See if you can follow this:
Immune responses at the respiratory mucosal interface are critical to
prevent respiratory infections but it is unclear to what extent
antigen specific mucosal secretory IgA (SIgA) antibodies are induced
by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with and without prior coronavirus disease 2019 (COVID-19) at multiple time points pre and post severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Our
results suggest mucosal SIgA responses induced by mRNA vaccination are impacted by pre-existing immunity. Indeed, vaccination induced a
minimal mucosal SIgA response in individuals without pre-exposure to SARS-CoV-2 while SIgA induction after vaccination was more efficient
in patients with a history of COVID-19.
https://www.nature.com/articles/s41467-022-32389-8
kmiller wrote:
See if you can follow this:I must not be following that - it seems to say that I should have tried
Immune responses at the respiratory mucosal interface are critical to
prevent respiratory infections but it is unclear to what extent
antigen specific mucosal secretory IgA (SIgA) antibodies are induced
by mRNA vaccination in humans. Here we analyze paired serum and saliva
samples from patients with and without prior coronavirus disease 2019
(COVID-19) at multiple time points pre and post severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Our
results suggest mucosal SIgA responses induced by mRNA vaccination are
impacted by pre-existing immunity. Indeed, vaccination induced a
minimal mucosal SIgA response in individuals without pre-exposure to
SARS-CoV-2 while SIgA induction after vaccination was more efficient
in patients with a history of COVID-19.
https://www.nature.com/articles/s41467-022-32389-8
to get covid before I got vaxxed in order for the vax to have maximum efficaciousness. If that's what it says, at the end of the day going
forward I'm literally SOL, because the passage of time is significant
and I don't know how to pivot and reorient into the past for a do-over.
I literally put all the tools in my toolbox on the table, did two
careful inventories, and there's no mulligan wrench there. Do you think
I could get one at Harbor Freight? Or as a last resort, could I use a
monkey wrench off-label?
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