• study looking at fruit flies, lutein prolonged the average lifespan of

    From Treon Verdery@21:1/5 to All on Sat Aug 13 22:22:49 2022
    A journal article mentions several DNA repair mechanisms, such as base excision repair (BER), nucleotide excision repair (NER), transcription-coupled repair (TCR), homologous recombination, nonhomologous end-joining (NHEJ), and telomere elongation, as a
    longevity technology an epigenetic RNA drug or other epigenetic that upregulates these mechanisms/proteins could be measured as to longevity increase in age batched groups of human volunteers, also, considering each DNA repair enzyme as part of a network
    there are possible network proteins and genes that reduce their amount or activity, knocking out those network repair decreaser genes or also epigenetically downregulating the decreasers can be measured as to possible longevity and tissue youthfulness
    effects at mice and marmosets

    Searching for an existing deleterious physiochemical cascade network then epigenetically downregulating it: repair diminishers, what if they have more than one function, more than one of which is deleterious, make an ordered list of largest number of
    deleterious actions of one gene/chemical for many genes and physiochemicals, so that genes that do a larger plurality of negative things each can be shortlisted, epigenetic downregulation of the production of those deleterious gene's physiochemicals
    would create one multiply beneficial longevity and wellness epigenetic drug; most things that build muscle are delongevizing so epigenetic hypermethylation of the top of the short list of body produced muscle building physiochemicals with the largest
    number of immediate or downstream sequelae is a new area of longevity drugs

    New epigenetic drugs that precisely locate on the acetylation-ome and methylome epigenetic maps and make their epigenetic changes effectively, RNA epigenetic drugs with high site specificity exist, i think, so synthetic ribonucleic acids that are
    nonmetabolized, so persist thousands of times longer, increased chemical ability to donate a methyl group or acetyl group, are possibly a nuclear membrane transport facilitating peptide linked to the synthetic nucleotide, overlay stencil, photonically
    activateable, dwell time from deuteration could increase giving longer moments for the methyl or acetyl group to attach, or at epigenetric drugs that remove a mark halogenated or Mg containing synthetic nucleotide sequences could glom away existing
    epigenetic marks from the halogen or metal giving the synthetic amino acid much greater charge concentration at useful places

    Lutein makes flies live 63% longer and concentrates in the occipital lobe which could be a great place to put nootropics and general simulants, an even higher level of visual instanteous memory and as wikipedia says, "ventral stream is known for
    processing the "what" in vision, while the dorsal stream handles the "where/how." This is because the ventral stream provides important information for the identification of stimuli that are stored in memory. With this information in memory, the dorsal
    stream is able to focus on motor actions in response to the outside stimuli." So as a nootropic phenylpiracetam molecularly linked to lutein would seek out just the particular area, the occipital lobe, that informs instant nonnarrative consciousness as
    well as narrative consciousness about what a thing is, that is a what a thing is in relation to entire life experience, this could be a valued drug for people, perhaps older people looking through a high school yearbook and recognizing a face 40% more is
    possible and fun

    Improving virtual reality with visual evoked potential measurement that finds greatest 3Dness and optimal brightness level, single electrode on a eeg head circlet measures visual evoked potentials and calibrates VR gear, such as with me the ratio of
    right and left proportions of viewing with polarized light shutter glasses

    Perky uplifted breast technology, ultrasound, photonic or MRI of the breasts make tissue composition and structure images, then CAD software redesigns that breast structure with very soft but elastic internal bands that pull up the breasts, once the CAD
    program designs the added ligament and connective tissue support-lines they can then be made part of the breasts with photonic drugs, do this with photonically active cell dedifferentiation, then a photonic drug that causes redifferentiation to gravity-
    unresponsive connective tissue or soft thin lines of ligament or connective tissue at the breasts, something like a galaxy shaped spiral could be made to tighten, and lift, the breast as the galaxy form is grown photonically, that is photonically growth
    hormone increase in the size of the galaxy looking new connective tissue form causes the many connected CAD soft ligament threads/lines to be pulled up as the galaxy grows and rotates from growth, from a photonically activated growth hormone, also
    simpler but different is photonically make a thin linear multiple CAD line support tissue stretched rubber band analog which pulls the breasts upwards from the linear band preferring a ~~~ undulating shape after it grows, as an experience it is as simple
    as going to the aesthetician topless, standing in front of a machine, having an inkjet printer print iontophoretic gel liners you put in a light emitting photonic bra, and then wearing the bra until the users breasts are perky as they would like them to
    be, also a person at her first D cup of breast growth under 14 could have her original naturally high and perky breasts ultrasound or photonically scanned, with another scan at 14, 16, 18 years of age, with a body and breast scan then recorded, this lets
    a woman reexperience and restore her teen body and have the high placement and perkiness of her breasts as a teen, its even possible the photonic drugs could just be oral pills and the breast reperkiness procedure is as simple as taking a pill a week and
    wearing the light emitting bra; teens at what a computer tells them is going to be their peak high placed perky large breasts can photonically install CAD diagram lines of superdurable connective tissue like ligament or the stuff spinal disks are made of
    to get over a century of internal perkiness support during that teen breast appearance and form high point, preserving it, the same scan and preserve technology can be used all over the body including the face, under upper arm area, stomach, thighs and
    buttocks

    Another way to do the photonically guided building of tissue that tightens to smaller than the area it grows at is to grow long lozenge shaped cells 3-5 times longer than wide, then dose them with chemicals shown at tissue culture studies to turn long
    cells into round ones, causing 3-5 times pull up on the photonically modified tissue, another application of this technology is to grow multiple tight annuluses at the interior of the vagina making what is described as a more highly pleasurable tight
    vagina, the annuluses could be placed as, and made connected to the vaginal canals A-spot and O-spot, as well as a third tight annulus positioned for greatest male person with penis pleasure, the anterior roof of the vagina and thrusting moved annuli can
    be photogenerated to have a full length of vaginal canal wedge phototissue in it and be connected with further connective tissue passes through and under the commisure to connect to the cliroris, a penis thrusting in a vagina could motionize the hills in
    the new photoproduced anterior vaginal wedge, when the hills, once per cm or inch are motionized the new connective tissue carries that all the way to the clitoris which feels rolling pushes when the penis goes in, and rolling pushes or base-shifting
    pulls when the penis pulls back before the next thrust, there could be four photonically grown undulating wedges, one for when the woman or teen is face up, one face down, and two different side-wedges, different wedges of tissue undulation patterns that
    rolling push the clitoris as many times as there are undulations in the wedge tissue, this beneficially provides clitoral stimulation from penis in vagina sex

    Neoteny reduces perception of risk, "stranger danger" from others, optimal to women rubbery feel of male, scalp, eyelash, eyebrow and20 pubic hairs as only hair at women and men, at males rectum and anus have 12 inch long raised wedge with undulations
    that connects to and push-moves prostate for greater pleasure during gay sex, or heterosexual sex with a woman wearing a strap-on, at the female version the photonically installed connective tissue can push-move the anal sphincter, traverse the gap to
    the vagina and push-move the clitoris, if there are male pheremones that are enjoyable to women then odorlessly increasing those 11 times is beneficial to women, and the same thing with female produced pheremones that men and bisexual women and lesbians
    enjoy, confident person genetics are popular at women as a male trait, and confident person genetics also benefit women to have, these are confident person genetics independent of genetic extroversion, there could be a genetics of being sexually
    attracted to children, just like there are homosexuality genes, who have not yet developed 10 pubic hairs, redirecting or turning off those genetics anti-sexual-towards-children attraction pill is epigenetic modifier taken whever a woman with children
    has her male lover overnight over 7 days, harmless to retake an epigenetic drug, another improvement of male men is to reinforce the body's existing anti-incest genetics possibly from making multiple copy numbers of the anti-incest genes (major
    histocompatibilty complex, high light triad personality, genes from comparing incest experiencing monozygotic twins with non incest twins, this beneficially decreases incest among male tweens and teens, another improvement to males is ectomorphic body
    type at both women and men, previously described are lighter stronger muscles such as tuna muscles, these make it so men can keep up fast deep sexual thrusting 30 times longer than they could without tuna muscles, 30 times strength and endurance also
    benefit women when having sex from the woman moving herself repeatedly on the penis, this also benefits cunnilingus and oral sex with a penis from greater tongue and throat and hand endurance, another improvement to men is to preclude male pattern
    baldness with genetic or epigenetic modifications that upregulate aromatase at the scalp and hair follicles, and downregulate aromatase inhibiors at scalp and hair follicles, dediferrentiation and redifferentiation to new hair follicles is also possible
    with oral pill and light exposure or iontophoretic scalp surface delivery, on the internet women express things they find attractive, beautiful, or sexy, one of these is testicles, so based on an image rating system where the male model has full front
    and side image presented with various sizes and pendancies of testicles, male testicular skin could be genetically engineered to feel more pleasure from very light touch and mouth licking and sucking of testicles, as well as larger size, up to current 99.
    9th percentile size, one woman on the internet mentions a sexual position where the testicles and testicular sac bounce against the upper external vagina and even clitoris, lengthening the pendulous testicular sac so that touch on the upper vagina occurs
    99% of the time in woman on all fours and man entering her vagina from behind position is a beneficial engancement to males,
    photonically clitoris and commisure wiggling from new photonically made connective tissue lines linear cells turn spherical with photonically activated drug

    MWI adjust gradient operator to have finite size, like a set of arrays, small arrays that edge coneect have simplest set of minimal arrays scroedingers equation functionalike can be built with, there may be a pluraly of different assemblages that replace
    the gradient operator the way 1*8 and 2*4 matrices it could be either one, think of experiments to test the multiple solutions and versions of the gradient operator, technologize what is found

    Electricity at a place of interment powers video game console, PC computer with programming languages, a terabyte of the most popular 400k images and animated gifs, and 3 monitor sized tablet pcs, sufficient photovoltaics atop the interment location to
    use two tablet pcs continuously 8 redundant wire connectors of ceramic coated stainless steel with Ptfe insulation to the interment areas, this can be superaffordable, 2021 photovoltaics are 70¢ a watt at alibaba and a high powered USB charger is 3W, so
    $6.30 of photovoltaics can keep 3 $40 new tablet pcs charged and on 24/7/365, a lit up tablet pc facing out away from the interred previously alive person with image to attract an elf, possibly favorite images of elves and Tolkien Elf language words, and
    lots of green with white or green with light brown then invite the elf to share a high light triad video game and offer to let them recharge with the complimentary electrcity, the person could be intered with 11 tablet pcs, and 11 two terabit microsd
    memory cards so they have plenty to give away

    Lutein makes drosophila live 63% longer so they should test it on mice for longevization, they could make versions of lutein that concentrate in different compartments and administer them to mice in different combinations to find the greatest
    longevization, omega-3 like lutein, have a novel angle on the WW at the same location as omega 3 fatty acids, lutein is one of 600 known carotenoids, do drosophila longevity studies on all of them at $740/ overseas study on 140 drosophila that are simply
    fed reconstituited chromotography starch paper micro cut outs to dose the drosophila with individuàl bands or paper hole punch outs added to their food, with 140 drosophila per culture tube its possible to connect two culture tubes with a wide passage
    and have the drosophila seek out the new tube based on gentle warming of it while the source tube is cooled, the food smells like a couple powers of two stronger at the warmed tube, doing that transfer once each 7 days provides lifespan longevity data
    points on the number of drosophila alive and the very meaningful longest lived 2%, this makes the study much cheaper, optimally 10 minutes of multiple nutrient plus 1 carotene tube making, perhaps with a 24 nozzle automated pipettors, then, transferring
    drosophila tube to tube is 2 minutes to connect the tubes each, and 2 minutes to image the nonliving drosophila in the previous tube, software counts the nonmoving drosophila in the previous tube, then that 4 minutes * 14 tube transfer events, with 11
    minutes to pour all the nutrient with individual tubes is 67 minutes per carotenoid *600 carotenoids, is 40200 minutes or 17 40 hour weeks, at a Chinese or Russian laboratory worker earning $10K a year that is $3400 of labworker time, drosophila media/
    food is cheap as it is potato starch with nonliving yeast, so $100, drosophila culture tubes are likely 2-9 cents each at alibaba, so 14 *600 culture tubes is 8400 * 6.n cents or $600, $200 for the plant and marine organism samples that contain the
    chomotographyizeable carotenoids, then add $100 for an overseas fiverr programmer who configures already existing speck counting at images software, the total amount is $4400 to produce a longevity effects of 600 different carotenoids, data table or
    database, which can be published as a 2-3 page long table at a scientific journal, such a data table could be used to make combination carotenoids at the 99th percentile as longevity supplements, and the database could be used to find structure to
    longevity function trends, supporting the creation of new carotenoid longevity drugs that are even more longevizing at mice

    If lutein or also 99th percentile of longevization of 600 known carotenoids are halogenated or ethynylized their longevity effects could increase, and at fluorination have 100-1000 times higher dose potency, that heightened dose potency could make an
    airjectable depot drug with two centuries of activity from 7-8 separate 1 gram airjections between the shoulder blades or at the thigh all at once, if age batched volunteers show human longevity increase then synthetic genes that manufacture those
    carotenoids at the human body interior, omitting dermis, to maintain white dermis is a new human longevity gene beneficial to put at the human (Homo sapiens and branch species) germline genome

    Based on molecules like Skq1 and PQQ the polyphosphonium moiety causes transport into the mitochondria, attaching polyphosphonium to NMN or NAD with an enzymatically degradeable linker causes NMN or also NAD to reach the mitochondria preferentially
    strongly increasing dose potency, which makes these longevity or also wellness drugs 10 or 100 times more affordable

    Genes of hypomania, restating hypomania as energetic and happy, monozygotic twins find unipolar hypomania genes

    Noting young and fetal tissue advantages, baby plant leaves, blenderized cotyledons could have wellness longevity effects, test the effects of feeding 40 different species cotyledons to 96 well plate fish or c elegans to see if any of them are longevizing

    New immunization technology that makes a tissue penetrating vaccine feel like a delicious flavor oral vaccine, noting pop rocks, an explosive candy, put a wad of poprocks in the mouth between cheek and gum, and tune the explosive power to be more intense
    such that it drives pointy microcrystals that contain vaccine 1-2 mm into the cheek and gum tissue, this is reminiscent of the existing vaccine soaked transdermal sugar spikes patch vaccine technology but with the added penetration ability of customized
    pop rocks microexplosions, this could also be a fun new tasty way to administer recreational peptide and protein drugs that is less fuss than snorting
    Quantum camera quantum entangled spectroscopy likely already exists

    Modify flash memory to 1000 times faster
    Zeptosecond lasers energize photoelectric effect at base of flash memory cell to write data
    New Scientist quantum camera article describes a quantum camera featuring imaging a figurine without a photon return path, use that quantum camera to do spectroscopy of each flash cell to determine if it is full of electrons, to do that it could use a
    nanodab of fluid, like ammonia, that electrons dissolve in, when electrons dissolve in ammonia i think the ammonia undergoes spectroscopic shift, detectable to a zeptosecond laser spectroscopy quantum camera(SQC), the SQC does 3 one zeptosecond data
    reads per flash cell so best 2 out of 3 error reduction of a better error reduction system is used, the SQC has a plurality of amplified signal wires coming from it that brings the data to the CPU or AI processing unit, a way to make plural zeptosecond
    lasers, say 10 billion of them is to have one high powered zeptosecond laser and use retroreflection at a beamsplitter and very slightly angled mirror to make a vast plurality of beamlets, if at optics lab on a chip one million separate ZHz lasers can
    each split into one million beamsplitted laser beams then that is a trillion flash memory cells that can be read simultaneously, providing instant,1-3 zeptoHz full scanning of the contents of the flash drive, the ammonia that dissolves electrons could
    possibly be replaced with an ammoniated fluorocarbon or electrolytic capacitor fluid

    As a playground and play equipment child-child interaction fosterer a tall lightpost could draw little shapes in light on the playground equipment, some children might be attracted to a particular part if it were lit up with green arrows or miniprojector
    moving patterns like an image of rounded moving white moire, a green leafy tree, a nyan cat like unicorn, an image of the face of a child, or hearts, they would measure the effects of light decoration on play duration and child happiness to continually
    improve the lightforms made to appear on the playground equipment, alibaba $ is near $60 for an aluminum streetlight pole, and a high lumen pc projector is $38-100, the projectors are phone compatible so programming might be as easy as playing a 48 hour
    video loop

    I read on the internet that prestressed wood, like prestressed concreate has metal shapes running through or around it, mid 20th century tests of prestressed wood found is was 31 to 50% stronger, now with laser grooving of wood the wires can be flush
    with the surface, and alternatives like sawable polymers, even recycled polymers tensioning elements can be placed in these lasered grooves to provide opposite tension to a predicted load, also now genetic algorithms could optimize simultaneous
    affordability and strength of prestressed wood, if genetic algorithms can bring that number to 65% stronger wood then an equally strong house can be made with only a fraction of the tree products, benefitting houses becoming more affordable worldwide,
    other alternatives to lasering out a channel and filling it with polymer are centipede staples -]-]-] that share a center bar and are stapled into the wood at the factory, note centipede staples can be made of polymer for easy sawability







    Genetic algorithms improve chinese finger puzzles when they are used as compression surrounds on prestressed concrete

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