Long-Chain Polyunsaturated Fatty Acids Supplementation and Respiratory Infections
Valentina De Cosmi cs 2022
Ann.Nutr.Metab.10:1-8 doi 10.1159/000522093

LC-PUFAs can actively affect the maintenance & optimal functioning of immune cells.
Omega-3 & omega-6 metabolites play an important role in the synthesis of different mediators (prostaglandins, leukotrienes, thromboxanes, protectins, resolvins) that can interfere with the virus & modulate inflammation.

In this narrative review, we aim to identify:
is LC-PUFA supplementation effective in protecting the population against respiratory tract infections?
We included only randomized controlled trials, performed in both pediatric & adult subjects.
8 papers were selected: 5 trials in a pediatric population, 3 in adults.

Different concentrations of FAs supplementation were ass.x a lower incidence of common respiratory symptoms,
2 studies did not provide significant results.
Most of the studies are of low quality, and respiratory infections were assessed as secondary or even safety outcomes.

Key messages:
No data were available on the role of LC-PUFAs in COVID-19.
These data showed that LC-PUFAs may be effective in preventing respiratory tract infections,
but future studies are still needed, to clarify their possible co-adjuvant role in the prevention & treatment of respiratory infections.

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