• Plausible mild antipsychotic, anti-OCD, preventer of social phobia

    From Treon Verdery@21:1/5 to All on Sun Sep 4 19:42:55 2022
    sertraline (zoloft) (about $44 for 30 days at 365-rx.com) might be antidepressant with some possible antipsychotic effects: Lometraline (INN; developmental code name CP-14,368) is a drug and an aminotetralin derivative.[1] A structural modification of
    tricyclic neuroleptics, lometraline was originally patented by Pfizer as an antipsychotic, tranquilizer, and antiparkinsonian agent.[2][3] However, it was instead later studied as a potential antidepressant and/or anxiolytic agent, though clinical
    studies revealed no psychoactivity at the doses used and further investigation was suspended.[1][4][5] Further experimental modifications of the chemical structure of lometraline resulted in the discovery of tametraline, a potent inhibitor of the
    reuptake of dopamine and norepinephrine, which in turn led to the discovery of the now widely popular antidepressant sertraline, a selective serotonin reuptake inhibitor (SSRI). “Over more than six months of sertraline therapy for depression, people
    showed a nonsignificant weight increase of 0.1%.[59] Similarly, a 30-month-long treatment with sertraline for OCD resulted in a mean weight gain of 1.5% (1 kg)”. Someplace online it says not to take it with an MAOI.

    Possible Recreational drug https://www.alibaba.com/trade/search?fsb=y&IndexArea=product_en&CatId=&SearchText=2-Aminotetralin $200 per kilogram
    wikipedia says about 2-Aminotetralin “2-Aminotetralin (2-AT), also known as 1,2,3,4-tetrahydronaphthalen-2-amine (THN), is a stimulant drug with a chemical structure consisting of a tetralin group combined with an amine.[1][2]
    2-AT is a rigid analogue of phenylisobutylamine and fully substitutes for d-amphetamine in rat discrimination tests, although at one eighth the potency.[“
    also, an entactogen “6,7-Methylenedioxy-2-aminotetralin (MDAT) is a drug developed in the 1990s by a team at Purdue University led by David E. Nichols.[1] It appears to act as a serotonin releasing agent based on rodent drug discrimination assays
    comparing it to MDMA, in which it fully substitutes for, and additionally lacks any kind of serotonergic neurotoxicity.[1] Hence, MDAT is considered likely to be a non-neurotoxic, putative entactogen in humans.”

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