Pupillometry predicts creativity; so do activities that cause similar pupillometric behavior as creative tasks cause more creativity? COuld children’s toys measure the amount of imagination pruring play to make better toys and play suggestions? (CCA;
cortana child advisor, voluntary amazon alexa echo speaking guidance of play

https://www.tandfonline.com/doi/full/10.1080/10400419.2018.1530533



Creative play is teachable, “This study investigated the effects of a pretend play intervention on 45 first and second grade children 2–8 months post-intervention. It was hypothesized that pretend play would be improved in the intervention groups and
that they would score higher than controls on measures of play, creativity, and emotional processes. Subjects were randomly assigned to an affect, imagination, or control group. The imagination group significantly increased on multiple play scores from
baseline to follow up and compared with controls, scores on frequency of positive affect expression were significantly higher. Differences on other scores were not found. Results indicate that play skills can be improved and cognitive play skills may
have a stronger impact on affective processes than anticipated.”



Female university students (n = 104) were randomly assigned to a coloring intervention or a logic-puzzle control group. Participants completed an inventory of psychological measures (depressive symptoms, stress, anxiety, flourishing, resilience,
mindfulness) and then participated in a 1-week intervention of either daily coloring or logic-puzzles. Following the intervention, participants again completed the inventory of psychological measures. Coloring participants showed significantly lower
levels of depressive symptoms and anxiety after the intervention, but control participants did not.



Increasing the well being of girls may increase their creativity, “The development of analytical abilities was predicted by visual and verbal short-term memory and self-concept, the development of creative abilities by visual short-term memory and well-
being” among 6th graders.

Physical “outward bound” programs, are to my perception, described as increasing self esteem and might increase well being. Could a computer graphic form of “outward bound” be possible?



Nifty thing zaps antibiotic resistant bacteria, “attached a cephalosporin molecule to a secondary antibiotic called ciprofloxacin.”…”When resistant bacteria encounter the combined drug they cleave the cephalosporin, setting the ciprofloxacin free
to kill the bacteria.” https://www.imperial.ac.uk/news/191213/decoy-antibiotics-could-around-bacterias-defences/

An upside version of the same mechanism: could NMN linked to another molecule visit (get more use at) known good mitochondria, then cleave to put another beneficial molecule in place? Possibly a “fission (duplicate) this mitochondria” chemical or
nucleotide? Finding the healthiest 10% of cytes at the body, with the most mitochondria, then causing them to do mitosis could cause higher quality tissue, promoting wellness and healthspan. It is possible that doing mitosis on the ones with the most
mitochondria at the tissue of 80-120 year olds could beneficially increase the mitochondria per cyte numbers.



Some probiotics could reduce risk of stroke, “Regulatory T [(RT)] cells have a beneficial inflammatory effect, protecting an individual from stroke. But gamma delta T cells produce a cytokine that causes harmful inflammation after a stroke.“



Probiotics that increase RT, or not: ”After 10-d treatment with Bifico capsules (combined bifidobacterium, lactobacillus and enterococcus)”, “a combination of Lactobacillus gasseri, Bifidobacterium bifidum, and Bifidobacterium longum”, “
Probiotics (Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2” However, “Regulatory T cells, which are anti-inflammatory cells of the immune system, increased during the study in all participants but there
were no differences between the probiotic and placebo group.”



Longevity technology:



Online https://www.longecity.org/forum/topic/94224-manipulating-mitochondrial-dynamics/ it says that NR, which is kind of like NMN, to be available has to be enzymatically divided into niacinimide and ribose to affect NAD levels. “Perfused or intact
intestine rapidly hydrolyzed NMN to nicotinamide riboside, which accumulated, but was not absorbed. It was slowly cleaved by an enzyme associated with the mucosal cells to nicotinamide, which was the major if not the only labeled compound absorbed.”
Notably Ribose is only $36/Kg at amazon, and I think nicotinamide is about $11 for 90 grams. so verifying that NR gets cleaved prior to ever reaching cytes suggests the mouse 20g human equivalent dose a day benefits from ribose with nicotinamide. One
plausible thing the person at imminst/longecity says is that nicotimide does lots of mitochondrial fission. “see my Exercise Like a Girl post. http://www.longecity.org/forum/topic/93915-exercise-like-a-girl-a-protocol/ In particular my last reference
that indicates NR must be cleaved by enzymes to be absorbed. So taking nicotinamide plus a greater than stoichiometric dose of ribose is essentially taking a predigested NR, except you won't have to wait hours for maximum effect on NAD, and more of the
nicotinamide will be converted into NR in the body with the excess of ribose.” … “For fission, my dose is 2g NAM + 5g ribose (equivalent to >4g NR)”



So with a plasma half life of 3.5 hours for nicotinamide and “70” minutes for ribose (D-ribose was rapidly absorbed (Tmax=36–44 minutes) and rapidly disappeared from plasma (within <140 minutes). Additionally, D-ribose was partially (18–37.5%)
recovered from urine) that suggests 4 times a day dosing for about a month. Ribose tastes yummy though.



I perceive NMN and NR are similar.

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