Do enzymes make or regenerate NMN at the body? Genes for these could have SNPs that are high wellness phenotypes, gene therapy could be a wellness drug. Although NMN only made mice live 5% longer further study might find a longevity effect, notably
from cardiowellnes and perhaps youthful liver function at removing xenobiotics and reducing cancer,

Are there naturally occuring body produced chemicals that contributed to more than half of 20th century cancers? (with the idea that xenobiotics, stress, possibly EM, sedentariness and food might have caused much of the rest) SNPs about these body
occuring carcinogenic chemicals could be anti-cancer gene variations that people could optimize with genetic engineering and gene therapy. Insulin and growth factor genetics are possibilities, as is possibly sex hormone levels and SHBG (plasma fraction
that gloms steroids); I think there are published systems approaches as well, like mRNA math distribution change with physiological challenges, epigenenetics, and mitochondrial number change.

Longevity chemical: It is my perception that some cytes have less than a dozen mitochondria, and other sites might have near 400; If you do gene therapy or modify the human genome to have mRNA for proteins that would otherwise be affected as to their
amount from having fewer mitochondria per cyte from chronological duration effects produced at those cytes (and tissues) that have upper third of mitochondrial number quantity does more of the previously diminishing protein get produced, thus benefitting
the body and causing youthful levels of protein to exist? Some proteins travel from cyte to cyte as neighbors as well as circulate at the circulatory system, the proteins that travel outside the cyte could be especially engineering effective at sharing
benefit from the gene-therapied, many-mitochondiad cytes and tissues.

Genetic engineering biochemicals to be mRNA coded or produced at the ADP makes ATP cycle, which processes 90 lbs of ADP every 24 hours looks like higher volume production.

I think the ethics and engineering of making humanly intended (mind) physical or possibly neural activation alone, actions modify genetic expression and thus phenotype support the beneficial use of this technology. Prior to 2019 AD and I think anytime,
It would have been nice and beneficial, and not that much effort if people had the ability to modify the output of their genes and voluntarily modify their phenotype from simple purposed actions. Things like skipping a day of food, drinking a gallon of
water, or recieving a two hour pleasant massage could all be adressable gene switches to turn on beneficial effects while being just slightly unusual enough to omit unintentional activation. Would you like your beautiful personally appreciated hair to
grow twice as fast? Get a two hour massage once every 6 months. Getting a massage, even massage at a specific body part to get a specific gene activating phenotypic effect is a possible way to adjust pehnotype voluntarily at the individual, without
medical, chemical, social, or fiscally-linked activity based actions. You can give yourself a massage, become more socially fluent and have more fun. It is highly valuable to have previously heightened cognitive ability at all persons, people, humans to
higher amount, I think genetically engineering persons, humans, that is people at the germline and thus phenotype to be three, four, or five times more intelligent than I am, with the persons, people, that is humans having the ability to make their
beings more intelligent from that is beneficial and more optimal.

Another possibility is a minimal amount of exercise, possibly with different muscles switching on or off different genes, like if you prefer more responsive dopamine receptors (more fun!) then walk more. This increases the amount of mitochondria, the
protein production of the cytes, and possibly the actual number of muscle cytes as well. Technologically among the things are the gene therapy or modified human genome concentrating the production of biochemicals or also proteins that can circulate, or
possibly things like neuron-localized nerve growth factors produced at muscle that then increase growth of doapmine neurons. (the thighs, but only the thighs produce a chemical, that when it circulates increases a growth factor like NGF or BDNF at just
dopamine neurons) So walking exercises the thighs, and that produces chemicals that cause the brain’s phenotype to improve to have more dopamine responsiveness and more dopamine. If you prefer less dopamine you could do sit-ups. wlaking is easier
than sit-ups, to my perception, so people with this intentionally changeable phenotype genetic form might sort of have an automatic happiness fun physiological tenedency,although just genetically engineering people and germlines to be much happier is
beneficial and I support Dave Pearce’ hedonistic Imperative.


As an early 21st century longevity technology, producing more mitochondria, whether with chemicals, gene therapy, germline modification, or exercise, might increase the production of other proteins at the cytes from simply making more mitochondria, which
makes more ATP available, at all of the proteins coded at the genome. It is imaginable that just light exercise could up cytolocalized biochemicals and circulating biochemicals 20%. During 2019 AD many people found it easy and enjoyable to actually
double the mass of some of their muscles, so that might double the amount of a preferred protein or circulating biochemical. Different genome product directors and switches than exercise are likely to be more beneficial and popular than exercise.
Drinking a gallon of water all at once, or getting a pleasurable massage once every six months is much less effort to do, and sustain, as a goal-seeking activity at consciousness than sustained exercise.

As a technology it is possible to do gene therapy on a just one body part, and then have growth of that part make more of the phenotypic chemical like a protein or other biochemical or chemical, to produce local effects (GFP output changes with tissue
use which I think is published as increasing transcription at the utilized tissue, exercising should therefore make GFP at muscle tissue increase, and instead of GFP it could be different physiologically beneficial protein or other biochemical)

Surpisingly muscle, which coalesces to multinucleus cytes and can have its number of mitochondria heighten just with use, could be a location to produce beneficial proteins with go-everywhere-activity, although other gene directors and activators are
likely to be more avidly used, like massage, skipping or eating an anomalous amount of food, or getting a massage, even massage at a specific body part to get a specific phenotypic effect.

(I may have read that 80 year olds might have only 40% of the mitochondrial numbers as 20 somethings); this affects how much energy there is to produce new proteins, how much is produced, and possibly if they are produced at all. I think I also read
that the number of mitochondria, which goes with the amount of )

I read ATP might travel on actin filaments, somehow, even though ATP is an eentsy molecule. It is plausible that tubulin also effects ATP transport. If actin or also tubulin transport of ATP is actual, then drugs or genes that modify the ability of
actin to transport ATP could be wellness drugs and possibly longevity drugs, or even treatment of illness drugs. Also as a possible wellness longevity drug or genetics is the effects on the actual location arrangement and network of the actin or also
tubulin that transports the ATP. Multilane highways or dendritic branches? Concentrated depots and paths, or partially populated walkways? There is a possibility that a computer science approach to optimizing the mathematical network form of actin or
also tubulin transport of ATP could benefit humans at the cytological level with drugs or genes that reprogram actin or also tubulin based transport to optimize human well being. I perceive I have heard about research on what actin and tubulin goes where
during meiosis and why, so perhaps some of those techniques and research could benefit the technologization of actin and tubulin engineering for wellness and longevity.

I read about some chemical in Scientific american that is sometimes described as “exercise in a pill”; exercise increases the number of mitochondria at muscles, perhaps “exercise in a pill” at the circulatory system reaches more cyte types, even
neurons and also tissue types and increases the number of mitochondria at them, increasing wellnes and possibly heightening lifespan from removing nonoptimal effects at linked dynamic systems.

Another thing that increases the number of mitochondria is branched chain amino acids, “Branched-chain amino acid (BCAA) supplementation increased mitochondrial biogenesis in skeletal muscle [4]. BCAAs are 3 of the 9 essential amino acids required for
humans.” [not made at humans though]

Genetically engineering food crops to make BCAAs could have quantitative measurable wellness effects, and just possibly from more mitochondria, beneficial longevity effects. Soybeans, wheat, legumes all contribute to protein sources during 2019 AD, and
these nd other plants could be engineered to make BCAA.

Developing a plant-based milk that tastes more delicious to the majority of humans than dairy milk would be a valuable ethical vegetarian technology. Among Europeans and Americans milk, which could be technologically improved to be better-than-dairy-milk
plant based milk, provides much protein to many people. Genetically engineering plant based milk to have BCAA, possibly BCAA optimized to generate more mitochnodria is beneficial.

Technology that enhances vegetarian milk: Are there any good tasting surfactants? that would make the little globs customizable in size for flavor adjustment (improvement).

Can you put veggie milkpowder as a thin layer through an embosser with the resolution, or higher, of a holographic decalmaker? Microfeatures at blobs eentsier than a wave of light could then be used to technologically improve the milk product as
solvated globs; Also I have read about superhydrophilic and superhydrophobic surfaces, teeny spires (hydrophobic) or angled sided spaces that look like ingots (hydrophilic), it could be that embossing vegetarian milk powder to make hydrophilic or
hydrophobic features could enhance flavor. Also there is customizing globs to physical tongue receptor size for an optimal fit. Uncomplex embossing of a powder could be ultra-fiscally favored. Ihave seen candies made of sugar that have a hologram
embossed on them, so lightwave feature size at carbohydrates is a technology that has existed since the 20th century.

.5B GSK:
I perceive that GSK may have (or may not) have links to companies like nestle; could cocoa, and possibly thus chocolate, be wavelength of light feature size embossed to enhance flavor?

Are there any naturally occuring amino acids or peptides that activate the taste receptors that activate when milk tastes good; this is completely different than MSG (monosodium glutamate) in milk, but the technology of an amino acid or eentsy peptide
that enhances the flavor of veggie milk could be possible.

school lunch veggie milk
It seems like things like vegetarian nut or soy milk could be cheaper to produce than dairy milk. I think it is possible to develop the vegetrarian milk flavor until it is preferred over diry milk among most people. It is possible that more people,
throughout their lives, would like an utilize vegetarian milks if they received them at school lunches.
It might even be possible to use vegetarian milk to cause people to be weller in different ways. If the serving size of vegetarian milk is 10 Oz, as compared with the previous 8 Oz at dairy milk at identical calories, then people might drink more fluid
at school lunch. Drinking more fluid at school lunch causes a population effect of eating fewer calories at the rest of the food. Then noting that at 2019 AD, research supported that vegetarians had less heart disease, cancer, diabetes, and weighed
less with a better BMI than the rest of the population, the school administrators could say, “there’s nothing wrong with our food, but it’s awesome students are drinking nut/soy/oat milk and eating less of the other items and more vegetable sorced
food instead” So the people at school get more ounces of milk, they are, as a population at least slightly wellness heightened, and the school district spends less on the milk. That all combines to support vegetarian milks at school lunches.

MWI, that is Many Worlds Interpretation of physics: thinking of ways to cause a larger number of MWI universes to be generated from something going right, that a person, that is a human likes: The amount of quantum states produced from a proton (protons
have their own quantum effects, among them tunneling) is, I think, larger than that of af a neutron

Note: about protons or neutrons having different numbers of quantum states, and that they each generate quantum state changes at different amount for each unit of chronological moments: I think protons have more quantum states as an area with t as a
dimension, although it could be otherwise. Thinking about the quantum effects of neutrons ( I am thinking about neutrons taht are a part of atoms): if a neutron (just one as part of an entire atom) is changing a chemical rection in a flask with the
isotope effect it may or may not be having a quantum mechanical effect at a multitrillion atoms simultaneously at chemical system that is some chemicals in some water in a flask.

That the isotope effect of one (part of an atom thus nondecaying) neutron, which should have at least some analog effect on all the actual atoms at the chemical sample if analog, functions at a distance (at an aqueous chemical system it could be nm, Cm
or Km); the analog possibility comes from what seems like an analog nature of things like circles and various math of topology that seems like they could be having an effect at a 3d chemical system; The thing is that I perceive a physicist might say, “
even though you can observe it into a circle, or a sphere, or even that the sides of the container are changing (however minutely) to produce either space or time analog-like things, it is all describeable with a quantum wave function and quantum
equation, so prior to 2019 AD observations that support quantum theory support that it is actually just a quantized system, the neutrons are not having an analog effect when one neutron produces an isotope effect on an entire flask with quadrillions of
atoms at a flask of aqueous chemicals”.

That a neutron being turned into a proton causes the number of quantum states possible, as well as generateable, per unit of chonologically measured moments, suggests that making neutrons into protons could be a technologizable way to purposefully make a
larger number of MWI universes when a sentience, like a person, that is a human likes what is going on.

When a neutron is turned into a proton, that proton often attracts an electron, (does the casimir effect preclude the possibility of naked protons staying solitary?) which then do electron and photon quantum things, numerous of which are described at
peer reviewed published material as being quantum effect actions, each quantum event with an MWI branch universe 92019 AD theory); converting a neutron to a proton then causes a much larger number of MWI branches to be generated, for the theoretical
duration of the universe. Although I am not yet educated sufficiently able to use aleph numbers to do calculations, if the universe happens to be chronologiclly nonfinite then the number of MWI universes generated from one neutron being converted to one
proton is a nonfinite number, and further, that nonfinite number has many many MWI branches (I perceive I have read that human researchers might have different scientifically supported ideas about whether MWI branches are finite or nonfinite in quantity).

Thinking about a new proton coming from a neutron: a new proton at a chronologically nonterminating universe would have a nonfinite number of MWI branches though; or perhaps could, I read about people who think cooling all atoms to their quantum ground
state is a spontaneous actual process at the universe; although MWI suggests that things like time crystals and the delayed quantum choice eraser could effect quantum-capability of atoms retrocausally or cyclically at some amount of the MWI universes; I
have heard of these things, so the MWI universe I am in might be entropically nonmonolithic

A technology that utilizes the difference between a proton and a neutron to cause more MWI branches where a human things things are pleasantly going the way they like. I like Serina, so when I send her a text, and she replies I think my life is going
well and I am particularly enthused about MWI branches arising from a universe where Serina texts me, I then press “make proton” on my phone, and the phone makes some protons out of neutrons. That generates a nonfinite (proton at nonchronologically
finite universe version) number of universes that branch from one where Serina communicates with me. I could even press on “make lots of protons” if Serina says something like, “I like you” or “let’s meet”.

AI and software developing MWI technologies: With MWI technologies it is my perception it is endless quadrillion of times better to write them immediately rather than wait a moment to write them as a vast plurality of MWI branch universes will
potentially benefit from new, accurate, actual, technology producing MWI content; that suggests that AI (artificial intelligence) writing, communicating, or doing experiments could then validate and quantify the “research on the MWI should be
accomplished immediately as it affects endless quadrillions of universes differently if you delay 1 millisecond” way of looking at the MWI. A human that builds an AI that figures out new things about the MWI, or even just develops the math and
technology space, a few trillion times faster than a thinking writing human is a thing that could be of value from the perspective of a person like me that values making happier more optimal, Dave Pearce’ headonistic imperative actualized universes. (
AI produces MWI research and technology a trillion times faster than me) During 2019 a 4Ghz processor would do 4 billion computations a second, and 250 seconds would be a trillion computations, so an AI doing a few trillion more MWI research things and
technology items than I would in an hour is plausible; a few sequential instructions at a parallel 4Ghz AI compared with a few minutes of human thought.

Immunizing against a million topologies; screen antibodies to things like “a torus of alpha helices” or a “square of beta sheets”, or “something made of protein twice as wide as it is long” at human tissue culture. This edits the amount and
kind of chemicals and biochemicals shared between cytes. Then find out what these categories, and mathematically developable forms (if it kind of works on one topology, then they can find logical math extensions from that topological shape; immunizing
against alpha helix torus is 20% effective at heightening organism, like a human, that is a person’s longevity, so the math suggests: vary diameters, immunize against an “8” and an “88”, and immunize against a tetrahedron made with a torus on
each side, and others) of them to find the topological antibodies that cause human tissue culture arrays to be weller and have greater longevity; (immunize against many to mid AMU rod looking groups, curlies, heaps of alpha helices, piles of beta sheets)

Immunizing that prevents senescence could be the effect of screening topological libraries of antibodies. Notably research on senolytics apparently supports this. Senolytics terminate senescent cytes; as a result the senescent cytes cease to export
chemicals and biochemicals to their between-cyte environment as well as the circulatory system. Those senescent cyte produced chemicals caused unwellness at other previously well and non senescent cytes. Terminating the senescent cytes causes the well
cytes to have things continue to go well, and I think I read that mice that get senolytic therapy are healthier, perhaps phenotypically younger, and have longer lifespans, all from eliminating the chemicals the senescent cytes made. So, could you
immunize a lab mammal and then a human, that is a person, against the entire library of chemicals and biochemicals that the senescent cytes produce; such an immunization could have the effect of a senolytic drug as it mops up the nonoptimal chemicals.

So, supporting the screening of topological antibodies, senolytics’ effectiveness and conceptual form apparently supports the idea that there is a whole bunch of things, and that if you treat them as a group, you can get an overall bulk effect, even
though the bulk effect could contain optimal and nonoptimal chemical effects simultaneously.

Some different bulk effects at the human body that I think are published as causing benefit are things kind of like: more mitochondria causes more protein production, and more mitochondria thus produce greater wellness and youthfulness. Another bulk
effect is putting more genes, of any kind, on histones, I think (possibly) causes greater longevity and fidelity of proteins produced.

As a bulk effect, immunizing against topologies could produce beneficial effects like wellness and longevity at the entire body. The thing is to make a lot of them and screen the library to find the ones where the average and distribution of the blended
bulk effect is quantitatively and qualitatively measured as much better for the human than an absence of the topological immunization.

Going with this technology of Immunizing against extensible classifications (like topology) could be immunizing against electric charge of an entire protein. Immunize against everything with -.499 to -5.00 charge and a thousand others from +4.99 to -4.
99). this diminishes the amount of the proteins circulating, or zapping those cytes with these charges of protein at their surface; this would have a bulk effect, and then the bulk effects of a few thousand variations, or a few million variations, are
listed at a computer with the immunization that produces the greatest beneficial bulk effect at the top of the list.

Screening topological and protein molecular electronegativity: Make a human tissue culture of neuron, cardiac and other human cytes, although multiwell plates already exist, you could use IC production technology to make a 1000 times 1000 grid, which is
one million human tissue culture samples per screenable plate. The thing is that if you screen a 1000 times 1000 times physical array you have characterized the effect of more than a million different antibodies on the wellness and longevity of things
like neuron and cardiac and other tissue culture, which could be predictive of wellness and longevity effects at those tissues and also the entire organism.

Notably increasing wellness and longevity at the entire organism is the resulting beneficial drug from screening vaccines to topologies at a big array. These new wellness longevity drugs are produced when topologies and electron negativities of proteins
are found that have beneficial bulk of physiology effects.

I read that BCAA cause more mitochondria to be at cytes. A person with abilities at planning and creating food, might be able to make a new popular food based completely around BCAAs, possibly a completely new BCAA, with a different amino acid sequence
that tastes better than 2019 A.D. BCAA (Noting the mitochondrial amount going up I think I read, has higher wellness (and possibly longevity) effects.

I perceive that caffeine is a 2019 AD popular drug, notably at beverages.

So, can you attach a biguanide (metformin-like molecule) to caffeine, which alread tastes aversive, to make a longevity version of caffeine that is a stimulant that makes people live longer and have less heart disease and less cancer. Lilacs make
biguanides, tea makes caffeine, so both at one gene engineered plant could be produced. Along with the rest of the world China might go for longevity tea from a GMO crop.

If you chelate beneficial things, even like a biguanide (metformin-like effects) does the taste become much milder? EDTA seems to be mild flavor. Are there any naturally occruing plant products that are chelation agents? Then you could blenderize and
fractionate the source plant and soak the thing to be chelated in the soultion that had the naturally occuring chelator concentrated.


Although ECGC is already at tea, perhaps it could be engineered into coffee.

Curcurmin comes from a plant in the ginger family, perhaps ginger could be engineered to be good for people and make curcurmin. A mild flavored more massive Ginger root with curcurmin might replace the potato

Tea bred or engineered to have 10x as much ECGC, noting tea already produces ECGC.

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Making immunizations function better might go with giving them high amplitude surface charge, I read that the more highly charged the molecule the more macrophages phagocytosised it, I do not know what the dendritic cytes that phagocytosize novel
antigens then tell t and b cytes about like to gulp but it is possible they also prefer highly charged molecules, or possibly molecules at a particular charge range; notably along with the possibility of just attaching a highly charged atom or moiety to
an antigen, perhaps an anti malaria antigen or an anti pneumonia antigen. is the possibility of just physically coating an antigen with a highly charged molecule coating, or possibly even more effective: find the chemical dendritic cytes most like to
gulp, like they could utilize million channel microfluics with a million (6000/load/200 loads) hplc chip separated chemicals, and radiohydrogenate them from the dissociation and swap constant of pH at tritium water then find out which of millions of
molecules or moieties dendritic cytes most liked to phagocytosize, then they could attach those to antigens

Possibly if an antigen is attached to a molecular transport channel or endocytosis causing moiety that works on dendritic cytes the dendritic cytes response to the antigen at telling t and b cytes about it still functions, if so, noting active transport
can move 1000 times more molecules into a cyte per moment than passive absorption it is possible dendritic cytes could get 1000 times more antigen activity, or vaccines might even function at 1/100th the usual amount of active ingredient, that could make
vaccines an order of magnitutude or two more effective per mg of active ingredient

It is possible 1000 to 7000 (7 simultaneous different active transport moeities) active transport utilizing vaccines could be functional without refrigeration as 10 half lives are 1/1024 effect and 1000 or 7000 times active transport could make a 7, 14,
month half life vaccine last 70, 140, or 300 days; that suggests vaccines which would have been refrigerated could just be transported with the postal utility if they arrive anywhere globally at a month of unrefrigerated transport

Lyophilized vaccines effectiveness perhaps previously not of utility if it were 1 part per 100 as strong as a refrigerated or live vaccine could function well enough with dendritic cyte transport moieties (1000 times transport) to be functional at
refrigerationless vaccine locations

Multiple transport channels moeities simultaneously on an antigen could make 7000 times greater concentration at dendritic cytes from multiple parallel simultaneous transport, it is possible that some transport channel activating moieties omit causing
immunuresponse to the moeity like possibly there are glucose, ATP, or unusual yet immunononalerting self molecules the body always avoids making immunoresponse to that might also be active tranport moieties

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Making immunizations function better might go with giving them high amplitude surface charge, I read that the more highly charged the molecule the more macrophages phagocytosised it, I do not know what the dendritic cytes that phagocytosize novel
antigens then tell t and b cytes about like to gulp but it is possible they also prefer highly charged molecules, or possibly molecules at a particular charge range; notably along with the possibility of just attaching a highly charged atom or moiety to
an antigen, perhaps an anti malaria antigen or an anti pneumonia antigen. is the possibility of just physically coating an antigen with a highly charged molecule coating, or possibly even more effective: find the chemical dendritic cytes most like to
gulp, like they could utilize million channel microfluics with a million (6000/load/200 loads) hplc chip separated chemicals, and radiohydrogenate them from the dissociation and swap constant of pH at tritium water then find out which of millions of
molecules or moieties dendritic cytes most liked to phagocytosize, then they could attach those to antigens

Possibly if an antigen is attached to a molecular transport channel or endocytosis causing moiety that works on dendritic cytes the dendritic cytes response to the antigen at telling t and b cytes about it still functions, if so, noting active transport
can move 1000 times more molecules into a cyte per moment than passive absorption it is possible dendritic cytes could get 1000 times more antigen activity, or vaccines might even function at 1/100th the usual amount of active ingredient, that could make
vaccines an order of magnitutude or two more effective per mg of active ingredient

It is possible 1000 to 7000 (7 simultaneous different active transport moeities) active transport utilizing vaccines could be functional without refrigeration as 10 half lives are 1/1024 effect and 1000 or 7000 times active transport could make a 7, 14,
month half life vaccine last 70, 140, or 300 days; that suggests vaccines which would have been refrigerated could just be transported with the postal utility if they arrive anywhere globally at a month of unrefrigerated transport

Lyophilized vaccines effectiveness perhaps previously not of utility if it were 1 part per 100 as strong as a refrigerated or live vaccine could function well enough with dendritic cyte transport moieties (1000 times transport) to be functional at
refrigerationless vaccine locations

Multiple transport channels moeities simultaneously on an antigen could make 7000 times greater concentration at dendritic cytes from multiple parallel simultaneous transport, it is possible that some transport channel activating moieties omit causing
immunuresponse to the moeity like possibly there are glucose, ATP, or unusual yet immunononalerting self molecules the body always avoids making immunoresponse to that might also be active tranport moieties

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With higher IQ linked to greater longevity they could do brain scans of super centenarians and find out if their actual brain mass at each millimeter of brain structure varies from others, quantifying positron emission tomography amounts of radio
labelled chemicals the supercentenarian variation at what amount of actual neurotransmitter chemical is where as well as neurotransmitter receptor density is describable, and could be associated with longevity, and longevity chemicals active at mouse
brains, complementary to while being different than nootropics could be screened and produced; non cognitive areas of the brain could also be heightening longevity (Epithalon, a pineal peptide, is published as causing 24% greater longevity) new longevity
drugs developed to address brain areas that might be outside cognition are also beneficial

Screening stimulant molecules to find out if there are longevity heightening molecular variations:

On finding 99.9 th percentily of longevity heightening stimulants at 96 well plate fish, screen the 99.9th percentile stimulants on mice, quantify absence of emotive or also social conflict, optimally less than the amount of median unmedicated mammal
emotive and social conflict, also beneficial is quantifying mouse actions, communicating, feeling happy, play, and willingness to travel at open spaces, another the benefit of a longevity producing stimulant could be quantified conviviality, also mating
frequency,

Stimulants at less than a behavior changing dose could also cause greater longevity particularly screened as a library at yeast as well as c elegans;

At perceptible stimulants a voluntary human experimental participant verifies the longevizing stimulants as pleasant and fun then marmosets at age batches verify longevity effect while having fun

It is beneficial to
Screen longevity stimulants as beneficial or neutral to the fetus, or are also absent passing the placenta

Rapamycin is published as causing 60% greater longevity as well as higher cognitive performance at 126 ppm at mice, I took some at kind of near 24-63 ppm and noticed it made me kind of excited so I did not go to sleep, so I started taking it, when
possible, before or near noon, it is possible that screening a library of rapamycin molecule variations to find nootropic or also beneficial prosocial stimulant versions could be even more longevizing than rapamycin (60% rapamycin with near 20 from IQ is
80 pct longevity heightening) stimulant ability of rapamycin molecule variants could be screened at c elegans to see how fast they move around before quantifying the effects on longevity, social behavior and cognition at mice;
attaching a nootropic or stimulant moiety to rapamycin could put the 21% greater longevity from higher IQ with the 60% longevity heightening from rapamycin to make a drug with 80 pct greater longevity effects that could be quantified at age batched
marmosets

Epinepherine I heard, is aversive, it might be linked to heightened cognitive function as I perceive I read some humans get hyperfocused, more simultaneously aware, and mentally and physically faster possibly at a voluntary epinepherine producing
activity, screening a library of numerous epinepherine variants could find a fun, harmless, pleasant, peaceful, multiarea beneficial longevizing version

Organoids as tissue culture forms that could be utilized toscreen chemical libraries, positron emission tomography on tray stacks, 3-7 mm per well, 49 rows columns and stacks per positron emission tomography scan occurrence scans 117,000ish verified as
being absent isness organoids

Is a way to verify absence of presence of being, like at 3mm neuronal brain-like nuggets like organoids to position the thing being qualified as absent presence of being as a quantum system observer, then if the system is observationally resolved there
is possibility of presence of being, if the thing is absent quantum resolution then it is possible the object being qualified as to absence of presence of being like an organoid is either not being attentive, like a human that is so romance focused they
fantasize about their girlfriend while looking at the quantum apparatus and do not notice what is going on, or rather than nonattentive it is possibile the organoid is actually absent presence of being, while quantum resolution as compared with a 3mm
nugget of a different tissue would make it so they built different organoids that were absent quantum resolution capability

organoids with reduced likelihood of having presence might be built with a matrice of neurotransmitters, neuron types, or morphologies omitted; screening things at organoids matricized to have serotonin with acetylcholine but not dopamine at one group
of organoids, while a different group of organoids has a different neurotransmitter matrice, causes nonbeing form when screening a million organoids at chemicals like beneficial longevity drugs;

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Longevity technology

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In article <66454bdf-6c99-4f11-a249-f580c51e650dn@googlegroups.com>,
Treon Verdery <treon3verdery@gmail.com> wrote:

Longevity technology

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Subject: Longevity technology
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Spamtrollers are trolls posting useless spam thinking it is content
but are posting useless noise. Thoses trolls are as bad as Donald
Trump on Twitter.

Depeer Google groups Now!!
--
Member - Liberal International This is doctor@nk.ca Ici doctor@nk.ca
Yahweh, Queen & country!Never Satan President Republic!Beware AntiChrist rising!
Look at Psalms 14 and 53 on Atheism https://www.empire.kred/ROOTNK?t=94a1f39b Quebec oubliez les extremes et votez PLQ Beware https://mindspring.com

--- SoupGate-Win32 v1.05
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Finding completely new hormetics that increase longevity, healthspan, wellness and cognitive function

Endoplasmic reticulum hormetic is published. Could there be more, what about a golgi apparatus hormetic

Catdiocyte hormetic, screen a library of molecules at tissue culture, one possibility is that at other muscles, exercise is kind of hormetic, microtears and lactic acid build up, as well as likely other chemicals are produced, if there are like a
plurality of hormetic or hormeticish chemicals produced at smooth and regular muscle that is exercised to greatest strength build up or greatest volume build up then they could make cyto homogenates and also gather between cyte fluids endocytotically and
between cytes then test them on mice or 3g shrews, it is possible one exercised beaver or cow could provide sufficient homogenate numerous shrews of mice

Plasma protein fractions from one unwell monozygotic twin mouse or rat or pig transfused to the well one to find out if it becomes better than well, a possibility is screening plasma from mid unwellness as well as first 24 hours after recovery (absence
of fever, normal motion patterns) monozygotic twins or clones

NR mitochondrial pluralization is hormetic-like, is there a hormetic mitochondria fuel, screen a library of sugars. Galactose is really bad for mammals, could there be a molecular variant that is 1/200th as bad with longevizing, healthspan increasing,
cognition maintaining or increasing effects

Is quadrophospate hormetic (compare ATP)

A possible harmless to experience brain hormetic could be the response of the brain to longevity producing caloric restriction, among mice that rapidly regain their full, measured during ad-libitum feeding, cognitive abilities even while calories
restricted, or heighten them while calorie restricted it is possible to search for a hormetic response at the CNS, this can also be characterized outside the CNS at peripheral nerves like lever press velocity before and after caloric restriction and
after full recover while still being caloric restricted, the volume of peripheral nervous system material may not be as much, although the greater structural simplicity might focus hormesis effects on physiochemical rather than brain structure

Low dose imterleukins, or modified interleukin proteins tested st tissue culture

Digital gradient matrix lasers on dermis, from 1 mW all the way to 1 Watt, and different pulse modes and light frequencies, then if any of these are hormetic. Possibly measurable with a computer camera looking at histology images to find any regions that
have netter than well histology or the histological morphology of a person 14 years younger, then the cytoreactions from that wattage, pulse method, and frequency can be characterized to find out if cytes internal to the body having those hormetic
chemicals upregulated or drug activated causes a beneficial hormetic response without internal lasers

Cytoplasm mass fractions, like 1000 of them, perhaps from unwell cytes with 95/100 likeliness of full recovery could be screened, when I get a rash there is a continuum of responses from minutes or hours of non-oozing erythema to microcrusts, along that
continuum there are likely 95/100 fully recovering cytes, I am not aware of any rash that seems to heighten wellness on it ceasing, beauty chemical peel treatments at less than peeling doses could possibly (possibly not) be characterized as causing
histological hormetic benefit, I have doubts about systemic use, but salicylic acid makes yeast live 400% longer and I think may have been used at dermal chemical peels, so perhaps not the salicylic acid as a drug but the cytochemicals it causes to be
emitted, upregulated, or even decreased, possibly at tissue culture, if salycilic acid does have a beneficial hormetic effect they could screen a library to find molecules that have double of an order of magnitude greater hormetic effect (halogenation or
lipophilicity version combined with hydrophilic version could do it)), I perceive salycilic acid is water soluble)

Screening a library like these and othets of a few thousand possible new hormetics could find those with the greatest longevity and healthspan effects, c elegans doubled lifespan from mitochondrial uncoupling is, to my perception ascribed to a prenatally
activated lifelong hormetic response

Longevity technology

GSK salycilic acid might be hydrophilic and lipophilic things pass the blood brain barrier faster, I heard about the acetyl doing that but would propyl transport the drug even more rapidly, also decanoic acid esters are published as causing greater
longevity, perhaps a salicylic acid decanoic ester would be beneficial

Has GSK tried combining piperine at its antipyretic an analgesic pills, 2-2000 times dose multipliers are published with piperine and if two or more doses fit at one pill they could make 24 hour acetaminophen, ibuprofen, and naproxen with the same sized
pill

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An artificial telomerase gene is producible that codes the production of the least degradable proteins at telomeres, perhaps telomere proteins are charged, and perhaps neutral charge or a charge that decreases nonpurposed popping off of telomeres'
sources of being degraded proteins could be utilized to make them, they could be amino acid repeats, if they are then different amino acids could be used and tested on yeast before making them a part of the human germline, telomeres geometry could be
changed as well, perhaps a nub is more durable than a straggly line

Things that fill children with happiness
toys that both people can be right about, plentiful toys, toys dolls that sit up or stand on their own

A computer, like the computer at dollar store scientific calculators, moves masses interior to the doll such that any position you put it at it remains gravitationally stable in that position, the computer could just figure out what you preferred, or
with a photonic sensor or capacitive touch lamp like sensor could tell when you touched it on its chest to tell when it was at the right position, perhaps some dolls and toys could even ambulate using this technology

A that spread on a shaved or waxed area causes hairiness

a beauty peptide palmitate of dodecanate could administer quantified beauty peptide activity for seven or fourteen days or longer with one application, it could be contained at liposomes or other microsomes, using that beauty peptide once every 24 hours
would build up the dose as well as the single dose lasting 7 days, similarly as a treatment for a topic dermatitis and dermatitis could a 7 or 14 day active liposome or microsome administer drugs like topical corticosteroids at the dermis

Ethynyl corticosteroids, picogram active ethynyl progesterone is a steroidal molecule, could ethynyl corticosteroids make antiatopic dermatitis or antidermatitis or asthma treatments better

Does curiosity have a genetic component, if it does then people could make gene therapy to cause greater curiousity and make it part of the human germline, a nootropic with a brain localization chemical could also cause greater curiosity; based on
curiosity genes' gene products enteric protein drugs that cause curiosity could be made, I wonder what curious marine mammals like whales and dolphins would be like, this could also benefit children, even their educational activities

A white round software product and a white and blue software product could cause greater white and blue way of mind globally, linked to soft round beautiful white and blue toys children would practice white and blue ways of being and have referent forms
at their minds, gel forms that interact with the software, rounded and with greater puffiness than a gel mouse pad I have or also like balloon shapes (all rounded)
Also good elves and pixies white and green software and linked toys

Tube balloons with lenticular soft round rises, blobby things that look kind of chemical orbitals, looped balloons multitorus, tricircles, pacifier shapes, white and pastel colors

Although not a technology, unless utilized at software, narrative sequences and dialog between white, blue, and green characters form the communications, thought of and author presented options, at a book and children's book, possibly a children's book
adults like reading, as well as media scripts, at software I think I have viewed things where, optimally you write your own content, communication and speech to interact with the software characters but at software (and I think IT pattern streamlined
thought nuggets, cliches, junk food thoughts, words at the mind that say about 40% of what you actually mean, and words that happen at a person's head that make a person think or experience a thing like "who is writing my lines" should be minimized) I
have seen programs where you indicate one of a plurality of options to say, communications that are white blue and green presented as software talking, communications, activities make these part of the software users facile, practiced, and style, of
talking and communicating

Some things people write use travel to move the narrative along, it is possible a narrative constructed around building something beneficial could do this too
Elves suggest a forest, then find an interesting way to describe changing a law, that is an improvement to the previous law, to make it so what some call undeveloped land has forests on it, anybody and all people can walk the forested land permissionless
as they like without fees, the person whose land it is then is without concern, and the person whose land it is even gets revenue from a thing that says 'for the next n centuries transfer or clearing the land will be absent occurrence, a voluntary fiscal
giving box, or a few, are permitted on the land", then factoring (projecting value) provides the land haver with money up front, so they seek out the opportunity

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Software and automated microscopy could quantify the size and quantity of each organelle at each kind of cyte and tissue, and compare these to the size of organelles at a plurality of organelles at longevized mice, c elegans, and even calorically
restricted longevized primates, even voluntary calorically restricted humans, also the organelle size and quantity difference between calorically restricted mice and rapamycin longevized mice' differences could be used to find out if greater or lesser
number of organelles is numerically linked to longevity and genes, cut I differentiation chemicals, and drugs that cause different amounts and sizes of organelles are produced to quantify their effects on longevity, if there is a longevity, wellness,
cognition, healthspan and progeny beneficial effect then that is a gene therapy and germline modification technology

Is it possible to longevize bacteria so beneficial bacteria like mycorhizzial bacteria and probiotics are better, GFP that accumulates as the bacteria then flow cytometry that finds the 99.999999999th percentile of longevity at a trillion bacteria broth,
then breeding those bacteria and screening again a few times longevizes bacteria as would GFP light emission genetically engineering a million different species of bacteria, among them million year lifespan endoliths, at a mixed culture broth and using
flow cytometry to find the longest lived species then combining the longest lived species together with a nonspecific gene swapping enabling protocol, calcium ions is one of them, screening for 99.9999999999th percentile of longevity, along with the
longevization of bacteria that have human utility, the longevized bacteria could have some longevizing chemicals that benefit humans, a million bacteria at a million spacious integrated circuit technology wells, with culture medium where yeast are then
also sequentially placed, where the mass of the bacteria makes up 1/9 of the area of the wells to make up 14 times that of the volume the yeast would occupy, then the wells after a million different heightened longevity species of bacteria have grown a
mass of material at the media, are then exposed to ultrasonic acoustics to homogenize (make a homogenate from) the bacteria, and then a yeast inoculation occurs possibly from a light spray of yeast culture or microfluidics, the yeast are grown and
screened at 99.99th percentile of longevity and those chemicals quantified at c elegans and mice as to their longevity increasing effects, this is repeatable at different wafers with widely differing bacterial sources, cool weather bacteria, aerophile
bacteria, archaeobacteria, human somatic form, also GI tract bacteria, multicentury lifespan clam, tortoise, and shark bacteria, multicentury lifespan whale poo bacteria, it is pleasant that any longevity heightening chemicals produced that longevize
mammals and humans, that is people, are also mass producible at bacteria

Longevity beauty peptide combined
It is possible that putting a cytomembrane transport moiety

Sensationless, scentless piperine molecular variant, which could be halogenated, ethynylized, as well as acetylized to heighten potency could be a new drug that causes other drugs to have 2-2000 times greater (piperine published effects) physiological
availability,

Quantify the cytoexterior amount of each kind of receptor at different cytotypes between prelongevized and longevized organisms like mice and double lifespan c elegans, then research and technologize organisms with the software quantified as optimal
amounts of those receptors, receptor type amounts could be adjusted with genetics, epigenetics or drugs, if longevity increase along with healthspan and wellness benefits are found then that is a new longevity technology, if it is beneficial to progeny
then the optimization of cytoreceptor kinds and quantities is a beneficial human, that is persons, that is people's germline enhancement technology

Gueu queue wueue is a lowercase e turned sideways half circle up an all right component e. Could moderate even further and be less e like, gueue with all the letters traverse and e rotated half circle up

New mathematical symbol transverse time mathematics notation, all rounded non-tapering tall banana at right with semicircular nub at west side, the tricircle, three overlapping circles at identical distance from each other, also possibly four 1/10 of
character height circles, optionally overlapping (kind of like 2019 AD Audi vehicle symbol) also with a soft rounded curve nontapering banana of full character height with the growing curve of the banana to the east

I think it is beneficial and optimizing that all new mathematical notation glyphs (characters) created be rounded forms, like blobby molecular orbital graphics I have seen.

A rounded curve making fractal equation combined with a discontinuous function causes a group of rounded soft shapes to appear as simultaneous embodiments

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Protein drug absorption of orally administered protein and peptide drugs like longevity drugs, an enteric coating or digestion decreasing protein coating, or liposome or othersome preserves protein drug until it contacts the actual GI tract membrane,
like I read there is a brush cyte at the surface of GI tract membranes that deacetylases sucrose, so an enteric coating, possibly a polysucrose, would only dissolve at the brush cytes, releasing the protein drugs right at the GI tract membrane, and only
at the gi tract membrane that could make protein drugs and peptide drugs absorption higher, making eentsier even more affordable doses possible, another possibility is having liposomes or othersomes detect and dissolve when they experience mucous at a
near membrane concentration, it is possible the mucous has different pH or different enzymes than the bolus at the GI tract, and that the chemistry of pH indicator colorants could be used to do reactions at liposomes that cause them to dissolve, or a pH
or mucous enzyme reactive protein could be at the reaction mix that makes the liposomes

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If you spray a coating of million year endoliths and other endoliths on a multimillion well yeast plate, do secretions from the endoliths cause the yeast to live longer when screened for fluorescence, where more fluorescent yeast have lived longer

Are some million year endoliths than others weller than others, perhaps there is a way to tell like reproductive frequency or secretion of chemicals to the growth medium, or rapidity as responding to a harmless stimulus like greater nutrient
concentration at the growth medium, both high wellness and the normal distribution of wellness at endoliths could be screened for new chemicals that cause greater longevity

Social companion robot who can be dismissed prompts people to tell them things they think would benefit other people and, absent paranormal risk, causing those beneficial things to happen, a white technology

Genetics of more frequently having good dreams while asleep, this could be tested as gene therapy on other primates who have hand language and say if they had good dreams, then tested on humans as gene therapy and if people like it making it part of the
human genome is beneficial, there are already mildly nootropic drugs that cause greater intensity of dreams and possibly more frequent dreams, they could screen a library of molecular variants, do brain scans of rats and find those with variously greater
variety of brain activation areas, and versions that activated the neocortex, nucleus accumbens, and dopamine neuron rich areas more, also at the drug that already increases dreams they could find out what genes it activates and then make new drugs that
activate those genes, although I do not think yeast dream they may have some of those genes and at a multimillion well plate could possibly be utilized to screen a library of millions of molecular variants

There is an inflatable dancing person sometimes used at advertising about 7 meters tall, it is possible this could be 22-34 meters tall with more fan activity and different fabric and some internal reinforcement, just turning it on could be an instant
antenna mast, it is remotely possible this could be used at high areas, particularly at the developing world, to be communications antennas, phone data antennas and internet would be beneficial, there is also a wide area WiFi called wi-max that could be
utilized, a wimax dancing person antenna could be placed on top of any building, preferably a tall building for placement in less than 300 minutes

Balloon lifted antennas are, I think published, it is possible helium balloons that last more than a year are engineerable, eleven layers of PTFE with some sprayed with cold plasma SiO2, a mineral layer, could reduce outgassing further, with 7 of the 11
layers cold plasma coated, PTFE or silicone grease between layers is a possibility as is a balloon full of 11 layer, more easily manufactured 100-300 cm diameter balloons, these would lift data antennas to arbitrary heights, Google had a blimps provide
internet project, perhaps with more affordable blimps that could function

Antennas could be kept aloft in the sky with drones that sequentially visit a sky antenna and dock to it, holding it up, two or three drones could take 40-90 minute turns docking at the antenna top and holding it up returning to a solar recharge station,
the drones might be larger as they could have batteries that power the antenna, or, just possibly they could bring a liquid fuel to a micro generator on the flying antenna to make more energy with less mass, the third drone would be if one of the other
drones was underperforming, flying phone and internet data or wi-max could bring more data to the developing world at $2000 for the drones, $300 for the data electronics, and $300 for the antenna, and at munipalities there would not be a solar array $,
with a solar array of 1 kW, that is about $600, and it is possible that is 300 watts of broadcast energy and 700 watts for the drones and batteries, or. Noting solar availability during just the day, about half that unless a 2kw $1200 photovoltaic were
used, that makes the flying data antenna $2600-3800, if another technology can halve that, like more affordable drones or lighter antennas made of silver plated polymer, or 1 year tanks of liquid fuel, about $1226/365 days (14 cents/kWh 8760 hours at
ground based generators then ground based generators could also have less up-front expense, less land requirement than solar, although at 1-2 kwh solar breaks even after a while, also I perceive the internet and phone data go to about 1/5 usage during 1-
6 am, suggesting fewer antenna stations are required and conserving 7% of the power making it about $70 more affordable to utilize

Longevity technology
The eentsiest genomes have 400 to 1000 genes, I do not know how many million year lifespan endoliths have, they could do a stochastic gene recombination with yeast to make t
Things that fill children with happinedd

--- SoupGate-Win32 v1.05
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The eentsiest genomes have 400 to 1000 genes, I do not know how many million year lifespan endoliths have, they could do a stochastic gene recombination with yeast to make millions or billions of yeast with genomes mixed with endoliths genes, at a liquid
culture, fluorescent yeast that fluoresce a greater amount the longer they have lived, published flow cytometry that processes 10 million yeast cytes per second could then also place high longevity yeast at a side channel and screen a billion yeast with
100 seconds and screen a trillion of the million year endolith yeast hybrids at 64.9 days, the new longevity genes products could be quantified as protein and receptor suggestive drugs and the 99.99999999th percentile of these endolith-yeast hybrids
longevizing genes could be genetically engineered into mice to quantify any greater longevity at the mice as well as being neutral or beneficial to wellness, healthspan and cognition

Things that fill children with happiness
A toy that is a psychometric, handheld toy that does hundreds or thousands of psychometric tests, as 14-40 question rapid fun bunches then asks the other questions on say a 100 question test later, deep learning AI could validate fun rephrasings of
existing psychometrics, quantitatively measured as being fun for children and increasing happiness,
The software could lead with a psychometric test that is the most fun and where the output always makes the person feel good about themselves (the myers Briggs is kind of like that), if the software can sense when the child is about to put the toy aside (
possibly keypress velocity, or with camera body language) then it can start displaying all fun psychometrics, that way the software which is previously quantified as being fun and making children happy is, I read more likely to be remembered as fun,
prompting more frequent utilization, at the parents option the data could be uploaded online, and also shared with CPU speakers, child-life optimizing and child-raising text software, and companion robots, this could also be, as a two or more person
connected tablet software toy causing of children to talk with each other about new things and rotate between children at timed intervals so everyone, notably introverts, gets their say about what they think and an opportunity to talk about themselves,
children with various opportunities for growth or who would benefit from rescuing could be identified, this might provide early warning on live-in boyfriends or other adult effects on children while simultaneously making the children happy, some
psychometrics, or nonpsychometric dialog, could cause children to divulge more confidences and the software could group and sequence questions to cause the children to divulge more about how they actually feel and report their own actions or the actions
of others more accurately, there is an outside chance that with popularity the software could suggest the child put a visible white and blue bodypaint form or wear a decorated hat to let other children at school they were compatible with that they were
open to coversation and play with children of compatible body paint or scarves, the software could also suggest play dates with other compatible children at the online component, and parents might like getting the toy as it causes the children to have
good new friends
This psychometric toy could also benefit adults at making friends and other benefits, a phone app for adults might be beneficial, also adults often see more people so going up to other adults with compatible bodypaint or scarves could be a normal thing
to do

My perception is almost everybody is compatible with MBTI ENFP that are at 70th percentile or above at minimal mental unwellness, other than perhaps FJ.

What about the 99.9th percentile of less likeability and social fluency, who will socialize with them? These people might sometimes be ISFJ, it is possible compartmentalized, organized activities of a physical nature like gymnastic spotters speaking
factually on J-valued improvements at activities that heighten their light triad amounts would be beneficial, fun, and growthful,

better child environment practices, genetic engineering, and social companion robots and prosperity make things better for children

Children and prosperity,
as a technology psychometrics could be utilized to find the most optimal dollar amount of allowances for children, allowances could have more than one dimension, every 7 days and also three times a year a larger lump sum is given that the child could use
as they prefer, like an investment, or a higher value thing, the lump sum could be the equivalent of half a day or a full day of a parent's earnings and be given regardless of behavior








Synthetic genome organism longevity


Longevity technology
The eentsiest genomes have 400 to 1000 genes, I do not know how many million year lifespan endoliths have, they could do a stochastic gene recombination with yeast to make t
Things that fill children with happinedd

--- SoupGate-Win32 v1.05
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Are there oceanic fungi, screen them, as well as their chemically separated homogenates for longevity chemicals with yeast, they may have notably different genetics and if collected at cold water, sparse nutrient areas could have much longer lifespans,
that could also function with cold water sparse nutrient ocean bacteria

Things that fill children's lives with happiness
It is imaginable that children that get an optimum duration of sleep with various optimal chronological amounts at different sleep stages are 7-19% happier (imaginably, as based on adult experience). A bed or camera technology could measure sleep
behaviors and duration. Then software like deep learning AI that had learned what amount of sleep, at what age, at what genome and psychometric data, would then communicate to the child and parents the benefits of different amounts of different amounts
of, and kinds of sleep. It is possible there are gentle things that beneficially prompt different sleep stages to optimize them, like a meal before bed, nonlyrical music customized to each sleep stage while asleep, the lighting between bedroom and
bathroom, a blanket that cools or warms, the presence of a body pillow as well as other things could be quantified as to the amount they modify sleep stage amount and duration to make the children happier and more well rested. This could also benefit
adults.

Children's shoes could have pedometers in them to measure activity. Software or deep learning AI suggests an optimal amount of activity, sometimes an increase, that causes 99th percentile happiness increase from the pre-pedometer measure of happiness

How often do people change their routine, and does that trend toward optimal, if a person always changes their routine towards something more optimal it is possible things become cumulatively better. Software could advise people on their routines and
deep learning AI could look at those at the 99th percentile of happiness, doing what they value, productivity, to find routined other people can make use of. About half of people are MBTI J and might gravitate towards routines

Semiconductor technology
Surface mount IC technology, pick and place robots could stack SMC components on top of each other, saving board space, having 14 micro contacts per upper surface, and having any one or few of them sufficient to carry the current, while engineered to
contact at all 14 heightens reliability, if metal Velcro is a thing then pressing them together omitting solder could be possible and adhere to engineering specifications, nonoxidizing metal Velcro heightens reliability and lifespan

MWI technology
Whenever you search for something and click on a search output item the software opens up an extra browser tab from finding the most benevolent and beneficial result (thesaurus similar meaning words) on the third through 9th pages of results, sometimes
people will view it, sometimes it will make them think, and sometimes they will learn about a less SEO optimized, less mainstream thing about what they are searching about, it is possible it will prompt benevolence and benefit, at the MWI these could be
different sites informing people of different things and causing different knowledge and different actions with a tropism towards benevolence and benefit from parsing the link descriptors, this is a browser add-on with mildly white and blue tropism

Regoogle, it makes Google or Bing better from parsing the first 24 pages and uses deep learning to put half of what the deep learning AI on your computer thinks you will like and half beneficial diversity, among those search results with the most
benevolent and beneficial thesaurus words

Software browser add-ons that address the 9 most popular sites and Imgur (a meme image site), deep learning AI at the browser notes the time you spend on each imgur image (rapid click through suggests lack of interest, mouse movement to read text and
comments suggests high interest) then with that data sample gives you the ability to view "My Imgur", that is graphic memes the AI thinks you will like based on previous dwell time at other images and deep learning AI' noted image matching ability as
well as text cues like body text and favorable language comments, this could be a part of ReGoogle or ReBing which could decorate each page with a graphic, a meme the AI thinks you will like, this could be modified at the configuration menu



Concentrating elements from seawater with microorganisms, is it possible to make spongelike charged proteins, possibly spaced beta sheets or similar with charged amino acids, or even more highly charged synthetic amino acids that microorganisms could
make, and at better technology move to the cytosurface like receptors, perhaps existing receptor genes could just have codon sequences that say make a bunch of ion-exchange resin like proteins at a location at the existing receptor gene and it would get
transported to the cytosurface

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Culturing the yeast and bacteria being screened for greater longevity being cultured at human body temperatures will make all the proteins function at the velocities they would at the human body

Use a flow cytometer on MEMS to find the most on specification ones

Things that fill children's lives with happiness

Photonics

Is there such a thing as a soliton at the MWI? Can any field support a soliton like magnetic and electron fields? Could a strong or weak force field soliton change the shape, radioactiveness or some other thing about an atom?

Do they use all three kind of waves, transverse ≈≈, compressive, and that other one with three or greater wave attributes at photonic communication like the internet through fiber optics like frequency, wavelength, polarization, also there is quantum
camera photon linking (entanglement)

Do isotopically pure fiber optics have greater transmissivity,

If a light absorbing and repeating semiconductor at fiber optic light repeaters is made with a three photon system material (like chlorophyll is a two electron system) does the two photon majority of three when sensed provide greater Shannon data
reliability at very far, few photons reaching the detector, fiber optic data repeaters

Does germanium oxide transmit light of completely different frequencies

Can the sides of a photonic waveguide, like those I have seen manufactured on ICs with undulating sides have the ability to take stray light and turn it into waves that use nodal effects to provide a continuous soliton bolstering, building, or rebuilding
field, overlapping beat frequencies outside of detector range might make a three phase power or root mean square shape but would contribute the distal wave squiggles that turn ordinary solitons into 100 times more durable dissipative solitons

Have they looked for solitons in interstellar intergalactic space, what causes them?

Could an impact driver tool, like at manufacturing use a soliton percussion wave to drive deeper, perhaps bringing more force to distant or distal area of a part and less distortion directly at the contact area, faster soliton jackhammers would be
operated less from greater efficiency at disintegrating things and there is a chance they are quieter, at ultrasonic welding would dissipative solitons permit more layers or greater thicknesses to be welded, at ultrasound images would gentle energies of
dissipative solitons, solitons, or partial 30% soliton characteristic waves permit greater depth or resolution, at causing cytes to absorb drugs I read they absorb more with acoustic stimulation, at deep organs could dissipative soliton acoustics be used
to heighten or localize gene therapy as well as drug absorption deep at the body, this also has applications to getting rid of tumors,

At petroleum reactor containers could solitons or dissipative solitons or partial 30% solitons from whistles on bubble cap trays send mixing energy far distances, external to container soliton generators are also possible, heightening efficiency

Could peaceful use soliton making explosives be produced

Nanometer, Micrometer to multimeter uses of explosive nitrocompounds are described as having uses at nanotechnology, could soliton micro and nanosized explosives cause greater action at a distance changing the shape of the math distribution of effect,
what is the effect of one protein-like but possibly other element, 100 kilodalton nitroprotein at energetic motionizing, kind of like 529 molecules of trinitrotoluene or less of motionizing

Soliton excavator teeth, it is possible that solitons or dissipative solitons could penetrate cm or meters into minerals making mini-cracks making material easier to gather or causing a preferred particle size, note the energy of the excavator working
previous normal amount compared with the energy of the transducer causing half as much excavator FMA might not be favorable at some transducer efficiencies , the explosions they use to make mineral fragments is a peaceful use of soliton producing
explosives

What is the most affordable way to produce mechanical energy solitons, custom shaped water hammer at a two fluid hydraulic system with an internal whistle, cams with novel curves, hyperrugged piezoelectric transducers, the WSU crystal, likely doped with
other elements, that is harder than diamond could be one, solenoids with custom shaped distal tips,

Ways to turn mineral to powder more efficiently would benefit humans, I read 2-3% of the earths energy use goes to powderizing rocks, bringing that to 1% provides the energy about 150 million people use annually, loading eentsy and medium chips together
then grinding might cause vertex pressure points to disintegrate faster causing preferred powd





Geotextiles



Automobiles

Petroleum geology technology


200 groups of 100 human and multicentury whale genes each at yeast, screened at yeast for greater lomgevity

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I read human Eunuchs live 19 years longer than other people, plasma mass fractions and tissue homogenate chemicals from cow, horse, pig, or rat eunuchs as well as ordinary organisms could be compared to find chemical differences, then the different
chemicals administered to c elegans to find out if any had longevizing or modulating effects, also noting an old rat and a young rat with connected circulatory systems causes greater rat youthfulness (as well as possibly longevity, I do not remember
what it said) they could test eununch rats with their circulatory systems linked to ordinary rats of the same age to find out if there were longevity effects,

similarly there may be longevity chemicals sequential to the mTOR effects of rapamycin, published as making mice live 60% longer, connecting the circulatory systems of old rats that were, until 54 hours previously, on rapamycin, to those of old rats of
the same age could find out if there were non mTOR longevization chemicals circulating at the previously rapamycin treated rats

The difference between the human age equivalent of 60 year old normal rats and 60 year old multimonths of previous rapamycin, rapamycin treated rats could be characterized as to their electrophoretic physiochemical difference, and the notably different
chemicals tested on yeast and c elegans for longevity effects

The electrophoretic physiochemical difference between 30 and 40 year old human equivalent age rats and rapamycin treated 60 year old equivalent rats could be characterized, the most maintained physiochemicals from 30 year old to 60 year old rapamycin
treated rats (as compared to 60 year old untreated rats) these physiochemicals could be tested on yeast and c elegans, if large mammals on rapamycin are utilized then that could be a plentiful source of chemicals to test mice or shrews with




The difference (a list of only which are shared) between all the chemical differences between young and old test mammals, and eununch test mammals could create a more rapidly testable list of chemicals that heighten longevity

Electrical engineering technology

Mechanical engineering technology
Standard sized containers at trucks effect the size that machines loaded on them can be, doubling the length, height and increasing of those containers without going to specialized "oversize" flagging would make it so larger machines, machine parts and
other things could be transported, it could be that driverless automated trucks could transport these larger standard containers with minimized (less than human) risk, and stay away from other drivers, also, possibly adjusting velocity or idle time to
drive when the fewest other cars were around is possible, that would cause new efficiencies at distribution

Trucks, like driverless trucks or other trucks could have weights placed at the bottom of the wheelframe or carriage to make double stacks of containers compatible with stability

I have seen bread trucks three containers long, double stacked containers at these would make them 6 times more efficient than one truck carrying one container, it could be that one or two powered wheels more at the second and third trailers would make
it so driverless trucks could do the physics to do this harmlessly, the minimal size, minimal weight one is sufficient wheels could be electrically powered from the engine on the trailer-truck

Electrical engineering
a new way to find higher performing components in a batch, on part of an assembly line they could have an addressable conductive fabric under every item, the items could have their own individual id number and every part tested to find the 95th
percentile of overclockability, leading edge cleanness, and at analog parts onspecificationness, these could be pulled aside with their individual visual identifier and described as a separate product

Longevity technology
Utilizing green fluorescent protein to describe how long an aorgsnism like yeast has been alive, when genetically engineered to make GFP, the longer a yeast has lived the more GFP it produces and a camera can scan a grid of wells identifying which one
has the longest living yeast, similarly at c elegans this is possible, engineering yeast and c elegans to make a couple other colors of blue and a couple other colors of green could track multiple metabolic activities of the c elegans simultaneously, if
it is possible to look at muscle mass or something that accumulates with motion then the amount of motion might be associable with wellness or healthspan

At c elegans it might be possible to genetically engineer a near transparent variety that made green or blue fluorescent at its heart so the 96 well plate scanning camera could tell if the heart was still beating and if it is still alive, this would get
rid of having to physically probe the c elegans to see are alive, gentle ultrasonics, or infrasonics has been previously suggested as a way to do this as well

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Epithalon, AEDG is a longevizing pineal peptide, i read it causes 24% greater longevity at rodents, as a pineal peptide It might be continuously active, or pm or am most active at the pineal of living organisms, and could have greater longevizing effects
when administered with heightened PM or AM body concentrations, it is possible that the things Epithalon activates, like receptors, at the brain and body are also longevizing when separately addressed, and finding other drugs that activate those
receptors creates new longevity drugs, also I read that antibodies to receptors can heighten, or decrease their effect, so it is possible a beneficial immunization based on these receptors could be a one dose lifetime longevity drug (or at least as long
as the immunization persists, some are multidecade),
finding out what the epithalon receptors are produces a new place to make new longevity drugs be active at, new genetics of longevity, finding out what organs and tissues and localizations they epithalon receptors are located at describes organs and
tissues with high-effect longevity function, epithalon might effect something not previously considered as longevity related, like lungs, and provide a new beneficial area to make longevity drugs and technologies around, if epithalon has non-receptor
direct effects like nucleus or cytoplasm effects, as well as if Epithalon has effects on neurons of only one particular neurotransmitter type, notably if Epithalon mainly effects one neurotransmitter then other drugs that effect that one neurotransmitter,
possibly with brain localization, could be new longevity drugs,

if epithalons pineal production is like a sunrise chronology like function, then a different pineal peptide might be like a PM "activate the program to be well rested" peptide, and supplementing both could be beneficial

If Epithalon longevizes organisms without a pineal gland like yeast, c elegans, as well as daphnia and queen bees, then its longevization effect could be linked to activity at what I read are called highly conserved genes that differ comparatively not
very much between organisms, finding out what those genes are provides a new group of longevity genes as well as specific protein gene products that could be longevizing, if Epithalon only makes things with pineal glands live longer then pineal gland
genetics could be longevity genetics and human SNPs and alleles could be compared to find the most beneficial pineal gland genetics

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Klotho is a kidney gene that makes mice live longer and be twice as effective at finding things when genetically engineered to make a lot of it , it is possible that organisms that utilize their kidneys and brains a bunch simultaneously could have more
effective versions of klotho, dolphins, whales and sea otters are organisms that may have this feature from gulping ocean water and processing it, beavers might gulp a lot of freshwater and as they build things may benefit from higher cognitive ability,
klotho could, possibly or possibly not, contribute to beavers living 35 times longer than mice, squirrels which have orders of magnitude greater ability at remembering and finding objects, to my perception, compared with mice I previously mentioned as
Klotho gene versions, with possible optimizability, as well as slight variations on the gene protein product as a protein drug, a longevity drug as well as a variation as a protein drug nootropic

Longevity technology

Klotho external protein is mentioned as receptor less but concentrating at a word like sialogangliosides, that suggests sialogangliosides could be tested as longevity drugs and nootropics

Supercentensrians were tested and found to have about 1.5 times greater likeliness of having the most favorable variant of the klotho gene

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Klotho is a kidney gene that makes mice live longer and be twice as effective at finding things when genetically engineered to make a lot of it , it is possible that organisms that utilize their kidneys and brains a bunch simultaneously could have more
effective versions of klotho, dolphins, whales and sea otters are organisms that may have this feature from gulping ocean water and processing it, beavers might gulp a lot of freshwater and as they build things may benefit from higher cognitive ability,
klotho could, possibly or possibly not, contribute to beavers living 35 times longer than mice, squirrels which have orders of magnitude greater ability at remembering and finding objects, to my perception, compared with mice I previously mentioned as
Klotho gene versions, with possible optimizability, as well as slight variations on the gene protein product as a protein drug, a longevity drug as well as a variation as a protein drug nootropic

Longevity technology

Klotho external protein is mentioned as receptor less but concentrating at a word like sialogangliosides, that suggests sialogangliosides could be tested as longevity drugs and nootropics

Supercentensrians were tested and found to have about 1.5 times greater likeliness of having the most favorable variant of the klotho gene

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With higher IQ linked to greater longevity they could do brain scans of super centenarians and find out if their actual brain mass at each millimeter of brain structure varies from others, quantifying positron emission tomography amounts of radio
labelled chemicals the supercentenarian variation at what amount of actual neurotransmitter chemical is where as well as neurotransmitter receptor density is describable, and could be associated with longevity, and longevity chemicals active at mouse
brains, complementary to while being different than nootropics could be screened and produced; non cognitive areas of the brain could also be heightening longevity (Epithalon, a pineal peptide, is published as causing 24% greater longevity) new longevity
drugs developed to address brain areas that might be outside cognition are also beneficial



Screening stimulant molecules to find out if there are longevity heightening molecular variations:



On finding 99.9 th percentily of longevity heightening stimulants at 96 well plate fish, screen the 99.9th percentile stimulants on mice, quantify absence of emotive or also social conflict, optimally less than the amount of median unmedicated mammal
emotive and social conflict, also beneficial is quantifying mouse actions, communicating, feeling happy, play, and willingness to travel at open spaces, another the benefit of a longevity producing stimulant could be quantified conviviality, also mating
frequency,



Stimulants at less than a behavior changing dose could also cause greater longevity particularly screened as a library at yeast as well as c elegans;



At perceptible stimulants a voluntary human experimental participant verifies the longevizing stimulants as pleasant and fun then marmosets at age batches verify longevity effect while having fun



It is beneficial to

Screen longevity stimulants as beneficial or neutral to the fetus, or are also absent passing the placenta



Rapamycin is published as causing 60% greater longevity as well as higher cognitive performance at 126 ppm at mice, I took some at kind of near 24-63 ppm and noticed it made me kind of excited so I did not go to sleep, so I started taking it, when
possible, before or near noon, it is possible that screening a library of rapamycin molecule variations to find nootropic or also beneficial prosocial stimulant versions could be even more longevizing than rapamycin (60% rapamycin with near 20 from IQ is
80 pct longevity heightening) stimulant ability of rapamycin molecule variants could be screened at c elegans to see how fast they move around before quantifying the effects on longevity, social behavior and cognition at mice;

attaching a nootropic or stimulant moiety to rapamycin could put the 21% greater longevity from higher IQ with the 60% longevity heightening from rapamycin to make a drug with 80 pct greater longevity effects that could be quantified at age batched
marmosets



Epinepherine I heard, is aversive, it might be linked to heightened cognitive function as I perceive I read some humans get hyperfocused, more simultaneously aware, and mentally and physically faster possibly at a voluntary epinepherine producing
activity, screening a library of numerous epinepherine variants could find a fun, harmless, pleasant, peaceful, multiarea beneficial longevizing version



Organoids as tissue culture forms that could be utilized toscreen chemical libraries, positron emission tomography on tray stacks, 3-7 mm per well, 49 rows columns and stacks per positron emission tomography scan occurrence scans 117,000ish verified as
being absent isness organoids



Is a way to verify absence of presence of being, like at 3mm neuronal brain-like nuggets like organoids to position the thing being qualified as absent presence of being as a quantum system observer, then if the system is observationally resolved there
is possibility of presence of being, if the thing is absent quantum resolution then it is possible the object being qualified as to absence of presence of being like an organoid is either not being attentive, like a human that is so romance focused they
fantasize about their girlfriend while looking at the quantum apparatus and do not notice what is going on, or rather than nonattentive it is possibile the organoid is actually absent presence of being, while quantum resolution as compared with a 3mm
nugget of a different tissue would make it so they built different organoids that were absent quantum resolution capability



organoids with reduced likelihood of having presence might be built with a matrice of neurotransmitters, neuron types, or morphologies omitted; screening things at organoids matricized to have serotonin with acetylcholine but not dopamine at one group
of organoids, while a different group of organoids has a different neurotransmitter matrice, causes nonbeing form when screening a million organoids at chemicals like beneficial longevity drugs;



Longevity technology as well as new longevity drugs



Nootropics

Scientific American might say button pressing reaction interval is more predictive than iq, or possibly fully elucidates iq causing greater longevity, that makes it so that stimulants as well as nootropics could have a longevizing effect; screening
molecule variants of stimulants on yeast, c elegans, drosophila and mice to find stimulants that cause greater longevity is beneficial



At mice, screening stimulants to find those that are prosocial, peaceful, creative, productive, as well as fun is beneficial, human study participants on one occuremce doses could also be quantified as to various positive measures of beneficialness



Notably, different stimulants function different ways. Noting the button press predictor of longevity it is possible that stimulants that effect the peripheral nervous system, even those that do not traverse the blood brain barrier could be longevity
drugs, CNS stimulants could also be quantified as to longevizing effects as could stimulants that effect both, also I perceive there are other nervous systems like somatic sensory nerves that could have stimulants focused on them and quantified as to
longevity effects



Perhaps localization (published and new cyte and tissue localization technologies, as well as cytomembrane transport moieties) of stimulants also contributes to longevity effects, particularly longevity heightening effect nerves, possibly the vagus, the
pancreatic nerves as well as spinal cord; localization could reach these while omitting effects on the heart like rapid pulse or blood pressure effects, decreasing any deleterious effects



Stimulants could function based on different parts of neurons and it could be possible to find neuron areas that create a modality of stimulant type, a stimulant theme to make new screenable libraries with that heighten longevity; dendrite active
stimulants. Synapse active stimulants, myelin enhancement that is stimulating or also makes button pressing reaction interval, as well as organism wide neural reaction interval more rapid are all screen able as different possible longevity drugs;

Screening stimulant molecule varieties that are lipiphilic, hydrophilic, neutralphilic, as well as different sizes of AMU molecules are possible screenable libraries to find longevizing effects; also the 99.9th percentile of longevizing activity at c
elegans or 96 well plate vertebrate fish stimulants could then be screened on mice, possibly sequentially every 72 hours to find beneficial benevolence, empathy, kindness, peacefulness, cognition, fun heightening molecules, then the quantified effects at
mice could produce beneficial longevity heightening stimulants that voluntary human experiment participants could quantify with things like reactions to software and fMRI similarity to humans at the 99.9th percentile of beneficial mind, feeling,
behavior and cognitive capability;

Noting the higher velocity reaction intervals link to longevity it is possible nonchemical nerve velocity heightening technologies could be longevity technologies; microvoltage or micro current stimulation, EEG like non CNS electricity directing and
causing EEGish frequencies like those recorded at 14 year olds could cause non CNS nerves to make the kinds of reoccurring waveforms at the same locations as particularly youthful, or actually (14 year old) youthful people, entire organism EEG like
stimulation is described at the online site with my material on it, possibilities are ankle as well as wrist wearable through-body stimulation as well as possible electrochemically active .1 to 1 mm CPU size networked electrical waveform network making
decal technology



Making screenable library variants to find longevity heightening stimulants based on these chemicals:

Modafinil

ADD drugs,

Phenylethylamines, pikhal shulgin

MDMA, prosocial. fun

Stimulant molecular variants of rapamycin

CART peptides

Ephedra

Epinephrine molecular variants that are pleasant

nonhabituating +Caines, procaine has about one study quantifying wellness and longevity benefits, screen 1000 nonhabituating -Caine's at outdoor mouse dorm mice



Screening a million stimulant molecule variations on yeast could find longevity drugs even though yeast do not have nervous systems, among the possibilities are multifunction molecules with another longevity mechanism HAEE is an 10HDA(longevity) like
molecule that causes anxiolytic and nerve healing effects, it is possible there is a stimulant molecular variation of HAEE, possibly even a decanoic acid ester, with simultaneous 10HDA longevity effects, HAEE anxiolytic and nerve healing effects and
stimulant based longevity heightening effects; similarly 10HDA is an HDAC inhibitor, it is possible some variety of an HDAC inhibitor or other epigenetic modifying molecule that causes genetic availability of spontaneous stimulation, heightens stimulant
ability, or is also a molecularly active stimulant as an actual chemical



Longevity technology as well as new longevity drugs



Nootropics

Scientific American might say button pressing reaction interval is more predictive than iq, or possibly fully elucidates iq causing greater longevity, that makes it so that stimulants as well as nootropics could have a longevizing effect; screening
molecule variants of stimulants on yeast, c elegans, drosophila and mice to find stimulants that cause greater longevity is beneficial



At mice, screening stimulants to find those that are prosocial, peaceful, creative, productive, as well as fun is beneficial, human study participants on one occuremce doses could also be quantified as to various positive measures of beneficialness



Notably, different stimulants function different ways. Noting the button press predictor of longevity it is possible that stimulants that effect the peripheral nervous system, even those that do not traverse the blood brain barrier could be longevity
drugs, CNS stimulants could also be quantified as to longevizing effects as could stimulants that effect both, also I perceive there are other nervous systems like somatic sensory nerves that could have stimulants focused on them and quantified as to
longevity effects



Perhaps localization (published and new cyte and tissue localization technologies, as well as cytomembrane transport moieties) of stimulants also contributes to longevity effects, particularly longevity heightening effect nerves, possibly the vagus, the
pancreatic nerves as well as spinal cord; localization could reach these while omitting effects on the heart like rapid pulse or blood pressure effects, decreasing any deleterious effects



Stimulants could function based on different parts of neurons and it could be possible to find neuron areas that create a modality of stimulant type, a stimulant theme to make new screenable libraries with that heighten longevity; dendrite active
stimulants. Synapse active stimulants, myelin enhancement that is stimulating or also makes button pressing reaction interval, as well as organism wide neural reaction interval more rapid are all screen able as different possible longevity drugs;

Screening stimulant molecule varieties that are lipiphilic, hydrophilic, neutralphilic, as well as different sizes of AMU molecules are possible screenable libraries to find longevizing effects; also the 99.9th percentile of longevizing activity at c
elegans or 96 well plate vertebrate fish stimulants could then be screened on mice, possibly sequentially every 72 hours to find beneficial benevolence, empathy, kindness, peacefulness, cognition, fun heightening molecules, then the quantified effects at
mice could produce beneficial longevity heightening stimulants that voluntary human experiment participants could quantify with things like reactions to software and fMRI similarity to humans at the 99.9th percentile of beneficial mind, feeling,
behavior and cognitive capability;

Noting the higher velocity reaction intervals link to longevity it is possible nonchemical nerve velocity heightening technologies could be longevity technologies; microvoltage or micro current stimulation, EEG like non CNS electricity directing and
causing EEGish frequencies like those recorded at 14 year olds could cause non CNS nerves to make the kinds of reoccurring waveforms at the same locations as particularly youthful, or actually (14 year old) youthful people, entire organism EEG like
stimulation is described at the online site with my material on it, possibilities are ankle as well as wrist wearable through-body stimulation as well as possible electrochemically active .1 to 1 mm CPU size networked electrical waveform network making
decal technology



Making screenable library variants to find longevity heightening stimulants based on these chemicals:

Modafinil

ADD drugs,

Phenylethylamines, pikhal shulgin

MDMA, prosocial. fun

Stimulant molecular variants of rapamycin

CART peptides

Ephedra

Epinephrine molecular variants that are pleasant

nonhabituating +Caines, procaine has about one study quantifying wellness and longevity benefits, screen 1000 nonhabituating -Caine's at outdoor mouse dorm mice



Screening a million stimulant molecule variations on yeast could find longevity drugs even though yeast do not have nervous systems, among the possibilities are multifunction molecules with another longevity mechanism HAEE is an 10HDA(longevity) like
molecule that causes anxiolytic and nerve healing effects, it is possible there is a stimulant molecular variation of HAEE, possibly even a decanoic acid ester, with simultaneous 10HDA longevity effects, HAEE anxiolytic and nerve healing effects and
stimulant based longevity heightening effects; similarly 10HDA is an HDAC inhibitor, it is possible some variety of an HDAC inhibitor or other epigenetic modifying molecule that causes genetic availability of spontaneous stimulation, heightens stimulant
ability, or is also a molecularly active stimulant as an actual chemical



It is published that longevity goes up 21% at the upper 32% (including higher amounts) of IQ, also longevity and being alive things that could likely be brain processed, like if a romantic partner is alive and the amount of friends as well as the social
experience of a person effect longevity; drugs and genetics that enhance brain function are longevity technologies and drugs;



New longevity drugs based on nootropics (smart drugs), Screen a million or more nootropic molecule variants at yeast, c elegans; they may have longevity molecule actions that complement their cognitive effects, then screen the 99.9th percentile of
longevizing nootropic sourced molecules on mice to find those that simultaneously heighten longevity, subjective well being as well as cognitive ability to make beneficial new human drugs



Phosphatidyl serine and variations as nootropics as well as quantifiable longevity drug; other phosphatidyl amino acids and different molecule alkane lengths could be screened as a library



Screen a library of a million nootropic molecule variants and find the molecules that simultaneously heighten longevity, subjective well being like happiness, and cognitive function, then test the 99.99 percentile of them on mice, make them human drugs



All the greater than 100 neurotransmitter genes and all the brain morphology genes could be characterized as to their effect on longevity, heightening subjective well being and kindness as well as heightening cognitive ability; the simultaneously
multibenefical effect chemicals, like proteins, the genes make are library screened as protein drugs, those at the 99th or 99.9th percentile of multi beneficial effect are then beneficial human drugs;



it is also possible that among the greater than 100 neurotransmitters there are three where receptor activation is of greatest benefit as well as three where receptor activity decrease causes benefit like greater longevity, happiness as well as cognitive
ability, drugs that effect these nifty and antinifty neurotransmitter types are then longevity, subjective well being, as well as cognitive ability increasing drugs, and genetics of the nifty neurotransmitters are genetic enhancement opportunities at
humans as well as are the antinifty neurotransmitters activity being genetically reduced, which then heightens longevity or also happiness or also cognitive ability at humans



Bile acids cause yeast to have doubled longevity and increase the maximum age attained; screening a library of a million molecular variants on lithocholic acid at yeast is a way to find new longevity drugs; Finding the 99.9 the percentile of molecules
that heighten longevity at yeast then screening them at fish as well as mice, then making human drugs creates new longevity drugs; among numerous molecules variants screenable, along with combinatorial approaches, topology theme variations (undulating
3dness at molecules, near planar molecules, rapidly or gradually repeatedly changing shape (like chair boat at benzene), possibly there are variations at hydrophobicity that happen to also be orders of magnitude differenct from each other at
lipophilicity, dimerization at different sides of the molecule, protein versions, that to my perception can actually imitate few AMU drugs, making the distal thing that looks like a butyl to be propyl, heptyl, 6,7,8,9,10 C long (notably longevity
molecule 10HDA(10H2DA) could be the distal thing), making the cyclohexane like parts of the molecule unsaturated (C=C areas, like partial benzenes) as well as making them cycloheptyl (7 atom circle) vesions at some of them, removing or replacing the
methyl branch with an ethyl, propyl or other lipophilic alkane, changing the =O at the ester to a sulfur, as well as replacing the carboxyl with an amide (less hydrophilic), screen able variants like fluorine or other halogen where the hydrogen's are (
fluorine might be notably hydrophobic from the teflonization I perceive possible, also some fluorinated drugs have 1000 times greater activity per mg, enhancing pills/dosing as well as heightening affordability possibly 1000 times, also ethynylization,
noting lithocholic acid is cholesterolish and that ethynylizing cholesterolish sex hormones like progesterone makes them hundreds of times more active and active at a few hundred picograms per human dose; noting that sex hormones are cholesterolish,
lithocholic acid variations with similarity to the published longevity drug, nonfeminizing 17 alpha estradiol which causes 11% greater longevity could be among the screenable variants



Complementing screening a library of lithocholic acid variants, making radiolabelled versions and at the 14 most longevizing variants out of a million find out which cytoareas, receptors, as well as genetics the 99.999th percentile of heightening
longevity variants effect



three or fouteen genes producing differing bile acid molecules linkable to human longevity could be longevity genes

Nootropic stimulants

Longevity technology



At longevity chemical and drug screening is also possible to utilize informed, voluntary, capable, humans, that is persons, that is members of groups of people, that is homo sapiens as voluntarily participating paid participants: utilizing psychological
testing it could also be possible to heighten the happiness of the volunteers; it is possible to utilize only 70th percentile or greater of persons at their society's quantified feeling and thinking that they have options, surpluses, and other
opportunities:

A person making the reusable psychometric product, likely software, finds people above the 70th percentile of fiscal resources, as well as above the 70the percentile of preferred amount of fiscal flows at that society, and quantifies them
psychometrically, then at a different group, the group of people that would like to participate, at that group of people they also find the people at the median quantified feeling or above, of that of the 70th percentile group as to their feeling
fiscally of perceiving they are median or above at big 5 psychology test measured mental wellness, they are also screened on if they are at or above the society's median at both intelligence and educational hours experienced; these people perceive they
are doing well, do what they offer, can comprehend the purpose, documentation risks and benefits of being a human experimental subject; heightening the happiness of the participants is also possible, a 16 to 40 item optional psychology test is available,
the quantifications from they test have an r value of predicting the effect of experiment participation among people replying at various ways on the psychological test, then they get to participate based on their percentile of how much happier they are
projected to be, that is, their quantifiable subjective well being, from participating as a human test subject at that actual experiment;



I favor financial compensation to humans that voluntarily participate at scientific studies including medical studies.



Actinomycetes also is modified to be a nutrient source, as well as possibly a habitat for the fungi and bacteria that globally produce longevity heightening drugs that are effective on humans as well as numerous other organisms, that way from the fungi
and bacteria living at the actinomycetes that lives at the earthen particles(dirt) the earthen particles continually, at minute amounts, like the amounts reaching leaves of plants at 2019 AD earth, cause the surfaces of plants to have longevity chemical
and drug molecule producing bacteria and fungi on them, possibly as entire fungi and bacteria as well as spores, noting the bacteria and fungi are harmless to the plant unless kept wet with unmoving water for 72 hours, noting that rain is moving water,
rather than the unmoving water that accumulates bacterial and fungal chemicals various lengths of rain omit causing the fungi and bacteria to digest the plant; the fungi and bacteria grow, activate, and make longevity drugs and chemicals when at unmoving
water 72 hours;



Rapamycin at 126 ppm that causes 60% greater longevity causes more mouse head lifts as well as better cognitive performance; possibly, it could be that head lifts are moments of noticing, or a pleasant mood causing the action; as a human taking about 40-
60 mg of rapamycin every 24 hours I noticed near sleep hour rapamycin causing being too slightly enthused and alert to sleep, while socializing while it was light I perceived I responded to the other person more promptly, was absent any new or novel
emotional valence, and I experienced a moment when I felt I would have liked it if the person I was socializing with said funner newer things more rapidly, but that was like a few seconds; I experienced the rapamycin as being emotionally non modifying,
less stimulating than caffeine, as well as harmless; it brings up a technology of screening longevity drug molecular variants on their projected and actual effects on beneficial voluntary being, form and activity at human mind and behavior;

Screening a library of longevity drugs as to behavior effects, presence of being, as well as being physiological wellness heightening or wellness neutral at 72 hour dosing technology: Screen a library of perhaps 100,000 rapamycin or other longevity drug
variants at say 33 mice, with sequential screening of the longevity chemicals to characterize the mice' behavioral, social, fMRI, Positron emission tomography effects; one different chemical per each 72 hours, with the mice on video and their tissue
scanned a couple times, is near 300 chemicals quantified per mouse, at a 2019 AD unmedicated mouse; so that is 100k longevity chemicals sequentially quantified with 40ish mice,

To find pleasant or also neutral behavior and mind effect longevity chemical molecules the mice could be screened for a few hours of being medicated at group size: one mouse, before screening any particular chemical molecule on the 8 mice per molecule
that generates a p<.05 p value, screening the longevity chemicals at mice to verify beneficial positive or neutral effects on mind and behavior prior to characterizing and screening them at marmosets makes it so the majority of mice and the primates have
beneficial, positive, or neutral mind effects and behavior effects; noting these longevity drugs are technology to benefit humans, that is persons, that is members of groups of people that is homo sapiens quantifying and screening to find beneficial
positive effects has actual value;



Noting the longevity chemicals are longevity beneficial, 33 marmosets could screen 700k molecules or higher amounts sequentially while providing primate data that could be more predictive of human prosocial, pleasantness of experience, as well as a
variety of beneficial things like actualized behavior as well as mind and feeling and sustained presence of benevolence, kindness, empathy behaviors and ways of mind as well as fMRI of mind (like find 99th percentile benevolent empathic kind humans, do
fMRI, then at the marmosets note which longevity drug molecules align the fMRI of the marmosets with those of 99th percentile benevolent, empathic, kind humans; also at a different quantification find the longevity drugs that cause, at the marmosets,
actual behavior or also fMRI well above the human actual behavior or also fMRI at greater than the previous unmedicated median voluntary amount of: sharing, mating success, above median social fluency, initiating what to a human would be friendly contact,
big 5 psychology test openness to experience, conscientiousness, mental wellness, as well as fMRI of creativity



Making longevity drugs globally available, the 24 most frequently occurring kinds of bacteria as well as fungi that live on wet decaying leaves, also wet decaying grass are engineerable with CRISPR/cas9 gene drive to make longevity drugs, the most
frequently occurring soil bacteria, among them actinomycetes, are also gene drive modifiable to make longevity drugs, making dirt water longevizing, fungally produced rapamycin, Epithalon AEDG peptide, mTOR decreasers, senolytic fisetin, e coli
producible antibodies cause insulin like growth factor 1 reduction, decreased response at the ILGF-1 cytosurface receptor from antibodies on it, are all producible at organisms and gene drive at organisms that cause wet plant material to decay; the
person just puts some water on plant parts, puts it in a bag and when the sweetness peptides the genetic engineering produces make it taste delicious, perhaps with an enzyme that neutralizes other flavors, the longevity drugs are orally utilizable





Also mTOR decreasing active proteins

mTOR receptor response reducing active noncyto nonmacrophage glomming of entire cyte receptor glomming antibodies



Screening longevity chemicals and drugs sequentially, when the 100-700k chemicals are sequentially screened with the mice or also marmosets at a weather ameliorated (canopied) outdoor mouse dorm as well as outdoor marmoset dorm then the mammals can move
and socialize heightening social data value



Lithochilic acid causes yeast to live twice as long and heightens maximum lifespan, screening a million molecular variations on lithocholic acid could create new longevity drugs; at humans, humans that have greater amounts of lithocholic acid have higher
cancer risk, I read mice tend to get cancer more than humans so when screening the 99.99th percentile of the most longevizing molecular variants of lithochilic acid it is possible a mammal lthat has less cancer risk than mice, as well as age batched
marmosets could be a better model for quantifying longevity increase; an online item says lithocholic acid is toxic but not at humans when medically adminsteref, it is also possible that at humans the coadministration of cancer risk reducing longevity
chemical like metformin or rapamycin could cause the actual cancer risk of rabbits as well as mice as well as marmosets to be less that that of completely unmedicated rabbits, mice, or marmosets; cholesterol risks could be reduced to less than those of
unmedicated mammals with the high density lipoprotein cholesterol reducing drug simvastatin which is published as having a longevity benefit, although possibly from heightening healthspan



Alibaba lithocholic acid dose; at humans it is published that 30mg/24 hours of ursolithocholic acid causes 16.86 micromolar concentration ( up from .05), and bile acid amount went up to 17.21 (all the bile acids) suggesting that 50 micromolar
concentration like the yeast that live twice as long is a 89 mg/24 hours; although it might not be a plausible dose: the paper says 30 mg of ursolithocholic acid causes only .22 micromolar concentration of lithocholic acid at humans; perhaps the 17.21
millimolar concentration of all kinds of bile acids, 6 of which make yeast live longer, compensates for that; another paper says ursodeoxycholic acid (a hydrophilic bile acid at ( 30mg/kg each 24 hours) makes previously unwell humans 2.1times more likely
to omit being alive than unmedicated humans, note though that that is at 30 mg/kg/24 hours so is 70 times higher than the 30 mg makes 17 micromolar concentration at humans so it is possible that a 1/70th dose has only a 1.03 (compared with one)
likeliness of causing not being alive;



it is possible that doing correlative studies of human longevity from the varying amounts of bile acid that occur at the different phenotypes at the human population could find genes that make concentrations of bile acid molecules different than others,
if there are versioms of three or fourteen different kinds of genes that effect bile acid actual different molecule amount then those three or fourteen genetic variations, their SNPs, alleles, and copy numbers could correlate with different human
longevity, also they could look at the genetics and measured amounts of bile acids at super centenarians to find out if there is a more longevizing genetics of bile acids or amount of bile acids





I do not know if there is a yeast compensation number when calculating a human dose from a yeast dose like the order of magnitudish less drug compensation number at mice



Write about lithochilic acid online like longevity.org

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Rapamycin is a nootropic that can heighten laboratory mammal cognition and can keep me awake, brain positron emission tomography could find out which neuron types, and at what brain location these effects occur from, other nootropics that activate these
areas could be screened for longevizing effects, also if rapamycin is concentrating at some regions of the brain, or some neurotransmitter types and not others then a molecular variant of rapamycin that goes to all brain areas and all neurotransmitters
could be found



Longevity gene, neuron types where one neuron uses a particular neurotransmitter or just all the cytes at the body could use epigenetic modification drugs to make fewer mTOR receptors and possibly increase the amount of AMPK receptors at neurons, causing
the CNS to be more youthful possibly causing longer duration of youthful mind, and youthful cognition, and youthful emotion, cardiovascular system cytes could also be beneficial, causing greater longevization, youthspan of the heart and vasculature, this
could be a one dose drug that prevents cardiovascular disease



Create epigenetics that reduce activity of mTOR receptor producing genes, and possibly heighten production of AMPK from AMPK genes, possibly through screening a million or to find an even more optimal epigenetic modifier, tens of millions of molecular
variants of epigenetic modifying molecules to one that is most specific to downregulating mTOR, and up regulating AMPK, this could have multi generation longevizing effects, germline or also oocytes and spem modification to have the epigenetics of
longevity is beneficial



Modifying the genetics of cytes used at nuclear transfer to oocytes to have mTOR epigenetics that cause greater longevity

Liposomal ultra micro reactors

Aluminum or other atom hydrophilic or electrically charged head, or at another solvent like NH3 or DMSO, Or silicone oil, charged silicone distal electronegativity oil, make liposomes or things like silicosomes with reactants at the liposome or
silicosomes cores, sequential liposome or silicosome dipping might even combine reactants that are non able to occupy the same flask, then a detonation, warmth occurrence, photochemistry, like lasers event, or radiation occurs and the comparatively few
atoms interior to the liposome react to form a product at the core of the liposome, liposomes are kind of see through and liposomes can be sorted with a spectrophotometer at a thing like a flow cytometer, or possibly liposomes or silicosomes could have
surface charge that varies with core contents possibly from making the silicosome with 1/100th highly C=C saturated with NH on it or zubbles (TM a kind of plaything) like chalcones, which are so responsive that without disintegrating they change color
based on surface tension) then based on what is in the liposome the surface chemistry differs facilitating sorting, a trillion liposomes with 1000 reaction production product molecules each makes about 2^14 atoms or a billionth of a mole, at a 100 amu
product that is 1 microgram of product, flow cytometry to centrifuge



Silicosomes can be made with solventophilic heads and multimers with electronegative (like nitrogen, phosphorus, metals, Se ) atom heads, it is possible to omit carbon funkiness (what happens after an actual lipid liposome is warmed or disintegrated with
light or radiation), the non interactivity of the reactant molecules with the Si silicosomal interior perimeter makes things cleaner



The reacted silicosomes do a laser spectroscopy and flow cytometry like traversal of a tube and are sorted into products, so a reaction that yielded 100 products then produces 100 different separated products, possibly a million at a microfluidic device (
a million channel microfluidic chip I read about), and if these are products like longevity chemicals they can then move to an organism area to find out if they are longevizing, so 1 million varieties of halogenated rapamycin can be silicosomal reaction
produced, spectroscopy sorted, then applied to yeast or human tissue culture microfluidically, a trillion silicosomes could be 1 microgram of product, at a 300 mm wafer with 10-100 billion wells per chip, 1 million variants of longevity molecules tested
per notable source, things like endolith chemicals autovariationized is 10k sou



Longevity technology

Yeast have longevity chemical responses, find another organisms, possibly even another yeast, that responds like yeast to a library of 10k different chemicals but has a 4 hour lifespan, also verify that when tested at the 4 hour lifespan 40-100 different
longevizing remain longevizing, then use that organism to screen new longevity chemicals in just 4800 minutes to 240 minutes each, so at the reacted sorted liposomes microfluidically connected to a 10 billion well yeast IC plate then after just 1/3 of a
day you would be able to know longevity had more than doubled, and based on well location, which chemicals were associated with the longevity heightening, and then make a completely new liposomal reaction 10 billion chemical library to screen on another
plate, that screens about 30 billion new longevity chemicals each 24 hours or 1 trillion new longevity chemicals a month



Are buckycup liposomes possible

That's like 1 nm or less buckycup like electron wave concentrating semiconductor manufacturing chemical or nano technological reaction/assembly, integrated circuit technology geometries technology



Noting 1 nanometer dots are likely possible with 3nm integrated circuit feature technology with a more casual error rate, then a 300 mm wafer has about 9 times 10^12 one nanometer features, a 1 nm diameter well 5000 nm deep (5 micrometers) is a stack
5000 molecules deep and one molecule wide (carbon 120 picometers, about 9 carbons to a well width) that could be sequentially piled up in the well to a depth and volume of 45,000 molecules, this makes me think of things like, load it up, use radiation to
initiate reaction or polymerization, or radiation to divide things like halogen atoms from their molecules to do new reactions, or load some areas with catalytic molecules like electrically addressable liquid crystal molecules with cobalt or Rh atoms on
it to do chemistry, may also be cycled between a temperature with 1/2 the reaction rate and one with the full reaction rate to load it when cool, light and charge based reactions are also cool,



One use for this is to screen libraries of high utility chem



Doped si features at sides of each well could make sides of well electronegative or electropositive or provide a surface with spin polarization particularity, or have light emitting diode sides to place full circumference illumination at each well

Noting that photoactivated physiochemicals exist and are published at 2019, there are likely many better ones but a 20 separate colors of photons simultaneously or cumulative together at 1 microsecond or more rapidly, light responsive protein could be
made, a 20 photon response accumulating version of polyrhodopsin could be made that changes the shape of the protein to a different shape with each amount of light energy, such as a photon, that is absorbed, the polyrhodopsin could be made to be white or
transparent and support the continued whiteness of skin, the photoreceptor proteins could be part of physiochemical activation systems and body effecting systems that photoactivate at the interior of mouth and GI tract or body surface as people prefer



Longevity technology



Electrical engineering technology



Architect technology

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I read human Eunuchs live 19 years longer than other people, plasma mass fractions and tissue homogenate chemicals from cow, horse, pig, or rat eunuchs as well as ordinary organisms could be compared to find chemical differences, then the different
chemicals administered to c elegans to find out if any had longevizing or modulating effects, also noting an old rat and a young rat with connected circulatory systems causes greater rat youthfulness (as well as possibly longevity, I do not remember
what it said) they could test eununch rats with their circulatory systems linked to ordinary rats of the same age to find out if there were longevity effects,



similarly there may be longevity chemicals sequential to the mTOR effects of rapamycin, published as making mice live 60% longer, connecting the circulatory systems of old rats that were, until 54 hours previously, on rapamycin, to those of old rats of
the same age could find out if there were non mTOR longevization chemicals circulating at the previously rapamycin treated rats



The difference between the human age equivalent of 60 year old normal rats and 60 year old multimonths of previous rapamycin, rapamycin treated rats could be characterized as to their electrophoretic physiochemical difference, and the notably different
chemicals tested on yeast and c elegans for longevity effects



The electrophoretic physiochemical difference between 30 and 40 year old human equivalent age rats and rapamycin treated 60 year old equivalent rats could be characterized, the most maintained physiochemicals from 30 year old to 60 year old rapamycin
treated rats (as compared to 60 year old untreated rats) these physiochemicals could be tested on yeast and c elegans, if large mammals on rapamycin are utilized then that could be a plentiful source of chemicals to test mice or shrews with









The difference (a list of only which are shared) between all the chemical differences between young and old test mammals, and eununch test mammals could create a more rapidly testable list of chemicals that heighten longevity



Electrical engineering technology

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Royal jelly is published as making mice live 25 (27%) longer, and queen bees live about 36 months, 12 to 24 times longer than other bees; noting that insect chemicals can cause mammals to live longer, it is possible other long lived insects could have
chemicals that cause greater longevity. The mice that were longevized with royal jelly were fed it orally, bringing up the possibility of change to the proteins in it; some insects, queen termites, live 50 years, with some possibility of 100 years,
feeding ground up insects to mice, both orally and as enteric capsule or coated material could find out if the ground up material of long lived insects cause greater longevity; another approach is to extract circulatory fluid (hemolymph) from these
insects and find out if it makes yeast or c elegans or fish live longer, notably, fish as vertebrates could be notably suggestive of mammalian activity; another insect to screen for longevity chemicals are cicada nymphs (17 years), beetles of the genus
Eleodes (up to 17 years)



longevity technology: I perceive I read playing back EEGs causes the brain to be better at learning and can reactivate emotions; it is possible that rather than EEG, electrical recordings from the surfaces of children and 16 year olds could be played
back at the body surface to find out if it has any longevizing, wellness, or healthspan effects; this could be tested on nude mice, and might go well with the body and tissue thickness of mice as proof of concept; at humans something like a wireless
recharging near body surface implant (kind of like a pacemaker) could provide the youthful EEG-like stimulus, notably it is possible that wave and frequency variants like nodal, antinodal or possibly depth-reaching electrical solitons https://phys.org/
news/2006-05-solitons-electronics.html (dissipative solitons, 100 times farther travel than regular solitons) could be used; notably, some current levels and alternate voltages for the EEG-like frequencies could be used to possibly reach tissues at
greater depth, as could wrist-to-wrist or leg to wrist, or even head to calf electrode placement



EEG playback technology: playing back EEGs to cause beneficial cognitive effects using different voltages or currents to reach deeper into tissue, notably though some currents and voltages might verge into tDCS (although AC-like) which is a different
thing; the previously described gelatin capsule sized piezoelectric frond hair adhering and head skin seeking technology could also do some tDCS as well as EEG recording, playback and software based synthesis; children’s EEGs could also be played back
at adults to find out if there were child-mind effects as well as, just possibly, longevising, wellness, or healthspan effects (seems unlikely, but is possible), notably children have more delta waves, and these occur during sleep, although less so at
older people, these child EEG frequencies could be played back while adults sleep; this could be tested on rats, or some larger animal like cows, sheep, or horses



Longevity technology: Some biologically occuring tings do rapamycin like things https://www.ncbi.nlm.nih.gov/pubmed/29165314 It is possible that mutating these plants, then screening their chemicals on yeast and things like c elegans with 96 well plate
technology could create much larger rapamycin like longevity chemicals at plants, these could then be genetically engineered into delicious as well as ubiquitous plant foods to create longevity producing fruits, grains, and food products like pasta,
pizza, potato products, breading, there is also the possibility that moving these gnes and gene products from plants to eggs and milk could be beneficial



a molecular variant or rapamycin, rapamycin preassociated (attached) to a protein makes it 2000 times more active, “To probe the affinities involved in the formation of the FKBP.rapamycin.FRB complex, we used fluorescence polarization, surface plasmon
resonance, and NMR spectroscopy. Analysis of the data shows that rapamycin binds to FRB with moderate affinity (K(d) = 26 +/- 0.8 microM). The FKBP12.rapamycin complex, however, binds to FRB 2000-fold more tightly (K(d) = 12 +/- 0.8 nM) than rapamycin
alone. No interaction between FKBP and FRB was detected in the absence of rapamycin. These studies suggest that rapamycin's ability to bind to FRB, and by extension to mTOR, in the absence of FKBP is of little consequence under physiological conditions.�
� It is possible some molecular version of rapamycin (a rapalog) could cause mTOR activity without FKBP protein, FKBP has immunoeffects so that molecule could have less immunoeffects than rapamycin



Rapamycin that is more water soluble, “clinical development of its formulations was hampered due to its poor solubility and undesirable distribution in vivo. Chemical modification of rapamycin presents an opportunity for overcoming the obstacles and
improving its therapeutic index. The objective of this study is to develop a drug-polymer conjugate to increase the solubility and cellular uptake of rapamycin.

METHODS:

We developed the rapamycin-polymer conjugate using a novel, linear, poly(ethylene glycol) (PEG) based multiblock copolymer. Cytotoxicity and cellular uptake of the rapamycin-polymer conjugate were evaluated in various cancer cells.

RESULTS:

The rapamycin-polymer conjugate provides enhanced solubility in water compared with free rapamycin and shows profound activity against a panel of human cancer cell lines. The rapamycin-polymer conjugate also presents high drug loading capacity (wt% ~ 26%)
when GlyGlyGly is used as a linker. Cellular uptake of the conjugate was confirmed by confocal microscopic examination of PC-3 cells that were cultured in the presence of FITC-labled polymer (FITC-polymer).

CONCLUSION:

This study suggests that the rapamycin-polymer conjugate is a novel anti-cancer agent that may provide an attractive strategy for treatment of a wide variety of tumors.” hydrophilic rapamycin combined with regular rapamycin could reach a wider variety
of tissue types, combined they could cause greater than the 60% longevity increase published at mice

Optically activated rapamycin, “We developed an optically activated rapamycin dimer” perhaps a topical benefit

focusing rapamycin effect on just one tissue (kidney), “Thus subcapsular delivery of rapamycin-loaded microspheres successfully inhibited local fibrotic response in UUO with less systemic effects. Therapeutic effect of released rapamycin was most
prominent in close vicinity to the implanted microspheres.”

longevity technology: Liver function genes, like SNPs, could be a source of new longevity drugs, gene therapy or also germline gene modification, “To identify the pathways that could be responsible for rapamycin's longevity effect, we analyzed the
transcriptome of liver from 25-month-old male and female mice fed rapamycin starting at 4 months of age. Few changes (<300 transcripts) were observed in transcriptome of rapamycin-fed males; however, a large number of transcripts (>4,500) changed
significantly in females. Using multidimensional scaling and heatmap analyses, the male mice fed rapamycin were found to segregate into two groups: one group that is almost identical to control males (Rapa-1) and a second group (Rapa-2) that shows a
change in gene expression (>4,000 transcripts) with more than 60% of the genes shared with female mice fed Rapa. Using ingenuity pathway analysis, 13 pathways were significantly altered in both Rapa-2 males and rapamycin-fed females with mitochondrial
function as the most significantly changed pathway. Our findings show that rapamycin has a major effect on the transcriptome and point to several pathways that would likely impact the longevity.” They could do this analysis at a variety of tissues,
including the gut, which I perceive I read secretes and might process a lot of physiochemicals

liposomes http://www.ijper.org/sites/default/files/IJPER_45_4_13.pdf

liposomes might or might not benefit rapamycin, a way to tell is if rapamycin has nootropic characteristics, possibly at a higher sample dose, and then see if a liposomal version causes more nootropic effect, notably though liposomes might cause longer
plasma half life and could possibly have different peak plasma concentrations so that might effect a nootropic effect

about 76% of some actual rapamycin liposomes get turned into liposomes, with the rest at the remaining fluid, that suggests drinking the extra fluid, or eating the trehalose it might be dried out on could provide another simultaneous, possibly different
tissue specific activity of rapamycin

depending on if phosphatidylcholine or phosphatidyl serine turns into, or is highly similar to phosphatidic acid liposomes made of these might be nonpreferred, suggesting a different liposomal production method “the efficacy of rapamycin is dependent
on the level of phosphatidic acid (PA), which is required for the assembly of both mTORC1 and mTORC2 complexes. Rapamycin interacts with mTOR in a manner that is competitive with PA. Therefore, elevated levels of PA, which is common in cancer cells,
increases the level of rapamycin needed to suppress both mTORC1 and mTORC2.”

liposome preservatives and how long liposomes last with refrigeration, “The use of cryoprotectants such as dextrose, sucrose, and trehalose may increase stability from hydrolysis. Also, samples may experience oxidation upon storage. The addition of
small amounts of antioxidants during processing may stabilize the suspension and limit oxidation of the product. SUV should be stored above their transition temperature for no longer than ~24 hours. LUV may be store for a longer period of time if stored
at 4-8°C when not in use. Hydrolysis of the lipid begins to occur immediately resulting in monoacyl derivatives (Lyso lipids) which act as detergents and disrupt the membrane, thus permeabilizing the membrane. After ~5-7 days at 4-8°C the internal
contents will begin to leak indicating hydrolytic degradation of the lipid. If membrane structure is not a critical parameter in your experiments, vesicles may be stored for 1-2 months with minimal (<10%) hydrolytic degradation.”

distilled water is likely a way to make liposomes be longer lasting, “or by binding metal ions that initially induced aggregation. However, the presence of aggregation can accelerate the process of coalescence of liposomes”

ions at a solution could cause liposomes to last less long, that suggests when making liposomes drug and lecithin, or purified phosphatidylcholine, amounts at something like ultrasonication to make the most liposomes per volume, it is also possible
filtering or centrifuging (?) liposomes could divide it from a fluid which might have uncombined, particularly oxidizable drug or phosphatidyl choline molecules

If there are longer versions of phosphatidylcholine they might make more durable liposomes, “Permeability and stability of liposomes are influenced by the rigidity/stiffness of the lipid bilayer.”

liposome size depends on how they are made, ultrasonication produced liposomes make “small unilamellar vesicles (SUV), 25 to 100 nm in size that consists of a single lipid bilayer.” shaking a liposome making solution with your arms makes “Large
unilamellar vesicles (LUV), 100 to 400 nm in size that consists of a single lipid bilayer. Multilamellar vesicles (MLV), 200 nm to several microns that consist of two or more concentric bilayers.” it is possible a combination of all three types reaches
a wider variety of tissues and likely has greater physiological activity and physiological availability than rapamycin at an enteric capsule

“liposomes prepared by using combinations of some lipids follows the order of physical stability form the correlation of the mean volume diameter, zeta potential and pH , egg lecithin (PC)/cholesterol (CH)/stearylamine (SA) < PC/CH/phosphatidylserine (
PS) < bovine brain ceramides (CM)/CH/palmitic acid (PA)/CS < PC/CH/cholesteryl sulphate (CS) at 4°C, as well as at 25°C, 2122after a 6-month storage period” also, “Vesicles composed of saturated phospholipids were found more stable compared to
phosphatidyl-choline(PC) liposomes”

Ethanol makes for better drug loading, “that rely on incubation temperatures above the phase transition temperature (Tc) of the bulk phospholipid to promote drug loading. In the absence of cholesterol, liposome permeability is enhanced at these
temperatures which, in turn, can result in the collapse of the pH gradient and/or unstable loading. Doxorubicin loading studies, for example, indicate that the drug could not be loaded efficiently into cholesterol-free DSPC liposomes. this problem could
be circumvented by the addition of ethanol as a permeabilityenhancer.Doxorubicinloadingratesincholesterol-free DSPC liposomes were 6.6-fold higher in the presence of ethanol. In addition, greater than 90% of the added doxorubicin was encapsulated within
2 h at 37 °C, an efficiency that was 2.3-fold greater than that observed in the absence of ethanol.” also, “Optimal ethanol concentrations ranged from 10% to 15% (v/v) and these concentrations did not significantly affect liposome size, retention.”

Dissolve in etoh first, then put the water in perhaps, perhaps some solvent that rapamycin is more soluble in than water could be put in the ultrasonic liposome maker at a 1 part per 100 amount to heighten colubility, another way is to see if the pile of
rapamycin dissolves whn you stir the liposome making fluid

Liposomes can be dried over sorbitol, “formulation of proliposomes lipid dried over a fine particulate, water soluble support like sodium chloride, sorbitol or polysaccharides imparts adequate physical and chemical stability and are ideally suitable
for lipophilic drugs” That might be functional with trehalose as well to absorb nonreacted fluids, while the trehalose might also preserve the liposomes

Trehalose as a liposome preservative, at lyophilized of liposomes, “aggregation of liposomes could be prevented by the formation of stable boundaries between the vesicles. The ability of cryoprotectants to form these stable boundaries has been
attributed to their ability to replace the bound water around the bilayer via interaction with the polar region of the lipid 36head group (water replacement hypothesis).” also, as to things like trehalose, “high concentrations (up to 30 mol.% in some
cases) are required” (to where it is gooey)

the trehalose, possibly, could be added to the fluid ahead of ultrasonication, “In the preferred embodiment, the liposomes are made in the presence of the combination of at least one sugar (sucrose, trehalose, lactose, maltose and glucose)”

liposomes could increase plasma half life of rapamycin availability

antioxidants as liposome preservatives, “use of antioxidants like α-tochopherols, betahydroxy toluene (BHT)”

Rapamycin is made from fungi, “Rapamycin and its analogs are clinically important macrolide compounds produced by Streptomyces hygroscopicus” so depending on how much rapamycin the fungi make those genes could be transferred to plants or perhaps
mammals like humans

Rapamycin might last awhile at the body, there are three plasma half lifes I have read, .9 hours, 9 hours, and 56 hours, one thing online says, “The long elimination half-life of sirolimus necessitates a loading dose but allows once daily
administration, which is more convenient”

Longevity technology: “Centenarians delay age-related methylation changes, and they can pass this methylation preservation ability on to their offspring.” suggests that drugs, or possibly some non-CRISPR CRISPR like thing could duplicate longevity
methylation at everybody

a-tocopherol looks kind of like phenylethylamine, perhaps putting a nitrogen on it, and maybe trimming away a couple CH3s that are on the long alkane distal to the cylic (bicyclic) part, as well as putting a halogen atom on it (I do not know if 2 grams,
at numerous doses of a-tocopherol is beneficial or nonbeneficial) so that just a few milligrams or even micrograms rather than 350 mg is a fun dose, also halogenation might outcompete a-tocopherol at some valuable body location, it could be a thing
though, a stimulant that is perhaps slightly beneficial

IGF1 (Insulin like growth factor) as well as insulin if modified, perhaps with gene therapy or germline genetic modification could produce IGF1 as well as insulin that do sugar response things while being neutral to longevity, perhaps causing less AMPK
activation (If that is what they do)

fetal environment as well as parental epigenetics are published as effecting longevity, methylation, ethylation and other epigenetic things could be modified with supplements or drugs during pregnancy to align the person the fetus becomes with highest
longevity, wellness, and healthspan; I do not know if more methylation during pregnancy is the thing, or if just specif areas of DNA methylation are the thing, different tissues, at the devloping fetus have different epigentics,

How much food the parents eat makes a difference in progeny wellness, “There is consistent evidence from both mice and rat models that modulating the maternal dietary status such as protein restriction during pregnancy can significantly affect
lifespan”, “F1 male mice exposed to maternal undernutrition during prenatal life produced F2 male offspring with impaired glucose tolerance and increased adiposity”, Also, at humans, “F2-generation offspring of women who were exposed to the
famine of 1944–1945 in the Netherlands (i.e., Dutch Hunger Winter) throughout the gestational period had 1.8 times more health problems in their adulthood than descendants of non-exposed women [70]. The offspring of the fathers, but not the mothers who
suffered from intrauterine undernutrition during the Dutch famine also had a significantly greater weight and body mass index in their adult life than the descendants of parents unexposed to the famine”, I perceive this suggests that at the fetus
different amounts of something like methylation (also acetylation, phosphorylation, methylation, phosphorylation, sumoylation, and ubiquitination) could effect longevity, which suggests drug localization of methyl donors could be beneficial, perhaps
optimal methylation of the CNS and heart could be a longevity area, “the epigenetic code changes dramatically during the embryonic development of the organism to initiate differential gene expression patterns between various developing tissues. This
code consists of chemical modifications of DNA and histone proteins that play a crucial role in packing the DNA by forming nucleosomes.” Acetylation promotes gene expression, perhaps rather than methylation acetylation of longevity genes could cause
greater longevity, also, “The dynamic “writing” and “erasing” of histone modifications are conducted by specific enzymes” suggesting that drugs that cause more beneficial enzymes to be produced, gene therapy as well as germline modification,
particularly with tissue localization of beneficial amounts of enzymes could be beneficial, this could be a longevity techology; what one paper describes as socioeconomic adversity “In sons and grandsons of men born outside wedlock, a 1.64- and 1.83-
fold excess risk of circulatory disease” Homesis also has an effect, so a drug or supplement that cause the right amount of stress, without the parents feeling the stress could be beneficial, “there is also evidence that exposure to mild stressors in
early development can result in beneficial (hormetic) effects and that adaptive modulation of epigenetic processes could significantly contribute to these effects [92–94]. There is also evidence that adaptive/hormetic effects can persist over several
generations”, as a longevity wellness drug, it is possible that parents could make their epigenetics (methylation, acetylation phosphorylation, others) like those of persons at the 99.999th percentile of longevity,

marmosets, a primate, could be used to measure the effect of epigenetics on longevity



finding longevity genes other than those that effect mTOR and AMPK: they could look at all the rodents (mice, beavers), and all the bats, and find the ones with the least and most favorable mTOR and AMPK genetics, then they could find the longest living
rodents and bats with the least beneficial mTOR and AMPK genetics, it is possible that noting 33 year rodent lifespan difference the long lived non beneficial mTOR and AMPK rodents can be compared with the lifespan of rodents with highly favorable mTOR
and AMPK genetics but lifespans of 1/2 to 1/4 or even 1/11 of that, then they can find the genes that cause the greater longevity even though mTOR and AMPK are least beneficial at the much longer lived rodents, also, they can just compare mice
genetically modified to have highly beneficial mTOR and AMPK with the genes of beavers to find the beaver non-mTOR and non-AMPK genes that cause the greater longevity even though the beavers might have median mTOR and AMPK genetics; they can do the same
thing with bats; The longevity drug benefit is that on finding the longevity genes of rodents that outlive rodents with optimal mTOR and AMPK genetics 4 to 11 times then the products of those genes, and the actual genes, can then be placed at mice to
find out if they are longevity drugs and genes, characterizing humans as to the amount of the new longevity genes activity and the amounts of their gene products, is also beneficial.

crispr rodent gene swap, find the longevity gene swapping beaver and mouse genes with CRISPR/cas9 to find out which non mTOR and AMPK genes cause mice to live much longer like the 35 year beavers

Longevity technology:

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finding human gene variants that predict responsiveness to different longevity drugs would be beneficial. Rapamycin and a rapalog each are published at 60% longevity increase, my perception is that that math functions describe a medianized response, so
noting half of all persons are above median, perhaps a greater than 60% rapamycin response could be predicted, and a gene therapy or a coadministered gene product upregulating drug might be able to cause a 99th percentile rapamycin response.

Squiggles developed with AI deep learning have been published that cause primate brains to produce more activity than views of faces and nature, it is possible that new squiggles developed with deep learning AI could cause greater amounts of response
than the beauty responding areas of the human brain, and that when humans view these squiggles people describe them as attractive, appealing, and beautiful. I am not aware of research on deep AI generated squiggles that are beauty experieince activating
above that of nature and human faces and form that are three dimesnional or that vary gradually. Among many beneficial uses of these squiggles could be decorating architecture, decorating energy producing utility plants (among them wind, photovoltaic,
nuclear, chemical), hairstyles, and notably anything with above median utility and during the year 2019 less than median aesthetic impression; trash dumpsters, parking facilities, some public transit, medical appliances, anything on a list of survey
generated “could look better” things at public and private spaces.

It is possible that things that are already aesthetically beneficial like plants, landscapes, nature, aesthetically appealing humans, could have versions and variations of deep AI developed beauty squiggles, and that actual spaces could be quantified as
to their beauty response as well as images duplicated. Also, automated mechanisms or also robots that clean and arrange dwelling spaces could arrange items that humans view and utilize to be simultaneously highly available and, with beauty squiggle
technology, arranged at ways that cause higher subjective well being increasing beauty response than the person doing their own arranging. People could of course do their own arranging, they might more often appreciate deep AI guided arrangeements of
things.

Aesthetically mild to beneficial things like computer interfaces and printed text, could generate a beauty response while being combined with other deep AI developed squiggles that simultaneously increase comprehension and retention to create beautiful
and cognitively enhanced interfaces and text; I favor a computer interface and text interface that causes heightened sense of well being (the psychometric: subjective well being increase from experiencing beauty), the “nice space” architecture effect,
the “startlingly gorgeous” art object response, and even the human reponse to human female beauty response at persons with any form of human sex chromosomes occuring at 98% or more of people;

There are no top of page results on a search of “chemical vapor deposition metallurgy” so these are some chemical vapor deposition metallurgy technologies. I read that 3 nanometer silicon features are produced at integrated circuit technology,
noting that arrays of atoms can have much more than an anisotropy or two at (25 atoms per feature, one to 20something billion features per IC, ) a trillion deposited atoms, that suggests that rather than a 3 nanometer feature size a 1 nanometer atom
group feature size could be produced, and that the dots could be customizably amorphous, crystalline, variations of crystalline or other forms.

rather than an integrated circuit phototemplate it is possible a UV laser could produce a regular array of dots or shapes at a photoresist with diffraction grating technology, switching between a few, or even a few hundred different atom location
preferentialization areas could produce a wide range of material characteristics;

thoughts on the size of chemical vapor deposition metallurgy part sizes: MEMs technology could also be a guide, with thickest chemical vapor deposition metallurgy being some higher of power of two than the 24 hour thickest MEMs object production cycle,
it could be higher, if manufacturing time equivalence is considered (a company orders parts for delivery every month, giving as much as 1 month photolithography growth or possibly MEMs thickness build up), if something like UV lasers with a diffraction
grating can be adapted to modify the shape of a growing single crystal of tungsten, like those used at some airplane turbines, then that could be a metallurgical chemical vapor deposition object size guide (although perhaps not, as I think they might
pull those out of a melt)

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a new kind of autophagy could be linked to longevity, healthspan, and wellness, if it is functional: Noting the idea that cytoplasm might have nonorganelle enzymes floating around, catalyzing things, possibly even comminuting or nonactivating some
cytochemicals: These enzymes, outside the lysosome remind me of autophagy, autophagy is linked to cytorefreshment, longevity, and wellness, it could be that the genetics of having more cytoplasm enzymes outside of organelles do something like an
alternate version of autophagy, refreshing and recycling physiostructures and chemicals, so looking at a variety of mammals, notably things like multicentury lifespan whales, beavers, naked mole rats, bats, tortoises, and parrots and 400 year lifespan or
longer clams, kings holly, and creosote (reminded of mitochondrial apoptosis) any cytoplasm enzymes, notably proteolytic or membraneolytic, outside of organelles (like lysosome) could be quantified at mice as to longevity wellness and healthspan effects,
and if beneficial made into gene therapy, drugs, or germline enhancement or optimization at humans;

Noting autophagy is linked to longevity, wellness and healthspan, and I might have read that AMPK heightens autophagy, it could be possible to engineer larger amounts of autophagy from 1) cytoterminating chemicals, proteins or peptides as drugs (possibly
kind of senolytic like), also as periodically automatically activated gene therapy; an accumulation of physiologically beneficial peptides, like AEDG heightening with each sleep occurence, could, when they accumulate to a particular amount, cause the
gene therapy modified tissue to produce a new circulating amount of the new autophagy chemical, causing fresh autophagy and renewal at the living human; these likely would benefit from localization to create beneficial differences in concentration and
action at different cytes and tissues;

Along with heightening cytoplasmic autophagy like effect enzymes, periodic production of autophagy as algorithmically activated with a completely beneficial physiochemical that accumulates (epithalon, thymosin, likely a variety of things, possibly even
beneficially heightened circulating omega 3 DHA from accumulation of DHA from endogenous production), there is also periodic, quantitatively measured as beneficial to longevity, wellness, and healthspan, triggering of mitochondria to zap cytes, causing
leukocytes to absorb them.

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Royal jelly is published as making mice live 25 (27%) longer, and queen bees live about 36 months, 12 to 24 times longer than other bees; noting that insect chemicals can cause mammals to live longer, it is possible other long lived insects could have
chemicals that cause greater longevity. The mice that were longevized with royal jelly were fed it orally, bringing up the possibility of change to the proteins in it; some insects, queen termites, live 50 years, with some possibility of 100 years,
feeding ground up insects to mice, both orally and as enteric capsule or coated material could find out if the ground up material of long lived insects cause greater longevity; another approach is to extract circulatory fluid (hemolymph) from these
insects and find out if it makes yeast or c elegans or fish live longer, notably, fish as vertebrates could be notably suggestive of mammalian activity; another insect to screen for longevity chemicals are cicada nymphs (17 years), beetles of the genus
Eleodes (up to 17 years)

longevity technology: I perceive I read playing back EEGs causes the brain to be better at learning and can reactivate emotions; it is possible that rather than EEG, electrical recordings from the surfaces of children and 16 year olds could be played
back at the body surface to find out if it has any longevizing, wellness, or healthspan effects; this could be tested on nude mice, and might go well with the body and tissue thickness of mice as proof of concept; at humans something like a wireless
recharging near body surface implant (kind of like a pacemaker) could provide the youthful EEG-like stimulus, notably it is possible that wave and frequency variants like nodal, antinodal or possibly depth-reaching electrical solitons https://phys.org/
news/2006-05-solitons-electronics.html (dissipative solitons, 100 times farther travel than regular solitons) could be used; notably, some current levels and alternate voltages for the EEG-like frequencies could be used to possibly reach tissues at
greater depth, as could wrist-to-wrist or leg to wrist, or even head to calf electrode placement

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