Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing calorieswithout depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same biological
https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genes
Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing calorieswithout depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same biological
https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genes
On Sunday, November 19, 2023 at 11:34:36 AM UTC-6, Fred Bloggs wrote:without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same biological
Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing calories
https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genesYour Sloman rating: "recycled propganda", -1
On Monday, November 20, 2023 at 4:34:36 AM UTC+11, Fred Bloggs wrote:without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same biological
Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing calories
calorie intake by as little as 12%" isn't exactly the kind of specific advice that could help.https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genesBut not getting enough to eat will lead to your starving to death. There's obviously a happy medium between gross obesity and lethal malnutrition. and the low and declining US life expectancies suggest that Americans don't know where it is. "Reducing
Useful dietary advice probably has to be given to individuals, and based on their individual genomes and personal histories.
Keeping your waistline below 94cm if you are a male or below 80cm if you are female avoids a whole bunch of problems, but - like all broad-brush advice - isn't the whole story.
--
Bill Sloman, Sydney
On Thursday, November 23, 2023 at 10:34:55 AM UTC-5, Anthony William Sloman wrote:without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same biological
On Monday, November 20, 2023 at 4:34:36 AM UTC+11, Fred Bloggs wrote:
Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing calories
calorie intake by as little as 12%" isn't exactly the kind of specific advice that could help.https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genes
But not getting enough to eat will lead to your starving to death. There's obviously a happy medium between gross obesity and lethal malnutrition. and the low and declining US life expectancies suggest that Americans don't know where it is. "Reducing
Useful dietary advice probably has to be given to individuals, and based on their individual genomes and personal histories.
Keeping your waistline below 94cm if you are a male or below 80cm if you are female avoids a whole bunch of problems, but - like all broad-brush advice - isn't the whole story.
It's not 'advice', it's a report of rigorous scientific research conducted by the National Institute on Aging part of the U.S. NIH.
"To figure out which human genes were impacted during calorie restriction, the scientists isolated messenger RNA (mRNA), a molecule that contains the code for proteins, from muscle samples. The team determined the protein sequence of each mRNA and usedthe information to identify which genes originated specific mRNAs. Further analysis helped the scientists establish which genes during calorie restriction were upregulated, meaning the cells made more mRNA, and which were downregulated, meaning the cells
"For the current study, scientists used thigh muscle biopsies from CALERIE participants that were collected when individuals joined the study and at one-year and two-year follow-ups."
Their goal was to analyze a 25% calorie reduction, but the cohort could only make 12%.
All the biomarkers associated strongly with good health, longevity, and slowing progression of chronic disease, were enhanced.
If none of that means anything to you then neither will the headline.
On Friday, November 24, 2023 at 3:26:34 AM UTC+11, Fred Bloggs wrote:without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same biological
On Thursday, November 23, 2023 at 10:34:55 AM UTC-5, Anthony William Sloman wrote:
On Monday, November 20, 2023 at 4:34:36 AM UTC+11, Fred Bloggs wrote:
Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing calories
Reducing calorie intake by as little as 12%" isn't exactly the kind of specific advice that could help.https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genes
But not getting enough to eat will lead to your starving to death. There's obviously a happy medium between gross obesity and lethal malnutrition. and the low and declining US life expectancies suggest that Americans don't know where it is. "
used the information to identify which genes originated specific mRNAs. Further analysis helped the scientists establish which genes during calorie restriction were upregulated, meaning the cells made more mRNA, and which were downregulated, meaning theUseful dietary advice probably has to be given to individuals, and based on their individual genomes and personal histories.
Keeping your waistline below 94cm if you are a male or below 80cm if you are female avoids a whole bunch of problems, but - like all broad-brush advice - isn't the whole story.
It's not 'advice', it's a report of rigorous scientific research conducted by the National Institute on Aging part of the U.S. NIH.It's reporting "research" of a sort. It doesn't sound remotely "rigorous" - whatever that might mean in that context.
"To figure out which human genes were impacted during calorie restriction, the scientists isolated messenger RNA (mRNA), a molecule that contains the code for proteins, from muscle samples. The team determined the protein sequence of each mRNA and
"For the current study, scientists used thigh muscle biopsies from CALERIE participants that were collected when individuals joined the study and at one-year and two-year follow-ups."
Their goal was to analyze a 25% calorie reduction, but the cohort could only make 12%.
All the biomarkers associated strongly with good health, longevity, and slowing progression of chronic disease, were enhanced.
If none of that means anything to you then neither will the headline.What it meas to me is that the cohort - whose size you haven't specified - were eating too much to start with.
The US obesity statistics mean that this wasn't unexpected. All the waffle abut gene regulation is secondary to this obvious point.
Measuring specific mRNA levels to work out if the calorie reduction was helping sounds like a pretentious and expensive over-kill, and American medicine is famous for that.
--
Bill Sloman, Sydney
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Subject: Re: Calorie restriction in humans builds strong muscle and stimulates
healthy aging genes
From: Fred Bloggs <bloggs.fredbloggs.fred@gmail.com>
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Subject: Re: Calorie restriction in humans builds strong muscle and stimulates
healthy aging genes
From: Anthony William Sloman <bill.sloman@ieee.org>
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On Thursday, November 23, 2023 at 11:46:51 AM UTC-5, Anthony William Sloman wrote:calories without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same
On Friday, November 24, 2023 at 3:26:34 AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 10:34:55 AM UTC-5, Anthony William Sloman wrote:
On Monday, November 20, 2023 at 4:34:36 AM UTC+11, Fred Bloggs wrote:
Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing
Reducing calorie intake by as little as 12%" isn't exactly the kind of specific advice that could help.https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genes
But not getting enough to eat will lead to your starving to death. There's obviously a happy medium between gross obesity and lethal malnutrition. and the low and declining US life expectancies suggest that Americans don't know where it is. "
Useful dietary advice probably has to be given to individuals, and based on their individual genomes and personal histories.
Keeping your waistline below 94cm if you are a male or below 80cm if you are female avoids a whole bunch of problems, but - like all broad-brush advice - isn't the whole story.
It's not 'advice', it's a report of rigorous scientific research conducted by the National Institute on Aging part of the U.S. NIH.
used the information to identify which genes originated specific mRNAs. Further analysis helped the scientists establish which genes during calorie restriction were upregulated, meaning the cells made more mRNA, and which were downregulated, meaning theIt's reporting "research" of a sort. It doesn't sound remotely "rigorous" - whatever that might mean in that context.
"To figure out which human genes were impacted during calorie restriction, the scientists isolated messenger RNA (mRNA), a molecule that contains the code for proteins, from muscle samples. The team determined the protein sequence of each mRNA and
those markers are either already in line with normal limits or will change very little."For the current study, scientists used thigh muscle biopsies from CALERIE participants that were collected when individuals joined the study and at one-year and two-year follow-ups."
Their goal was to analyze a 25% calorie reduction, but the cohort could only make 12%.
All the biomarkers associated strongly with good health, longevity, and slowing progression of chronic disease, were enhanced.
If none of that means anything to you then neither will the headline.
What it meas to me is that the cohort - whose size you haven't specified - were eating too much to start with.
The US obesity statistics mean that this wasn't unexpected. All the waffle abut gene regulation is secondary to this obvious point.
For obesity studies they usually require a BMI of 30 or more. Apparently you missed the point about the before and after mRNA up-/down- regulation. It should be obvious the testing would be a waste of time on normal-/-lean bodyweight individuals since
effects to waste time studying when the endpoint is a working knowledge.Measuring specific mRNA levels to work out if the calorie reduction was helping sounds like a pretentious and expensive over-kill, and American medicine is famous for that.
mRNA are the new thing these days, bolstered by machine learning and advanced laboratory techniques ( microfluidics ) to acquire understanding of the underlying molecular chemistry. Deposition of excess fat in and of itself is too complicated in its
All the uninterested short attention span individual needs to know is : if you have a fat gut, cut back on your eating, by as little as 1/8 your normal portion, if you want to avoid early termination that is.
Don't skin your knuckles dragging them on the ground too much...
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Subject: Re: Calorie restriction in humans builds strong muscle and stimulates
healthy aging genes
From: Anthony William Sloman <bill.sloman@ieee.org>
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On Friday, November 24, 2023 at 4:28:04 AM UTC+11, Fred Bloggs wrote:calories without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same
On Thursday, November 23, 2023 at 11:46:51 AM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 3:26:34 AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 10:34:55 AM UTC-5, Anthony William Sloman wrote:
On Monday, November 20, 2023 at 4:34:36 AM UTC+11, Fred Bloggs wrote:
Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing
Reducing calorie intake by as little as 12%" isn't exactly the kind of specific advice that could help.https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genes
But not getting enough to eat will lead to your starving to death. There's obviously a happy medium between gross obesity and lethal malnutrition. and the low and declining US life expectancies suggest that Americans don't know where it is. "
and used the information to identify which genes originated specific mRNAs. Further analysis helped the scientists establish which genes during calorie restriction were upregulated, meaning the cells made more mRNA, and which were downregulated, meaningUseful dietary advice probably has to be given to individuals, and based on their individual genomes and personal histories.
Keeping your waistline below 94cm if you are a male or below 80cm if you are female avoids a whole bunch of problems, but - like all broad-brush advice - isn't the whole story.
That's what the authors want the audience to think.It's not 'advice', it's a report of rigorous scientific research conducted by the National Institute on Aging part of the U.S. NIH.
It's reporting "research" of a sort. It doesn't sound remotely "rigorous" - whatever that might mean in that context.
"To figure out which human genes were impacted during calorie restriction, the scientists isolated messenger RNA (mRNA), a molecule that contains the code for proteins, from muscle samples. The team determined the protein sequence of each mRNA
since those markers are either already in line with normal limits or will change very little."For the current study, scientists used thigh muscle biopsies from CALERIE participants that were collected when individuals joined the study and at one-year and two-year follow-ups."
Their goal was to analyze a 25% calorie reduction, but the cohort could only make 12%.
All the biomarkers associated strongly with good health, longevity, and slowing progression of chronic disease, were enhanced.
If none of that means anything to you then neither will the headline.
What it meas to me is that the cohort - whose size you haven't specified - were eating too much to start with.
The US obesity statistics mean that this wasn't unexpected. All the waffle abut gene regulation is secondary to this obvious point.
For obesity studies they usually require a BMI of 30 or more. Apparently you missed the point about the before and after mRNA up-/down- regulation. It should be obvious the testing would be a waste of time on normal-/-lean bodyweight individuals
effects to waste time studying when the endpoint is a working knowledge.Measuring specific mRNA levels to work out if the calorie reduction was helping sounds like a pretentious and expensive over-kill, and American medicine is famous for that.
mRNA are the new thing these days, bolstered by machine learning and advanced laboratory techniques ( microfluidics ) to acquire understanding of the underlying molecular chemistry. Deposition of excess fat in and of itself is too complicated in its
The endpoint was making the paper sound impressive, so that other dimbos would cite it, as you have done here.
All the uninterested short attention span individual needs to know is : if you have a fat gut, cut back on your eating, by as little as 1/8 your normal portion, if you want to avoid early termination that is.That's standard advice. We know that very few people can actually cut back their eating for long enough to reduce their fat gut and keep it reduced, so it's not useful advice. Some new and fairly expensive prescription medicines do work.
https://www.healthline.com/nutrition/weight-loss-medication#Pros-and-cons-of-weight-loss-medications
Don't skin your knuckles dragging them on the ground too much...You do seem to be projecting you own problems again.
--
Bill Sloman, Sydney
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Subject: Re: Calorie restriction in humans builds strong muscle and stimulates
healthy aging genes
From: Fred Bloggs <bloggs.fredbloggs.fred@gmail.com>
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Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing calorieswithout depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same biological
https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genes
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healthy aging genes
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On Thursday, November 23, 2023 at 11:45:09 PM UTC-5, Anthony William Sloman wrote:calories without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same
On Friday, November 24, 2023 at 4:28:04 AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 11:46:51 AM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 3:26:34 AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 10:34:55 AM UTC-5, Anthony William Sloman wrote:
On Monday, November 20, 2023 at 4:34:36 AM UTC+11, Fred Bloggs wrote:
Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing
Reducing calorie intake by as little as 12%" isn't exactly the kind of specific advice that could help.https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genes
But not getting enough to eat will lead to your starving to death. There's obviously a happy medium between gross obesity and lethal malnutrition. and the low and declining US life expectancies suggest that Americans don't know where it is. "
and used the information to identify which genes originated specific mRNAs. Further analysis helped the scientists establish which genes during calorie restriction were upregulated, meaning the cells made more mRNA, and which were downregulated, meaningUseful dietary advice probably has to be given to individuals, and based on their individual genomes and personal histories.
Keeping your waistline below 94cm if you are a male or below 80cm if you are female avoids a whole bunch of problems, but - like all broad-brush advice - isn't the whole story.
That's what the authors want the audience to think.It's not 'advice', it's a report of rigorous scientific research conducted by the National Institute on Aging part of the U.S. NIH.
It's reporting "research" of a sort. It doesn't sound remotely "rigorous" - whatever that might mean in that context.
"To figure out which human genes were impacted during calorie restriction, the scientists isolated messenger RNA (mRNA), a molecule that contains the code for proteins, from muscle samples. The team determined the protein sequence of each mRNA
since those markers are either already in line with normal limits or will change very little."For the current study, scientists used thigh muscle biopsies from CALERIE participants that were collected when individuals joined the study and at one-year and two-year follow-ups."
Their goal was to analyze a 25% calorie reduction, but the cohort could only make 12%.
All the biomarkers associated strongly with good health, longevity, and slowing progression of chronic disease, were enhanced.
If none of that means anything to you then neither will the headline.
What it meas to me is that the cohort - whose size you haven't specified - were eating too much to start with.
The US obesity statistics mean that this wasn't unexpected. All the waffle abut gene regulation is secondary to this obvious point.
For obesity studies they usually require a BMI of 30 or more. Apparently you missed the point about the before and after mRNA up-/down- regulation. It should be obvious the testing would be a waste of time on normal-/-lean bodyweight individuals
its effects to waste time studying when the endpoint is a working knowledge.Measuring specific mRNA levels to work out if the calorie reduction was helping sounds like a pretentious and expensive over-kill, and American medicine is famous for that.
mRNA are the new thing these days, bolstered by machine learning and advanced laboratory techniques ( microfluidics ) to acquire understanding of the underlying molecular chemistry. Deposition of excess fat in and of itself is too complicated in
The endpoint was making the paper sound impressive, so that other dimbos would cite it, as you have done here.
All the uninterested short attention span individual needs to know is : if you have a fat gut, cut back on your eating, by as little as 1/8 your normal portion, if you want to avoid early termination that is.That's standard advice. We know that very few people can actually cut back their eating for long enough to reduce their fat gut and keep it reduced, so it's not useful advice. Some new and fairly expensive prescription medicines do work.
https://www.healthline.com/nutrition/weight-loss-medication#Pros-and-cons-of-weight-loss-medications
Majority of those fools are self-indulging.
Mass market 'cuisine' is not created by chefs, it's created by neuroscientists who have unlocked the secrets of fats, sugars, and salts as stimulating agents for the pleasure and reward centers of the brain.
On Sunday, November 19, 2023 at 11:34:36?AM UTC-6, Fred Bloggs wrote:without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same biological
Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing calories
https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genes
I believe I saw in this group (maybe John Larkin) the quote "hunger is your friend".
On Fri, 24 Nov 2023 08:44:37 -0800 (PST), Fred Bloggs <bloggs.fred...@gmail.com> wrote:
On Thursday, November 23, 2023 at 11:45:09?PM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 4:28:04?AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 11:46:51?AM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 3:26:34?AM UTC+11, Fred Bloggs wrote: >> > > > On Thursday, November 23, 2023 at 10:34:55?AM UTC-5, Anthony William Sloman wrote:
On Monday, November 20, 2023 at 4:34:36?AM UTC+11, Fred Bloggs wrote:
Majority of those fools are self-indulging. Mass market 'cuisine' is not created by chefs, it's created by neuroscientists who have unlocked the secrets of fats, sugars, and salts as stimulating agents for the pleasure and reward centers of the brain.
Actually, most junk food (and some very good food) is developed by trial and error in professional test kitchens. Some rent for $400 per hour.
They do use some basic ingredients developed by food chemists, but most supermarket foods are made of mostly-natural ingredients, stuff that we evolved to like.
The real tradeoff is taste vs cost. Kraft doesn't use a lot of butter or saffron.
On Thursday, November 23, 2023 at 11:45:09?PM UTC-5, Anthony William Sloman wrote:calories without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same
On Friday, November 24, 2023 at 4:28:04?AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 11:46:51?AM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 3:26:34?AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 10:34:55?AM UTC-5, Anthony William Sloman wrote:
On Monday, November 20, 2023 at 4:34:36?AM UTC+11, Fred Bloggs wrote:
Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing
Reducing calorie intake by as little as 12%" isn't exactly the kind of specific advice that could help.
https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genes
But not getting enough to eat will lead to your starving to death. There's obviously a happy medium between gross obesity and lethal malnutrition. and the low and declining US life expectancies suggest that Americans don't know where it is. "
and used the information to identify which genes originated specific mRNAs. Further analysis helped the scientists establish which genes during calorie restriction were upregulated, meaning the cells made more mRNA, and which were downregulated, meaningThat's what the authors want the audience to think.
Useful dietary advice probably has to be given to individuals, and based on their individual genomes and personal histories.
Keeping your waistline below 94cm if you are a male or below 80cm if you are female avoids a whole bunch of problems, but - like all broad-brush advice - isn't the whole story.
It's not 'advice', it's a report of rigorous scientific research conducted by the National Institute on Aging part of the U.S. NIH.
It's reporting "research" of a sort. It doesn't sound remotely "rigorous" - whatever that might mean in that context.
"To figure out which human genes were impacted during calorie restriction, the scientists isolated messenger RNA (mRNA), a molecule that contains the code for proteins, from muscle samples. The team determined the protein sequence of each mRNA
since those markers are either already in line with normal limits or will change very little.What it meas to me is that the cohort - whose size you haven't specified - were eating too much to start with.
"For the current study, scientists used thigh muscle biopsies from CALERIE participants that were collected when individuals joined the study and at one-year and two-year follow-ups."
Their goal was to analyze a 25% calorie reduction, but the cohort could only make 12%.
All the biomarkers associated strongly with good health, longevity, and slowing progression of chronic disease, were enhanced.
If none of that means anything to you then neither will the headline. >> > >
The US obesity statistics mean that this wasn't unexpected. All the waffle abut gene regulation is secondary to this obvious point.
For obesity studies they usually require a BMI of 30 or more. Apparently you missed the point about the before and after mRNA up-/down- regulation. It should be obvious the testing would be a waste of time on normal-/-lean bodyweight individuals
effects to waste time studying when the endpoint is a working knowledge.
Measuring specific mRNA levels to work out if the calorie reduction was helping sounds like a pretentious and expensive over-kill, and American medicine is famous for that.
mRNA are the new thing these days, bolstered by machine learning and advanced laboratory techniques ( microfluidics ) to acquire understanding of the underlying molecular chemistry. Deposition of excess fat in and of itself is too complicated in its
The endpoint was making the paper sound impressive, so that other dimbos would cite it, as you have done here.
All the uninterested short attention span individual needs to know is : if you have a fat gut, cut back on your eating, by as little as 1/8 your normal portion, if you want to avoid early termination that is.That's standard advice. We know that very few people can actually cut back their eating for long enough to reduce their fat gut and keep it reduced, so it's not useful advice. Some new and fairly expensive prescription medicines do work.
https://www.healthline.com/nutrition/weight-loss-medication#Pros-and-cons-of-weight-loss-medications
Majority of those fools are self-indulging. Mass market 'cuisine' is not created by chefs, it's created by neuroscientists who have unlocked the secrets of fats, sugars, and salts as stimulating agents for the pleasure and reward centers of the brain.
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Subject: Re: Calorie restriction in humans builds strong muscle and stimulates
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From: Anthony William Sloman <bill.sloman@ieee.org>
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Subject: Re: Calorie restriction in humans builds strong muscle and stimulates healthy aging genes
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On Sunday, November 19, 2023 at 11:34:36 AM UTC-6, Fred Bloggs wrote:without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same biological
Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing calories
https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genesI believe I saw in this group (maybe John Larkin) the quote "hunger is your friend".
On Fri, 24 Nov 2023 08:44:37 -0800 (PST), Fred Bloggs <bloggs.fred...@gmail.com> wrote:calories without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same
On Thursday, November 23, 2023 at 11:45:09?PM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 4:28:04?AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 11:46:51?AM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 3:26:34?AM UTC+11, Fred Bloggs wrote: >> > > > On Thursday, November 23, 2023 at 10:34:55?AM UTC-5, Anthony William Sloman wrote:
On Monday, November 20, 2023 at 4:34:36?AM UTC+11, Fred Bloggs wrote:
Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing
Reducing calorie intake by as little as 12%" isn't exactly the kind of specific advice that could help.
https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genes
But not getting enough to eat will lead to your starving to death. There's obviously a happy medium between gross obesity and lethal malnutrition. and the low and declining US life expectancies suggest that Americans don't know where it is. "
and used the information to identify which genes originated specific mRNAs. Further analysis helped the scientists establish which genes during calorie restriction were upregulated, meaning the cells made more mRNA, and which were downregulated, meaningThat's what the authors want the audience to think.
Useful dietary advice probably has to be given to individuals, and based on their individual genomes and personal histories.
Keeping your waistline below 94cm if you are a male or below 80cm if you are female avoids a whole bunch of problems, but - like all broad-brush advice - isn't the whole story.
It's not 'advice', it's a report of rigorous scientific research conducted by the National Institute on Aging part of the U.S. NIH.
It's reporting "research" of a sort. It doesn't sound remotely "rigorous" - whatever that might mean in that context.
"To figure out which human genes were impacted during calorie restriction, the scientists isolated messenger RNA (mRNA), a molecule that contains the code for proteins, from muscle samples. The team determined the protein sequence of each mRNA
since those markers are either already in line with normal limits or will change very little.
"For the current study, scientists used thigh muscle biopsies from CALERIE participants that were collected when individuals joined the study and at one-year and two-year follow-ups."
Their goal was to analyze a 25% calorie reduction, but the cohort could only make 12%.
All the biomarkers associated strongly with good health, longevity, and slowing progression of chronic disease, were enhanced.
If none of that means anything to you then neither will the headline.
What it meas to me is that the cohort - whose size you haven't specified - were eating too much to start with.
The US obesity statistics mean that this wasn't unexpected. All the waffle abut gene regulation is secondary to this obvious point.
For obesity studies they usually require a BMI of 30 or more. Apparently you missed the point about the before and after mRNA up-/down- regulation. It should be obvious the testing would be a waste of time on normal-/-lean bodyweight individuals
its effects to waste time studying when the endpoint is a working knowledge.
Measuring specific mRNA levels to work out if the calorie reduction was helping sounds like a pretentious and expensive over-kill, and American medicine is famous for that.
mRNA are the new thing these days, bolstered by machine learning and advanced laboratory techniques ( microfluidics ) to acquire understanding of the underlying molecular chemistry. Deposition of excess fat in and of itself is too complicated in
The endpoint was making the paper sound impressive, so that other dimbos would cite it, as you have done here.
All the uninterested short attention span individual needs to know is : if you have a fat gut, cut back on your eating, by as little as 1/8 your normal portion, if you want to avoid early termination that is.That's standard advice. We know that very few people can actually cut back their eating for long enough to reduce their fat gut and keep it reduced, so it's not useful advice. Some new and fairly expensive prescription medicines do work.
https://www.healthline.com/nutrition/weight-loss-medication#Pros-and-cons-of-weight-loss-medications
Majority of those fools are self-indulging. Mass market 'cuisine' is not created by chefs, it's created by neuroscientists who have unlocked the secrets of fats, sugars, and salts as stimulating agents for the pleasure and reward centers of the brain.
Actually, most junk food (and some very good food) is developed by
trial and error in professional test kitchens. Some rent for $400 per
hour.
They do use some basic ingredients developed by food chemists, but
most supermarket foods are made of mostly-natural ingredients, stuff
that we evolved to like.
The real tradeoff is taste vs cost. Kraft doesn't use a lot of butter
or saffron.
On Saturday, November 25, 2023 at 3:44:43 AM UTC+11, Fred Bloggs wrote:calories without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same
On Thursday, November 23, 2023 at 11:45:09 PM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 4:28:04 AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 11:46:51 AM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 3:26:34 AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 10:34:55 AM UTC-5, Anthony William Sloman wrote:
On Monday, November 20, 2023 at 4:34:36 AM UTC+11, Fred Bloggs wrote:
Reducing overall calorie intake [ by as little as 12%] may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing
"Reducing calorie intake by as little as 12%" isn't exactly the kind of specific advice that could help.https://www.nia.nih.gov/news/calorie-restriction-humans-builds-strong-muscle-and-stimulates-healthy-aging-genes
But not getting enough to eat will lead to your starving to death. There's obviously a happy medium between gross obesity and lethal malnutrition. and the low and declining US life expectancies suggest that Americans don't know where it is.
mRNA and used the information to identify which genes originated specific mRNAs. Further analysis helped the scientists establish which genes during calorie restriction were upregulated, meaning the cells made more mRNA, and which were downregulated,Useful dietary advice probably has to be given to individuals, and based on their individual genomes and personal histories.
Keeping your waistline below 94cm if you are a male or below 80cm if you are female avoids a whole bunch of problems, but - like all broad-brush advice - isn't the whole story.
That's what the authors want the audience to think.It's not 'advice', it's a report of rigorous scientific research conducted by the National Institute on Aging part of the U.S. NIH.
It's reporting "research" of a sort. It doesn't sound remotely "rigorous" - whatever that might mean in that context.
"To figure out which human genes were impacted during calorie restriction, the scientists isolated messenger RNA (mRNA), a molecule that contains the code for proteins, from muscle samples. The team determined the protein sequence of each
since those markers are either already in line with normal limits or will change very little."For the current study, scientists used thigh muscle biopsies from CALERIE participants that were collected when individuals joined the study and at one-year and two-year follow-ups."
Their goal was to analyze a 25% calorie reduction, but the cohort could only make 12%.
All the biomarkers associated strongly with good health, longevity, and slowing progression of chronic disease, were enhanced.
If none of that means anything to you then neither will the headline.
What it meas to me is that the cohort - whose size you haven't specified - were eating too much to start with.
The US obesity statistics mean that this wasn't unexpected. All the waffle abut gene regulation is secondary to this obvious point.
For obesity studies they usually require a BMI of 30 or more. Apparently you missed the point about the before and after mRNA up-/down- regulation. It should be obvious the testing would be a waste of time on normal-/-lean bodyweight individuals
its effects to waste time studying when the endpoint is a working knowledge.Measuring specific mRNA levels to work out if the calorie reduction was helping sounds like a pretentious and expensive over-kill, and American medicine is famous for that.
mRNA are the new thing these days, bolstered by machine learning and advanced laboratory techniques ( microfluidics ) to acquire understanding of the underlying molecular chemistry. Deposition of excess fat in and of itself is too complicated in
The endpoint was making the paper sound impressive, so that other dimbos would cite it, as you have done here.
All the uninterested short attention span individual needs to know is : if you have a fat gut, cut back on your eating, by as little as 1/8 your normal portion, if you want to avoid early termination that is.That's standard advice. We know that very few people can actually cut back their eating for long enough to reduce their fat gut and keep it reduced, so it's not useful advice. Some new and fairly expensive prescription medicines do work.
https://www.healthline.com/nutrition/weight-loss-medication#Pros-and-cons-of-weight-loss-medications
Majority of those fools are self-indulging.They aren't fools, and the mechanisms that regulate our food intake have been evolving for millions of years, and aren't well adapted to times of abundance.
Mass market 'cuisine' is not created by chefs, it's created by neuroscientists who have unlocked the secrets of fats, sugars, and salts as stimulating agents for the pleasure and reward centers of the brain.They are not neuroscientists. They just keep track of what sell well, and modify it in ways that they hope will make it sell better, and build on what turns out to work.
It's empirical science, but the nervous system isn't only one being explored. And it is irresponsible idiocy. Making your customers obscenely fat so that they die young shrinks your market.
--
Bill Sloman, Sydney
On Sunday, November 26, 2023 at 2:15:29 AM UTC+11, John Larkin wrote:brain.
On Fri, 24 Nov 2023 08:44:37 -0800 (PST), Fred Bloggs <bloggs.fred...@gmail.com> wrote:
<snip>On Thursday, November 23, 2023 at 11:45:09?PM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 4:28:04?AM UTC+11, Fred Bloggs wrote: >> > On Thursday, November 23, 2023 at 11:46:51?AM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 3:26:34?AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 10:34:55?AM UTC-5, Anthony William Sloman wrote:
On Monday, November 20, 2023 at 4:34:36?AM UTC+11, Fred Bloggs wrote:
Majority of those fools are self-indulging. Mass market 'cuisine' is not created by chefs, it's created by neuroscientists who have unlocked the secrets of fats, sugars, and salts as stimulating agents for the pleasure and reward centers of the
lawyers to protect their income stream.Actually, most junk food (and some very good food) is developed by trial and error in professional test kitchens. Some rent for $400 per hour.Who cares how it is developed? The effect is that the stuff that is most vigorously marketed is addictive, and the customers eat more of it than is good for them.
They do use some basic ingredients developed by food chemists, but most supermarket foods are made of mostly-natural ingredients, stuff that we evolved to like.
The real tradeoff is taste vs cost. Kraft doesn't use a lot of butter or saffron.The real trade-off is in the effect on the customers. Americans are frequently over-weight to the point of being obese, and have remarkably low life expectancies for an advanced industrial country.
It doesn't limit the market enough to give the food suppliers any motivation to modify the food they sell to help their customer live longer, and the regulatory apparatus is leery of upsetting well-heeled companies who can afford to spend a lot on
--
Bill Sloman, Sydney
On Saturday, November 25, 2023 at 12:50:07 AM UTC-5, Anthony William Sloman wrote:
On Saturday, November 25, 2023 at 3:44:43 AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 11:45:09 PM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 4:28:04 AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 11:46:51 AM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 3:26:34 AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 10:34:55 AM UTC-5, Anthony William Sloman wrote:
On Monday, November 20, 2023 at 4:34:36 AM UTC+11, Fred Bloggs wrote:
https://www.healthline.com/nutrition/weight-loss-medication#Pros-and-cons-of-weight-loss-medications
You're being naïve:Majority of those fools are self-indulging.They aren't fools, and the mechanisms that regulate our food intake have been evolving for millions of years, and aren't well adapted to times of abundance.
Mass market 'cuisine' is not created by chefs, it's created by neuroscientists who have unlocked the secrets of fats, sugars, and salts as stimulating agents for the pleasure and reward centers of the brain.They are not neuroscientists. They just keep track of what sell well, and modify it in ways that they hope will make it sell better, and build on what turns out to work.
It's empirical science, but the nervous system isn't only one being explored. And it is irresponsible idiocy. Making your customers obscenely fat so that they die young shrinks your market.
https://en.wikipedia.org/wiki/Nutritional_neuroscience
The top selling mass produced food products, things like pizza, are classified as hyperpalatable, and that is by design, not the accidental creation of some piddler in a kitchen.
Get an education:
https://knowablemagazine.org/article/food-environment/2023/what-can-we-do-about-ultraprocessed-foods
On Saturday, November 25, 2023 at 10:30:16 AM UTC-5, Anthony William Sloman wrote:brain.
On Sunday, November 26, 2023 at 2:15:29 AM UTC+11, John Larkin wrote:
On Fri, 24 Nov 2023 08:44:37 -0800 (PST), Fred Bloggs <bloggs.fred...@gmail.com> wrote:
<snip>On Thursday, November 23, 2023 at 11:45:09?PM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 4:28:04?AM UTC+11, Fred Bloggs wrote: >> > On Thursday, November 23, 2023 at 11:46:51?AM UTC-5, Anthony William Sloman wrote:
On Friday, November 24, 2023 at 3:26:34?AM UTC+11, Fred Bloggs wrote:
On Thursday, November 23, 2023 at 10:34:55?AM UTC-5, Anthony William Sloman wrote:
On Monday, November 20, 2023 at 4:34:36?AM UTC+11, Fred Bloggs wrote:
Majority of those fools are self-indulging. Mass market 'cuisine' is not created by chefs, it's created by neuroscientists who have unlocked the secrets of fats, sugars, and salts as stimulating agents for the pleasure and reward centers of the
lawyers to protect their income stream.Actually, most junk food (and some very good food) is developed by trial and error in professional test kitchens. Some rent for $400 per hour.Who cares how it is developed? The effect is that the stuff that is most vigorously marketed is addictive, and the customers eat more of it than is good for them.
They do use some basic ingredients developed by food chemists, but most supermarket foods are made of mostly-natural ingredients, stuff that we evolved to like.
The real tradeoff is taste vs cost. Kraft doesn't use a lot of butter or saffron.
The real trade-off is in the effect on the customers. Americans are frequently over-weight to the point of being obese, and have remarkably low life expectancies for an advanced industrial country.
It doesn't limit the market enough to give the food suppliers any motivation to modify the food they sell to help their customer live longer, and the regulatory apparatus is leery of upsetting well-heeled companies who can afford to spend a lot on
https://www.obesity.org/
Looks like it's complicated:
https://www.obesity.org/wp-content/uploads/2020/05/TOS-Reasons-for-obesity-infographic-2015.pdf
Doesn't seem a person needs to know all that to realize they can't continue eating a whole 18" pizza for 'dessert.'
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Subject: Re: Calorie restriction in humans builds strong muscle and stimulates
healthy aging genes
From: Anthony William Sloman <bill.sloman@ieee.org>
Injection-Date: Sun, 26 Nov 2023 03:09:25 +0000
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