Gut bacteria may play vital role in Crohn’s disease
Meghan Rosen | May 10, 2016 | Science News


The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion and analysis.

Good gut bacteria might not help people with Crohn’s disease.

Protective microbial messages go unread in mice and in human immune cells with certain defective genes, researchers report in Science.

The findings are the first to tie together the roles of genes and beneficial microbes in the inflammatory bowel disease, says biologist Brett Finlay of the University of British Columbia in Vancouver, who was not involved in the new work.

“This is a major step forward in this area,” he says. Human genes and friendly microbes work together to control inflammation, he says. “And when you muck that up, things can go awry.”

In Crohn’s disease, the immune system riles up too easily, trigging chronic inflammation. Scientists don’t know why exactly people’s immune systems go haywire. But researchers have linked the disease to glitches in nearly 200 genes, including
ATG16L1 and NOD2, which typically help kill bad bacteria in the gut.

Researchers have also reported that people with Crohn’s have a different collection of gut microbes compared with that of healthy people, says study coauthor and Caltech microbiologist Sarkis Mazmanian. But though “there’s a huge body of literature
on the genome and on the microbiome,” he says, “no one knew what the interplay was between the two.”

Read full, original post: Some Crohn’s genes make cells deaf to messages from good gut bacteria

Related
Designer gut bacteria could help fight stomach diseases in the future Biologists at the Massachusetts Institute of Technology have created a genetically modified version of a common bacteria found in the gut that can sense the environment there and fight disease. And when this designer bacteria works, the proof is in the
poop — glowing poop. (In this case, mouse poop.)…
In "Bio Drugs"
Immune therapy for cancer needs the right gut stuff
Immune therapy for cancer needs the right gut stuff
In "Bio Drugs"
Gene therapy used to combat immunodeficiency
UCLA researchers are using a gene therapy to restore the immune systems of children with so-called "Bubble Boy" disease. The Ainslie family has been dealing with a rare disease since their son was born. Mom Jessica Ainslie says, "He started getting
really bad cough, vomiting, and throwing up."
In "Biotechnology"
Previous Post
Not All Processed Food Is Unhealthy
Next Post
Mary-Dell Chilton, Developer Of First Transgenic Plant, On Future Of GMOs




https://www.geneticliteracyproject.org/2016/05/10/gut-bacteria-may-play-vital-role-crohns-disease/

--- SoupGate-Win32 v1.05
* Origin: fsxNet Usenet Gateway (21:1/5)