[continued from previous message]

Also, antibodies are as little as (less than) $399 or $435 gram, so dialysis with antibodies, or antibodies linked to dialysis membranes like to the interleukins, could improve wellness from glomming and removing harmful chemicals.



“nephrotic syndrome. This pronounced loss of proteins is due to an increase in glomerular permeability that allows proteins to pass into the urine instead of being retained in the blood.” reminds me of things that increase or decrease the
permeability of the blood brain barrier. Magnesium sulfate causes four times less permeability at the blood brain barrier, perhaps it could also benefit persons with “glomular permeability” and reduce the symptoms and unwellness associated with
kidney unwellness, it is likely that has already been thought of, near certainly.



galactose is really bad for people, but small amounts of it are endogenous. It is possible that immunizing against galactose could heighten wellness, healthspan, and sustain cognitive capability.

Cortisol, at wikipedia, notes that cortisone reduces immune system activity while also reducing irritation and puffiness. Noting that there might be many kinds of cortisols based on slight variations of the steroid molecule, it is possible that some
people have a wellness and disease-preventing better-homeostasis version of cortisol molecular variants circulating at their body. Sort of like how people can have a different blend of estrogenic molecules and their amounts from each other.

If that is an actual thing, then the genetics of optimal cortisol-like chemicals and chemical variants could benefit humans, that is persons, that is people. Genetics of the morphology of the adrenal glands could effect cortisone response and production,
as well as adrenaline linked psychological and behavioral effects. Is there a lively yet cortisol optimized adrenal gland genetics?

Could gene therapy on the adrenal glands optimize wound healing and immune “unrepression opposite of cortisol effects” while still providing the benefits of cortisol? Is there a 99th percentile of adrenal gland wellness which causes people to get
sick 1/3 to 1/2 as much from greater immunocompetency and faster healing velocity from less cortisol (note I think wikipediaq says dentists during exams healed 40% more gradually compared with when they were on vacation from higher cortisol)?

As a drug: type and dosage; perhaps deep learning AI could find the right three or four chemical “balance” to simultaneously optimize immune function and cortisol, and cortisol-like chemicals to provide the greatest wellness, “soothed tissues”,
while still maintaining immune functions that perhaps could, when optimized, cause 1/2 as much susceptibility to infectious disease progressing to actual perceived symptoms while still having “soothed tissues”. Then again, if a person gets a cold
every other year and that’s it, this is needless.

Wikipedia has a chart suggesting the 2019 range of circulating cortisol could vary up to five times, which suggests that some particular discernable amount between 5 and 25 is more optimal.

Time

Lower limit

Upper limit

Unit

09:00 am

140[49]

700[49]

nmol/L

5[50]

25[50]

μg/dL

Midnight

80[49]

350[49]

nmol/l

2.9[50]

13[50]

μg/dL



Wikipedia notes, “In dental students, wounds from punch biopsies took an average of 40% longer to heal when performed three days before an examination [from higher cortisol levels from stress] as opposed to biopsies performed on the same students
during summer vacation”

It is possible that rather than just have immunocytes at the circulation they could be part of, linked or tethered to particular tissues, that way as blood flowed past them they would glom things that benefit a human to have glommed, while omitting
traveling the whole body and potentially being immunoreactive. local tissue only gene therapy that works like Immunizations against circulating biochemicals could be beneficial.

Gene therapy could possibly cause actual tissue cytes to make actual antibody and aptamer proteins on their exterior cytomembrane, causing noncirculating yet beneficial antibody or aptamer effects. Some possibilities are GI tract cytes, myocytes and
hepatocytes making cytomembrane exterior proteins that glom longevity-nonoptimal steroids like testosterone and possibly some variants, depending on further research, of corticosteroids. Also, the amount of actual antibody activity would be related to
the generation of new cytes and the tissue and cyte and tissue renewal frequency, so antibodies that reside at the circulatory system-side of the GI tract’s cytes could have multimilligram a day antibody refresh, while antibodies that reside at the
cartilige could have a few hundred milligrams produced annually; one benefit of this is that if a medically beneficial thing happens if only 20% of a circulating biochemical is glommed and made nonactive from being removed then having the antibody at the
cytomembrane of something that renews every 90 days and is physically sized like a wrist could do the 20%, whereas comparing a bodywide circulating macrophage and lymphocyte response, that might glom 100% of some biochemical or other chemical for decades.


Possible intelligence and cognitive style gene, the BDNF (brain derived neurotrophic factor) gene, “The Val/Val variation of the BDNF gene in men and the Val/Met variation in women are associated with increased salivary cortisol in a stressful
situation.”



Longevity technology:

Royal jelly has some proteins and lipids in it and gene therapy could make these at humans, “The average survival times were 88 weeks for the control group vs. 79 weeks for the low-dose group (about 0.6 mg/kg weight), 112 weeks for the intermediate-
dose group and 110 weeks for the high-dose group, respectively, showing that RJ extended the average survival time by about 25% compared to the control group.” [27% 88:112]

A probiotic could also be engineered to make the proteins and lipids of royal jelly.

Also, royal jelly lipids could have physiological benefit and be mass producible. 10-Hydroxy-2-decenoic acid (10-HDA), the major lipid component of RJ[royal jelly]

, “10-HDA increases longevity not through ILS but through dietary restriction and TOR signaling in C. elegans.” https://www.ncbi.nlm.nih.gov/pubmed/25789174

25 uM royal jelly lipid c elegans dose;

3 times Mouse dose (126 mg/24 hours although it does not say, 3 times (3 times .6 mg/Kg) low dose might be the intermediate dose and have 25-27% mouse longevity increase; also the 126 mg every 24 hours is absent the mouse compensation number which would
reduce dose to 10.5 mg/24 hours)

The graphs show 10-30% longer lifespan for different varieties of c. elegans, although one 10-HDA genetic variant lived less long. feeding it to mammals and noting any longevity, healthspan and wellness benefits along with the 25-27% mouse study could
make this a beneficial lipid supplement, as its 10-20% longevity effects, at c elegans and 25-27% at mice are greater than omega 3 fatty acids, There is one study showing 25-27% greater lifespan at mice. if it benefits mammals It is even possible that
this would benefit people as a germline gene modification.

A different study notes that HDA reduces glucose blood level about 25% via AMPK, at 3mg/Kg or 210 mg per 70 kg human. That is about 21 grams of royal jelly at 1% HDA, or with mouse compensation factor 1.75 grams.

10 samples of “pure royal jelly” were analyzed and “Ten samples claimed to be pure royal jelly, containing 10-HDA between 0.75 and 2.54%”, also lyphilized is 1% HDA.

c elegans lives 10% longer at 10 ug/ml royal jelly, .7 grams per 70 kg person per 24 hours https://www.ncbi.nlm.nih.gov/pubmed/21858156



Also, 10 hydroxy 2 decenoic acid causes c elegans to be about 6 times better at avoiding being dead from warmth, and about 7 times as good as not being dead from poison. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350847/



A protein, and gene that are the mammalian functional-similars to royal jelly at mammals, royal jelly at mammals makes stem cells keep their flexibility (pluripotency): “NHLRC3 [the mammal equivalent of royalactin] appears to be a mammalian
pluripotency maintenance factor”,“We next wondered whether a homolog of Royalactin existed in mammals. Sensitive searches of sequence databases using iterative PSI-BLAST23, as well as aiming HHPRED sequence and structural profiles against the human
and mouse proteomes24 did not reveal any Royalactin orthologs. However, the latter computational tool revealed that Royalactin is distantly related to an existing structure in the PDB database25, a secreted salivary gland protein (SGP) from the sand fly,
L. longipalpis (PDB ID: 3Q6K)26. We then used this structure––a six-bladed β-propeller fold with no additional domains—as an accurate template for MODELLER27, yielding a high confidence model for the Royalactin fold (Fig. 3a). The resulting
superposition of Royalactin and SGP sequences was then used to seed new and more precise HHPRED scans of the human proteome, in search of a possible structural and functional analog of the Royalactin/SGP β-propeller fold. Fitting the description of a
secreted, single domain chain, with a predicted 6-bladed β-propeller architecture, only one protein, the provisionally named NHL Repeat Containing 3 (NHLRC3), arose as a potential candidate, with striking fold similarity to the Royalactin model (Fig. 3a)
. Although no known function of NHLRC3 has been identified to date, single-cell RNA-seq analyses of early mouse embryos revealed that it is expressed starting in E4.5 embryos, and that its expression increases steadily thereafter (Supplementary Figure 3a)
. To elucidate whether it served a functional purpose in stemness maintenance in mESCs similar to that observed with Royalactin, recombinant mouse NHLRC3 was added to mESC culture in the presence of serum/–LIF (serum/–LIF + NHLRC3) as well as 0i (0i +
NHLRC3). As seen with Royalactin, NHLRC3 maintained mESCs in an undifferentiated state in both culture conditions for multiple passages (Fig. 3b, c, Supplementary Figure 3b, c), with expected changes in gene expression (Fig. 3d, e). Additionally,
injection of 0i + NHLRC3 cultured cells into mouse blastocysts generated chimeric animals with germline transmission, highlighting the robust effects of this protein in vivo (Supplementary Figure 4, Supplementary Table 1). Thus, NHLRC3 appears to be a
mammalian pluripotency maintenance factor, whose existence demonstrates a remarkable conservation of macromolecular structure and function. We renamed NHLRC3 as Regina due to its conservation of functions with those of Royalactin and the queenmaker Royal
Jelly.”

This is kind of: yuck, but do termites and ants queens have any kind of similar longevizing, sole source of nutrients like queen bees? That could be a source of new longevity chemicals.

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