What is Ozempic?

Ozempic (semaglutide) is a once-weekly injection that is FDA approved for use by adults with type 2 diabetes to control their blood sugar levels. Ozempic is also used by adults with type 2 diabetes who have heart and blood vessel disease to reduce their
risk of a stroke, heart attack, or death. The active ingredient (semaglutide) in Ozempic has also been shown in clinical trials to be useful for weight loss, however Ozempic is currently not an FDA approved weight loss drug.

Ozempic is used when other medications have been tried but have not controlled the sugar levels well enough. It should be used along with a diet and exercise program.

Type 2 Diabetes is a long term condition when your blood sugars become too high as the body does not produce or use insulin normally. If you have high blood sugars over a period of time it can cause serious health problems including heart disease, stroke,
kidney problems, nerve damage, and eye problems

Ozempic works to lower blood sugar levels by helping the pancreas to release the right amount of insulin when blood sugar levels are high, which moves sugar from the blood into other body tissues where it is used for energy. Ozempic injection also works
by slowing the movement of food through the stomach and may decrease appetite and cause weight loss.

Ozempic injection is from a class of medications called incretin mimetics. Ozempic acts as a glucagon-like peptide (GLP-1) receptor agonist that selectively binds to and activates the GLP-1 receptor, the target for native GLP-1. GLP-1 is a hormone that
has multiple effects on glucose, mediated by the GLP-1 receptors.

This medicine is not used to treat type 1 diabetes or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated). Ozempic is not used to replace insulin to treat people with diabetes who need insulin.

Is Ozempic used for weight loss?

Ozempic contains the active ingredient semaglutide, which is FDA approved for weight loss under the brand name Wegovy, but the Ozempic brand of semaglutide is not FDA approved for weight loss.

Ozempic contains the same active ingredient (semaglutide) as:

Wegovy injections which are used weekly for weight loss in adults who have obesity, or are overweight (excess weight) and also have weight-related medical problems.
Rybelsus tablets which are taken daily to lower blood sugar levels for type 2 diabetic patients along with diet and exercise.
Important Information

Ozempic injection may increase the risk that you will develop tumors of the thyroid gland, including medullary thyroid carcinoma (MTC) which is a type of thyroid cancer. Laboratory animals who were given semaglutide developed tumors, but it is not known
if this medication increases the risk of tumors in humans.

Tell your doctor if you or anyone in your family has or has ever had MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) which is a condition that causes tumors in more than one gland in the body. If so, your doctor will probably tell you not to
use this medicine. If you experience any of the following symptoms, call your doctor immediately: a lump or swelling in the neck; hoarseness; difficulty swallowing; or shortness of breath.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body’s response to this medicine.

Your doctor or pharmacist will give you the manufacturer’s patient information sheet when you begin treatment and each time you refill your prescription. The medication Guide is available on this link Medication Guide Read the information carefully
and ask your doctor or pharmacist if you have any questions. Talk to your doctor about the risks of using this medicine.

Before using Ozempic
Tell your doctor and pharmacist f you are allergic to semaglutide, albiglutide (Tanzeum; no longer available in the US), dulaglutide (Trulicity), exenatide (Bydureon, Byetta), liraglutide (Saxenda, Victoza), lixisenatide (Adlyxin, one of the active
ingredients in Soliqua), any other medications, or any of the ingredients in Ozempic injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
Tell your doctor if you have or have ever had pancreatitis (inflammation of the pancreas), diabetic retinopathy (damage to the eyes caused by diabetes), gallbladder disease, or kidney disease. Also tell your doctor if you have recently had diarrhea,
nausea, or vomiting or if you cannot drink liquids by mouth, which may cause dehydration (loss of a large amount of body fluids).
If you plan to become pregnant. Your doctor may tell you to stop using Ozempic for 2 months before a planned pregnancy.
Tell your doctor if you are pregnant or are breastfeeding. If you become pregnant while using this medicine, call your doctor.
Ask your doctor what to do if there is a large change in your diet, exercise, or weight; or if you get sick, develop an infection or fever, experience unusual stress, or are injured. These changes and conditions can affect your blood sugar and the amount
of this medicine you may need.
You should know that your mental health may change in unexpected ways and you may become suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are using semaglutide injection for weight loss. You, your family, or
your caregiver should call your doctor right away if you experience any of the following symptoms: depression; talking or thinking about wanting to hurt yourself or end your life; withdrawing from friends and family; preoccupation with death and dying;
or any other unusual changes in behavior or mood. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.
How should I use Ozempic?

Ozempic comes as a solution (liquid) in a prefilled dosing pen to inject subcutaneously (under the skin). It is usually injected once a week without regard to meals, on the same day each week at any time of day. You may change the day of the week that
you use semaglutide as long as it has been 2 or more days (48 or more hours) since you used your last dose.

Your doctor will probably start you on a low dose of Ozempic and increase your dose after 4 weeks. Your doctor may increase your dose again after another 4 weeks based on your body’s response to the medication.

Ozempic can be injected into your upper arm, thigh, or stomach area. Change (rotate) the injection site with each injection. You can inject Ozempic and insulin in the same body area, but you should not give the injections right next to each other. Allow
the pen to warm to room temperature before injecting if the pen was stored in the refrigerator.

Always look at the solution before you inject it. It should be clear, colorless, and free of particles. Do not use this medicine if it is colored, cloudy, thickened, or contains solid particles, or if the expiration date on the bottle has passed.

Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use this medicine exactly as directed. Do not use more or less of it or use it more often than prescribed by your
doctor.

Carefully read the manufacturer’s instructions for use that comes with the medication. These instructions describe how to inject a dose Ozempic . Be sure to ask your pharmacist or doctor if you have any questions about how to inject this medication.

This medicine helps to control blood sugar levels, but it is not a cure. Continue to use this medicine even if you feel well. Do not stop using this medicine without talking to your doctor.

Never reuse needles and never share needles or pens. Always remove the needle right after you inject your dose. Dispose of needles in a puncture-resistant container. Ask your doctor or pharmacist how to dispose of the puncture resistant container.

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