'The question has significant implications for scientists searching for new cancer treatments. That’s because drug discovery efforts often hinge on identifying, reproducing, and improving upon the mechanisms believed to be responsible for a compound’
s therapeutic effect.'

'These findings reveal the likely reason why microtubule poisons are effective for many patients. Importantly, they also help explain why attempts to find new chemo drugs based solely on stopping mitosis have been so disappointing, Weaver says.'

Drug discovery targeting a known molecular/ cellular process has to be more effective than trial and error experimentation on an unknown process.

https://scitechdaily.com/mind-blowing-cancer-discovery-common-chemotherapy-drugs-dont-work-like-doctors-thought/

--- SoupGate-Win32 v1.05
* Origin: fsxNet Usenet Gateway (21:1/5)

On Tuesday, October 31, 2023 at 4:02:50 AM UTC+11, Fred Bloggs wrote:

'The question has significant implications for scientists searching for new cancer treatments. That’s because drug discovery efforts often hinge on identifying, reproducing, and improving upon the mechanisms believed to be responsible for a compoundâ€

™s therapeutic effect.'

'These findings reveal the likely reason why microtubule poisons are effective for many patients. Importantly, they also help explain why attempts to find new chemo drugs based solely on stopping mitosis have been so disappointing, Weaver says.'

Drug discovery targeting a known molecular/ cellular process has to be more effective than trial and error experimentation on an unknown process.

https://scitechdaily.com/mind-blowing-cancer-discovery-common-chemotherapy-drugs-dont-work-like-doctors-thought/

That's a very interesting result. The more you know about the fine detail of what's actually going on, the better your chance of finding a way to do it better.
Science is addicted to the simplest possible explanation that works but when you look hard enough it can happen that you find the over-simplifications in the explanation that initially seemed to work well enough.

--
Bill Sloman, Sydney

--- SoupGate-Win32 v1.05
* Origin: fsxNet Usenet Gateway (21:1/5)

XPost: free.spam

The idiot Anthony William Sloman <bill.sloman@ieee.org> persisting in being an Off-topic troll...

--
Anthony William Sloman <bill.sloman@ieee.org> wrote:

X-Received: by 2002:ac8:4887:0:b0:41c:bd5b:79d4 with SMTP id i7-20020ac84887000000b0041cbd5b79d4mr195147qtq.12.1698721705287;
Mon, 30 Oct 2023 20:08:25 -0700 (PDT)
X-Received: by 2002:a05:6808:3609:b0:3b2:e15d:e560 with SMTP id
ct9-20020a056808360900b003b2e15de560mr3979609oib.9.1698721704980; Mon, 30 Oct
2023 20:08:24 -0700 (PDT)
Path: not-for-mail
Newsgroups: sci.electronics.design
Date: Mon, 30 Oct 2023 20:08:24 -0700 (PDT)
In-Reply-To: <9851d6ff-0b57-43f1-b06a-b3c00f0ed922n@googlegroups.com> Injection-Info: google-groups.googlegroups.com; posting-host=59.102.83.245; posting-account=SJ46pgoAAABuUDuHc5uDiXN30ATE-zi-
NNTP-Posting-Host: 59.102.83.245
References: <9851d6ff-0b57-43f1-b06a-b3c00f0ed922n@googlegroups.com> User-Agent: G2/1.0
MIME-Version: 1.0
Message-ID: <8ff00f53-2405-4736-bf9b-58929651bd5bn@googlegroups.com>
Subject: =?UTF-8?Q?Re=3A_=E2=80=9CMind=2DBlowing=E2=80=9D_Cancer_Discovery_=E2=80=93_Common_C?=
=?UTF-8?Q?hemotherapy_Drugs_Don=E2=80=99t_Work_Like_Doctors_Thought?= From: Anthony William Sloman <bill.sloman@ieee.org>
Injection-Date: Tue, 31 Oct 2023 03:08:25 +0000
Content-Type: text/plain; charset="UTF-8"
Content-Transfer-Encoding: quoted-printable
Bytes: 2711
Lines: 26
X-Received-Bytes: 2920

--- SoupGate-Win32 v1.05
* Origin: fsxNet Usenet Gateway (21:1/5)