• Re: 'Forever' chemicals in cookware linked to liver cancer in first hum

    From Fried Cancer@21:1/5 to All on Thu Aug 11 07:23:20 2022
    XPost: talk.politics.guns, sci.chem, alt.food.safety
    XPost: alt.fan.rush-limbaugh

    In article <t2fsh6$3jeoj$152@news.freedyn.de>
    <governor.swill@gmail.com> wrote:

    There’s growing evidence that regular exposure to man-made
    “forever” chemicals, which are used in a variety of household
    products, are linked to rising cancer rates.

    A new study that examined the correlation between liver cancer
    and the presence of these chemicals in humans found that people
    with the highest levels of exposure have 350% greater odds of
    eventually developing the disease.

    The term “forever” chemicals refers to the more than 4,700
    available types of perfluoroalkyl and polyfluoroalkyl
    substances, or PFAS, used widely across manufacturing industries
    — named as such because the substances degrade very slowly and
    build up over time, in soil, drinking water and in the body.

    PFAS were first introduced in the 1930s as a revolutionary
    material used in the creation of nonstick cookware — hello,
    Teflon — and soon adapted to all sorts of products and packaging
    — from construction materials to cosmetics — that benefit from
    its liquid- and fire-resistant properties, as noted by the
    Centers for Disease Control and Prevention.

    Though incredibly useful, such chemicals have since been linked
    to the onset of cancer and other illnesses in lab animals.
    Following strong anecdotal evidence that perfluorooctanesulfonic
    acids (PFOS) alongside another common substance called
    perfluorooctanoic acid (PFOA) were making consumers sick, the
    Environmental Protection Agency in 2006 ordered eight
    multinational manufacturing corporations represented in the US
    to phase out the use of such chemicals. Nevertheless, as their
    nickname implies, PFOS and PFOA are still being detected in
    foreign products, in groundwater and in people.

    The current study, published in JHEP Reports, is the first to
    show a clear association between any PFAS and nonviral
    hepatocellular carcinoma (the most common type of liver cancer)
    in humans, too.

    “This builds on the existing research, but takes it one step
    further,” said Jesse Goodrich, a postdoctoral public health
    researcher at Keck School of Medicine, in a University of
    Southern California news release. “Liver cancer is one of the
    most serious endpoints in liver disease and this is the first
    study in humans to show that PFAS are associated with this

    Showing an association between PFAS and cancer in humans hasn’t
    been easy for scientists.

    “Part of the reason there has been few human studies is because
    you need the right samples,” added Keck School of Medicine
    professor Veronica Wendy Setiawan. “When you are looking at an
    environmental exposure, you need samples from well before a
    diagnosis because it takes time for cancer to develop.”

    To make this leap, researchers were given access to the
    Multiethnic Cohort Study database, which entails a survey of
    cancer development in more than 200,000 residents of Hawaii as
    well as Los Angeles, Calif., conducted by the University of

    Their search was narrowed to 100 survey participants — 50 of
    them with liver cancer and 50 without — whose available blood
    and tissue samples were sufficient for analysis. Researchers
    were looking for traces of “forever” chemicals present in the
    body before the group with cancer became ill.

    They reportedly found several types of PFAS among participants,
    with PFOS appearing most prominently among those in the group
    with liver cancer. Indeed, their investigation revealed that
    those who fell in the top 10% of PFOS exposure were 4.5 times
    more likely to develop hepatocellular carcinoma when compared to
    those with the least exposure.

    The clear link between PFAS and cancer in humans is crucial to
    further study on how these chemicals interfere with biological
    processes. Per the current findings, USC scientists now believe
    that high concentrations of PFOS in some subjects had impaired
    the liver’s ability to metabolize glucose, bile acid and
    branched-chain amino acids, resulting in unhealthy levels of fat
    accumulation in the organ, otherwise known as nonalcoholic fatty
    liver disease — a high-risk factor for liver cancer.

    That’s why many scientists agree it’s no coincidence that the
    advent and widespread use of “forever” chemicals correlates with
    a rise in liver disease, cancer and other illnesses.

    “We believe our work is providing important insights into the
    long-term health effects that these chemicals have on human
    health, especially with respect to how they can damage normal
    liver function,” said study author Dr. Leda Chatzi. “This study
    fills an important gap in our understanding of the true
    consequences of exposure to these chemicals.”

    https://nypost.com/2022/08/09/forever-chemicals-linked-to-liver- cancer-in-first-human-study/

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