A discovery in the muscles of long COVID patients may explain exercise
troubles

Hit the gym. Get back in shape.

That's what many patients with long COVID are told when they talk of
the crushing fatigue that envelops them after even a light bout of
physical activity.

These symptoms of exhaustion, or post-exertional malaise as it's
called, are a hallmark of long COVID and similar complex illnesses
like chronic fatigue syndrome or ME/CFS.
...
...
By taking biopsies from long COVID patients before and after
exercising, scientists in the Netherlands constructed a startling
picture of widespread abnormalities in muscle tissue that may explain
this severe reaction to physical activity.

Among the most striking findings were clear signs that the cellular
power plants, the mitochondria, are compromised and the tissue starved
for energy.

"We saw this immediately and it's very profound," says Braeden
Charlton, one of the study's authors at Vrije University in Amsterdam.

The tissue samples from long COVID patients also revealed severe
muscle damage, a disturbed immune response, and a buildup of
microclots.

"This is a very real disease," says Charlton. "We see this at
basically every parameter that we measure."


https://www.npr.org/sections/health-shots/2024/01/09/1223077307/long-covid-exercise-post-exertional-malaise-mitochondria

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On 2024-01-09, JAB <here@is.invalid> wrote:

Among the most striking findings were clear signs that the cellular
power plants, the mitochondria, are compromised and the tissue starved
for energy.
"We saw this immediately and it's very profound," says Braeden
Charlton, one of the study's authors at Vrije University in Amsterdam.
The tissue samples from long COVID patients also revealed severe
muscle damage, a disturbed immune response, and a buildup of
microclots.
"This is a very real disease," says Charlton. "We see this at
basically every parameter that we measure."

Each virus gets a little better designed to exploit our weaknesses.
Sounds like this one is able to really mess us up! And it's evolving of course, and far faster than we are.

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On Tue, 09 Jan 2024 23:09:12 GMT, Retrograde
<fungus@amongus.com.invalid> wrote:

Sounds like this one is able to really mess us up!

"My body, my choice," they say, until it hits them.

There might be a genetic relationship for affected persons.

a disturbed immune response, and a buildup of
microclots.

"Estimates show that more than 65 million worldwide have the
condition, which encompasses a wide range of symptoms that are
worsened or appear after initial SARS-CoV-2 infection. But three years
after the first people with persistent symptoms were documented, there
is no biomarker for the disease -- no test or swab that can diagnose
someone with Long COVID."

https://www.unmc.edu/healthsecurity/transmission/2023/05/16/long-covid-scientists-try-to-unravel-blood-clot-mystery/

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On 2024-01-09, JAB <here@is.invalid> wrote:

On Tue, 09 Jan 2024 23:09:12 GMT, Retrograde
<fungus@amongus.com.invalid> wrote:

Sounds like this one is able to really mess us up!

"My body, my choice," they say, until it hits them.

I'm fine with this. They've made their choice, they can live with it
(or die with it). 8 Billion angry hairless pink monkeys on this earth,
a few less won't matter.

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On Wed, 10 Jan 2024 02:42:12 GMT, Retrograde
<fungus@amongus.com.invalid> wrote:

"My body, my choice," they say, until it hits them.

I'm fine with this.

I suspect those 65 million+ worldwide will have a shorter life span,
which in another way, might be environmentally better.

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