering bunches, with a lots of moveable, releasable electric charge (possibly from, sound or motion, chemicals, light, chemocontact (put it next to metal it wigs out) (put it next to something hydrophilic or hydrophobic and it wigs out)


    two electron (or multi-photon, multi electron, or other multi-charge causers like acoustic PVDF-like effect, or even (uh-oh it’s just a battery) ion proximity, molecule effects, noting things like ATP and phosphate groups, to my perception many many
    nonionic chemical systems, like ATP, GTP, and proteins are published )

    systems like chlorophyll polymers with the right branching to channel a bunch of electrons towards a particular area or part of the polychrolophyll (or polychlorophyll-like) molecule.

    the more things like sonic energy, drug effects, or ; with science can anything in nature be found that has a multiantenna/sensor radio telescope array like effect? Building this on purpose out of protein produces a genetically engineerable basis for
    new sensors at organisms, including electrical, radio, sonic, new kinds of light, THz waves, microwaves, and other frequencies
    CCD protein arrays

    With less utility than drugs and chemicals attached to sonic antenna molecules or polymer macromolecule antennas is acoustically activatable eentsy fluid/gel/powder beads, where the outer polymer cover or possibly lipid membrane becomes hyperpermeable or
    dissolves with acoustic activity like a cofocalized beam at depth in the body, or a near-surface-of-body treatment from noncofocailized, possibly even a spread area, purposefully large area, sonic beam. That activate, whether from dissolved or permeant
    release, or from PVDF-like surface charge effects from the sonic waves at the beads’ antenna frequency. I like the PVDF-like charge effect at keratin and chitin linked to chemicals and drugs technology more.

    With localization possibly with sonic activable drugs, drugs that benefit the fetus, like gene therapy drugs, which when injected could be made to only activate at fetal tissue, which heightens and enhancing the genetics of the baby, is from localization
    is without risk, or many orders of magnitude reduced risk of nonintended effects on the mother.

    The SNPs on the genes of the production of the produced-at-a-human amino acids would have different, and thus optimizable specifiablity at the human genome. It is even possible that the different SNPs of genes humans use to make amino acids has an
    intelligence:g effect, thus some variations on amino acid production genes could heighten intelligence. A variety of SNPs at amino acid production could also be wellness healthspan genes.

    There a a variety of supplements, incresing the use of supplements at the population would have a numerically beneficial effect, so what would cause people to aquire supplements more frequently?

    curcurmin makes wound healing more rapid, curcurmin soaked bandages and band-aids could be beneficial. Topical Curcurmin after laser or other skin outer surface layer treatments could be beneficial, but it might not, either rapidity, detailed
    thoroughness perhaps achievable gradually, normal healing velocity, or with more rapid healing.

    Curcurmin could benefit beautification effects of laser skin treatments and other beauty treatments modify the skin or dermis (lasers, chemical peels, sonication, or combinations where something like a beauty peptide, at 2019 AD some were tripeptides or
    other peptides with less than 10 mino acids) or NMN, combined with a wound healer, causes a simultaneous or near simultaneous multipart effect of dermatocyte proliferation with mitochondrial improvement, greater histonation for higher fidelity protein
    and cytostucture production, or heightened cytochemical optimization like more collagen or more hyalonicuric acid at part of the cytocontents.

    engineering, chemistry, computer ic, computer fab, longevity, longevity technology, treon, treon verdery, physics, lasers, laser, emiconductor, dimension, math, IT, IL, pattern resonance, time travel, chronotechnology, circile, eric the circle, cartoon,
    healthspan, youthspan, cpi, manufacturing, fiscal, money, software, petroleum, archive at deviantart com user treonsebastia

    All technologies, ideas, and inventions of Treon Sebastian Verdery are public domain at JUly 8,2023AD and previously, as well as after that date

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