Longevity drug: it is published lithocholic acid at 50 micromolar concentration makes yeast live two times longer, screen a library of lithochilic acid molecular variations, some of which are ethynylized and halogated and have cytotransport moieties to
find those at 99.99th percentile effectiveness then test them on mice, those 100 molecules could be tested on 800-1400 mice as well as human tissue culture and plants; the most hydrophobic bile acids among 6 published as heightening longevity caused the
greatest longevity increase suggesting the screened library contain bile acids modified to be 1.5, 7, 24, 60, 100 times as hydrophobic as lithochilic acid, it is perhaps possible that some locations of fluorine at a molecule heighten hydrophobicity (
teflonization), and removal of -OH hydroxyl groups heightens lipophilicity so these could also be screened; lithochilic acid heightens the maximum lifespan of yeast making it noteworthy as a human longevity drug



The lithocholic acid longevity paper says there are 58 genes effecting longevity in yeast, finding homologs of those genes at mammals, and finding a completely different, complementary, group of longevity increasing genes at mammals could provide new
gene product protein drugs as well as genetic enhancement at humans and provide a way to find a model organism, possibly more predictive than mice at the the effectiveness of longevity technologies and drugs



Monthly mice and marmosets as longevity, healthspan and wellness screening organisms: mouse producing companies, corporate research departments as well as other mouse used for experimental breeding growing, and existence monitoring facilities could
purposefully make sets of mice to be used at experiments, like lomgevity, wellness, and healthspan experiments, that differ as to age at one month each, as a batch, the effect of a longevity chemical on the oldest month would provide the earliest data
after a couple months with new data being generated monthly, 8 mice per month provides a p value of .05 for each month and a math way of combining multiple months to provide reportable data like p values could be found; marmosets are primates, and
batches of four marmosets at 3 month age intervals could provide primate longevity data at six months, mouse or marmoset age batch experiments would also provide a graph of when, as to their age, a human would most benefit from a new longevity chemical
drug or chemical, 8 mice a month at up to 48 months is 384 mice; this also makes a kind of sequential metaanylasis



They could also breed organisms with 24% less tissue at a variety of organs and test known longevity molecules on them,



At humans the genetics of tissue and organ amounts (volume/mass) could be used to predict the effectiveness of different longevity drugs as well as guide experiments on primate and other mammal models, it is possible a human genetics that favors the
function of longevity drugs as well as the effect of different sizes of organs and tissues on longevity is a technology;



Organisms with a larger number of longevity genes than those at s cerevisia like other different species of yeast could possibly be found, making longevity chemical and drug screening on yeast better, they could also genetically engineer yeast to have
all the longevity genes at all measured organisms, like humans; also it is possible putting the longevity genes of humans at the genes of mice could produce a better mouse model of human longevity



Lithocholic acid at alibaba; 50 micromolar might be kind of like 376g/mole or 376 mg per millimole or .00376 mg per micromole to make 50 micromolar solution, 70,000 gram human is then about 70 liters of water or 18 times 70 moles as fluid, 3888 moles so
a 14.6 mg dose at a human; noting it is possible the GI tract might be effective at filtering lithochilic acid it is possible a liposomal version with transport benefits would be higher function; at humans cholesterol amounts and cancer risk could be
effected



Some humans make more lithochilic acid than others and have higher cancer risk, when they omit getting cancer do they live longer



Rabbits compared with mice



Lithochilic acid or a more effective at causing greater longevity engineered into a food plant makes a globally available popular food that could be measured as to its longevity effect on marmosets, possibly at a 3 month partitioned longevity measurement
model



Longevity technology



Making immunizations function better might go with giving them high amplitude surface charge, I read that the more highly charged the molecule the more macrophages phagocytosised it, I do not know what the dendritic cytes that phagocytosize novel
antigens then tell t and b cytes about like to gulp but it is possible they also prefer highly charged molecules, or possibly molecules at a particular charge range; notably along with the possibility of just attaching a highly charged atom or moiety to
an antigen, perhaps an anti malaria antigen or an anti pneumonia antigen. is the possibility of just physically coating an antigen with a highly charged molecule coating, or possibly even more effective: find the chemical dendritic cytes most like to
gulp, like they could utilize million channel microfluics with a million (6000/load/200 loads) hplc chip separated chemicals, and radiohydrogenate them from the dissociation and swap constant of pH at tritium water then find out which of millions of
molecules or moieties dendritic cytes most liked to phagocytosize, then they could attach those to antigens



Possibly if an antigen is attached to a molecular transport channel or endocytosis causing moiety that works on dendritic cytes the dendritic cytes response to the antigen at telling t and b cytes about it still functions, if so, noting active transport
can move 1000 times more molecules into a cyte per moment than passive absorption it is possible dendritic cytes could get 1000 times more antigen activity, or vaccines might even function at 1/100th the usual amount of active ingredient, that could make
vaccines an order of magnitutude or two more effective per mg of active ingredient



It is possible 1000 to 7000 (7 simultaneous different active transport moeities) active transport utilizing vaccines could be functional without refrigeration as 10 half lives are 1/1024 effect and 1000 or 7000 times active transport could make a 7, 14,
month half life vaccine last 70, 140, or 300 days; that suggests vaccines which would have been refrigerated could just be transported with the postal utility if they arrive anywhere globally at a month of unrefrigerated transport



Lyophilized vaccines effectiveness perhaps previously not of utility if it were 1 part per 100 as strong as a refrigerated or live vaccine could function well enough with dendritic cyte transport moieties (1000 times transport) to be functional at
refrigerationless vaccine locations



Multiple transport channels moeities simultaneously on an antigen could make 7000 times greater concentration at dendritic cytes from multiple parallel simultaneous transport, it is possible that some transport channel activating moieties omit causing
immunuresponse to the moeity like possibly there are glucose, ATP, or unusual yet immunononalerting self molecules the body always avoids making immunoresponse to that might also be active tranport moieties





At vaccines with active transport through the external membrane of the immune system's dendritic cytes which cause the 1000 times greater movement to the cytoplasm than passive transport that I read about, where the dendritic cytes are also able to tell
t cytes and b cytes about the new antigen even though the antigen, although 1000 times concentrated at the dendritic cyte happens to be at the cytoplasm, and there is greater and beneficial immune response to the vaccine it is possible a bunch of
previously syringe based vaccines could become oral vaccines or nasal spray vaccines making them easier for children and adults to take

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