• OT: Just the two of us...

    From AntiPro&T1.1DM@21:1/5 to All on Thu Jul 8 21:56:32 2021
    Time to remind Danny that only 1 person on Earth scans (not reads) his posts.

    Me. So he spins his wheels going nowhere fast. Oh well, what can he do?
    --
    APT1.1DM = SAID+T5 = SAID+(MARD/50) = T1.1, per Lancet 5 DM Groups.
    Insulinitis = Insulitis: â-cell destruction by lymphocytes, not a disease name. Islit, cellosis and diminosis are nonsense words used by 1 crazy person on Earth.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Alan Mackenzie@21:1/5 to HELP_Pro!@everyday.thx on Fri Jul 9 10:49:05 2021
    AntiPro&T1.1DM <HELP_Pro!@everyday.thx> wrote:
    Time to remind Danny that only 1 person on Earth scans (not reads) his
    posts.

    Me. So he spins his wheels going nowhere fast. Oh well, what can he do?

    Actually, I still read your posts. I avoid Danny's posts, most of them,
    due to their prolixity, and the fact that they are usually highly
    offensive.

    --
    APT1.1DM = SAID+T5 = SAID+(MARD/50) = T1.1, per Lancet 5 DM Groups. Insulinitis = Insulitis: β-cell destruction by lymphocytes, not a
    disease name. Islit, cellosis and diminosis are nonsense words used
    by 1 crazy person on Earth.

    --
    Alan Mackenzie (Nuremberg, Germany).

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From AntiPro&T1.1DM@21:1/5 to Alan Mackenzie on Fri Jul 9 14:10:50 2021
    Alan Mackenzie wrote:

    Me. So he spins his wheels going nowhere fast. Oh well, what can he do?

    Actually, I still read your posts. I avoid Danny's posts, most of them,
    due to their prolixity, and the fact that they are usually highly
    offensive

    OK! Then just the three of us!

    So how is your new insulin therapy working out? What changes have you
    been forced into after porcine insulin was removed? How long before your
    body adjusted, stabilized to the change?

    My insulin therapy has been very stable after not using Humalog (Lispro).
    I've found my body has been changing as I age as well. More insuln resistance as I get older it seems. So I need to slow down the fast Novolog in the morning
    to produce a flat BG in the afternoon when I fast (no lunch). I do this by mixing with the old rDNA human Novolin Regular. Today fasting BG was 95mg/dl and I dosed 3U Novolog mixed with 7U human Regular in 1 bolus. Test in progress
    to see if BG rises or lowers at 3 hours. But also have a slight hangover from 700mL Italian Grande Red last night. So insulin resistance is lower than usual this morning. Removed 2U for the booze effect. Will see.

    My Doctor retired this year, so will see a new Doc in September. Both are in the same practice so records are shared.

    Have not been posting much about COVID-19. But have been watching the local infection data that is rising from 4% to 6% positive rate for the last 2 weeks. The Delta variant from India is kicking ass here. So have started to mask-up again. The Lambda variant from Peru is also on the radar. So back to a semi- isolation as the new data rolls in.

    My last A1c was 6.5% so working to get it at 6% for September Doc appt.
    Current calculated A1c is 6.1% with a new math model under test. New model
    has an exponential decay after 30 days of uniform RBC cohort lifespan. 50%
    of A1c in last 30 days and 50% in 31-120 days set the exp rate constant for
    the RBC daily cohort weighted average. Removed very low A1c values in
    curve fit data as alpha lipoic acid bad data (too low, not believed).

    So long-term A1c experiment in progress too. (Elsa left no damage either.)
    --
    APT1.1DM = SAID+T5 = SAID+(MARD/50) = T1.1, per Lancet 5 DM Groups.
    Insulinitis = Insulitis: â-cell destruction by lymphocytes, not a disease name. Islit, cellosis and diminosis are nonsense words used by 1 crazy person on Earth.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From AntiPro&T1.1DM@21:1/5 to All on Fri Jul 9 16:30:37 2021
    AntiPro&T1.1DM wrote:

    Today fasting BG was 95mg/dl
    and I dosed 3U Novolog mixed with 7U human Regular in 1 bolus. Test in progress
    to see if BG rises or lowers at 3 hours. But also have a slight hangover from
    700mL Italian Grande Red last night. So insulin resistance is lower than usual
    this morning. Removed 2U for the booze effect.

    BG at 3 hours was 82mg/dl. The computer model for the 3U/7U mixture has an insulin action (glucose disposal peak) at 1.55 hours. So BG will stay flat from
    here. Going into lunch now with liver enzymes set up for BG homeostasis.

    The mixture has a fast tail so no hypoglycemia.
    --
    APT1.1DM = SAID+T5 = SAID+(MARD/50) = T1.1, per Lancet 5 DM Groups.
    Insulinitis = Insulitis: â-cell destruction by lymphocytes, not a disease name. Islit, cellosis and diminosis are nonsense words used by 1 crazy person on Earth.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From AntiPro&T1.1DM@21:1/5 to All on Fri Jul 9 21:30:57 2021
    AntiPro&T1.1DM wrote:

    Have not been posting much about COVID-19. But have been watching the local infection data that is rising from 4% to 6% positive rate for the last 2 weeks.
    The Delta variant from India is kicking ass here.

    Florida only posts COVID-19 data weekly these days. A new report in pdf form was just updated today. The new positive rate is 8.5% this week and 5.99% per the county health department for last week. So the 4th of July fireworks are still going off in the pandemic. Most are young people 16-30 yo. So will see if the hospital admissions start to increase as well. Expect the county health dept to ask us to mask-up on their Wednesday news release (once a week now).

    Read an article 1-2 weeks ago about the CDC reporting 4115 COVID breakthrough cases after people had been fully vaccinated w/Pfizer or Moderna 2x doses. Most
    were 65+ years old. So that freaked me out. Decided to sit back and watch.

    Read another article 2-3 days ago about a 64 yo in Texas that has the J&J 1 dose
    vaccination. He was just put on a ventilator at a Baylor hosiptal.

    So being more careful now.
    --
    APT1.1DM = SAID+T5 = SAID+(MARD/50) = T1.1, per Lancet 5 DM Groups.
    Insulinitis = Insulitis: â-cell destruction by lymphocytes, not a disease name. Islit, cellosis and diminosis are nonsense words used by 1 crazy person on Earth.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From AntiPro&T1.1DM@21:1/5 to All on Sat Jul 10 01:19:00 2021
    AntiPro&T1.1DM wrote:

    New model
    has an exponential decay after 30 days of uniform RBC cohort lifespan. 50% of A1c in last 30 days and 50% in 31-120 days set the exp rate constant for the RBC daily cohort weighted average.

    This simple exponential decay after 30 days to 120 days has a half-life
    of 22.5 days (rate constant of -3.07638794E-2) so half of the RBC cohort has been removed at 52.5 days. That is much faster than expected with 120 days
    as the average lifespan for the red blood cell (RBC) in normals. But my current
    curve fit has a correlation coefficient of .935 so very good. Just need more A1c data since I removed the low data as wrong via ALA corruption in assay.

    You take an average BG for each daily RBC cohort, i.e., what does each daily RBC cohort see as an average BG. Then weight it with the 30 day uniform and 31-120 day exp decay. That simulates the mixing of old and new RBCs. So it's a weighted average of average BGs seen by each daily RBC cohort. Then
    curve fit this weighted average of averages to your personal HbA1c data.

    The HbA1c moves much faster then you'd expect in this model. Interesting.
    --
    APT1.1DM = SAID+T5 = SAID+(MARD/50) = T1.1, per Lancet 5 DM Groups.
    Insulinitis = Insulitis: â-cell destruction by lymphocytes, not a disease name. Islit, cellosis and diminosis are nonsense words used by 1 crazy person on Earth.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Alan Mackenzie@21:1/5 to HELP_Pro!@everyday.thx on Sun Jul 11 20:19:44 2021
    AntiPro&T1.1DM <HELP_Pro!@everyday.thx> wrote:
    Alan Mackenzie wrote:

    Me. So he spins his wheels going nowhere fast. Oh well, what can he
    do?

    Actually, I still read your posts. I avoid Danny's posts, most of
    them, due to their prolixity, and the fact that they are usually
    highly offensive

    OK! Then just the three of us!

    That sounds like the start of a joke!

    So how is your new insulin therapy working out? What changes have you
    been forced into after porcine insulin was removed? How long before your body adjusted, stabilized to the change?

    Pretty well, to be honest. I'm needing quite a bit less insulin since
    the bovine Lente (not the porcine, which I still use) was withdrawn.
    That's less regular as well as less delayed action.

    The Levemir is sadly only available in cartridges, whose rubber seal is a
    lot tougher on the syringes than the traditional vial's rubber. Also,
    the cartridges are only 3ml., so I'm forever having to start a new one.
    Before you ask, I do this because I don't like injections, and using the cartridges as intended would mean five jabs per day rather than three.

    The adjustment time when I started on the Levemir was surprisingly brief. Mostly just the time required to cut the dose (by around 30%).

    I am contemplating the time when the pork insulin will become
    unavailable, too. I fear this will happen before my demise, so maybe I
    should look around for replacements now. The great thing about the pork regular is it produces dependable symptoms of hypoglycaemia. I don't
    know how well the newer analogues do this, though I spent nearly two
    decades on "human" regular, which was horrible stuff, pretty much lacking
    all hypo symptoms. I avoided dead-in-bed, though.

    My insulin therapy has been very stable after not using Humalog
    (Lispro). I've found my body has been changing as I age as well.
    More insuln resistance as I get older it seems. So I need to slow
    down the fast Novolog in the morning to produce a flat BG in the
    afternoon when I fast (no lunch). I do this by mixing with the old
    rDNA human Novolin Regular. Today fasting BG was 95mg/dl and I dosed
    3U Novolog mixed with 7U human Regular in 1 bolus. Test in progress
    to see if BG rises or lowers at 3 hours. But also have a slight
    hangover from 700mL Italian Grande Red last night. So insulin
    resistance is lower than usual this morning. Removed 2U for the booze effect. Will see.

    My therapy is a lot less mathematical. I reckon that if T1D hasn't done
    me any harm in 56 years, then it's not going to. So I don't bother
    calculating things the way you do, just inject as seems appropriate at
    the time and eat sensibly.

    My Doctor retired this year, so will see a new Doc in September. Both
    are in the same practice so records are shared.

    I got kicked out my diabetic practice last summer. I don't know if I
    mentioned it, but the practice insisted I sign up promising to have my
    blood tested four times a year, and four consultations a year, over which
    we had quite an argument. _I_ am going to decide when I need to consult
    a doctor, thank you very much, and I already spend more than enough time
    in doctors' practices. So we parted company, and I now get my regular
    supplies from my general practitioner. This is all caused by the
    bureaucracy of the German health system, but I'm thankful it's there,
    compared with what you folks have to put up with.

    Have not been posting much about COVID-19. But have been watching the
    local infection data that is rising from 4% to 6% positive rate for
    the last 2 weeks. The Delta variant from India is kicking ass here.
    So have started to mask-up again. The Lambda variant from Peru is
    also on the radar. So back to a semi- isolation as the new data rolls
    in.

    I still can't get excited about this disease. If it gets me, it gets me. Currently in Bavaria, we still have to wear a mask in shops and in public transport, but not any more in the fresh air.

    My last A1c was 6.5% so working to get it at 6% for September Doc
    appt. Current calculated A1c is 6.1% with a new math model under
    test. New model has an exponential decay after 30 days of uniform RBC
    cohort lifespan. 50% of A1c in last 30 days and 50% in 31-120 days
    set the exp rate constant for the RBC daily cohort weighted average.
    Removed very low A1c values in curve fit data as alpha lipoic acid bad
    data (too low, not believed).

    So long-term A1c experiment in progress too. (Elsa left no damage either.)

    Glad to hear it!

    --
    APT1.1DM = SAID+T5 = SAID+(MARD/50) = T1.1, per Lancet 5 DM Groups. Insulinitis = Insulitis: β-cell destruction by lymphocytes, not a
    disease name. Islit, cellosis and diminosis are nonsense words used
    by 1 crazy person on Earth.

    --
    Alan Mackenzie (Nuremberg, Germany).

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From AntiPro&T1.1DM@21:1/5 to Alan Mackenzie on Mon Jul 12 16:29:52 2021
    Alan Mackenzie wrote:

    Have not been posting much about COVID-19. But have been watching the
    local infection data that is rising from 4% to 6% positive rate for
    the last 2 weeks. The Delta variant from India is kicking ass here.
    So have started to mask-up again. The Lambda variant from Peru is
    also on the radar. So back to a semi- isolation as the new data rolls
    in.

    I still can't get excited about this disease. If it gets me, it gets me. Currently in Bavaria, we still have to wear a mask in shops and in public transport, but not any more in the fresh air.

    I had a strange hypoglycemic event that I think was Delta variant related. I get the shits from the vaccinations and suspected variant (alpha) infections. So my GI tract gets clobbered by the virus.

    So last Friday night, I dosed for dinner, normal routine with usual food. But two hours later I was hypoglycemic, as if my GI tract was not absorbing the dinner meal. I had to force a large amount to dried fruit on top of the usual meal to get BG to rise. I have no gastroparesis nor neuropathy. So shocked
    by this unexplained dinner-related hypoglycemia. Suspect I caught the Delta variant while shopping the previous day. Went to several stores to buy a few supplies but masked-up. But think the food I bought may have had the Delta variant on it. This had 1-2 days to incubate so probably the virus. OK now.

    But watching for this to happen again when isolated, then not the virus.
    --
    APT1.1DM = SAID+T5 = SAID+(MARD/50) = T1.1, per Lancet 5 DM Groups.
    Insulinitis = Insulitis: â-cell destruction by lymphocytes, not a disease name. Islit, cellosis and diminosis are nonsense words used by 1 crazy person on Earth.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Ozlover@21:1/5 to Alan Mackenzie on Tue Jul 13 14:38:03 2021
    Alan Mackenzie <acm@muc.de> wrote:
    AntiPro&T1.1DM <HELP_Pro!@everyday.thx> wrote:
    Alan Mackenzie wrote:

    Me. So he spins his wheels going nowhere fast. Oh well, what can he
    do?

    Actually, I still read your posts. I avoid Danny's posts, most of
    them, due to their prolixity, and the fact that they are usually
    highly offensive

    OK! Then just the three of us!

    That sounds like the start of a joke!

    It's even the four of us, but I'm only/mostly lurking. I've Danny
    filtered and also Jim's 'AntiPro&T1.1DM' nym, so I'm only seeing Jim's
    normal posts. I enjoy(ed) Jim's COVID related posts. (Jim, if you
    respond, please use your normal name/nym.)

    I'm still only or oral meds (glibenclamide (will change) and
    metformin). FBG/HbA1c are still well within the limits for my age, so no worries.

    [...]

    I got kicked out my diabetic practice last summer. I don't know if I mentioned it, but the practice insisted I sign up promising to have my
    blood tested four times a year, and four consultations a year, over which
    we had quite an argument. _I_ am going to decide when I need to consult
    a doctor, thank you very much, and I already spend more than enough time
    in doctors' practices. So we parted company, and I now get my regular supplies from my general practitioner. This is all caused by the
    bureaucracy of the German health system, but I'm thankful it's there, compared with what you folks have to put up with.

    My GP still handles my diabetes needs and I'm quite happy with him.
    Some time ago another GP temporary replaced him and wanted me to see the diabetes nurse, luckily that did not happen, because like you, *I*
    decide what I need and when, not some nurse who only follows a script.

    Have not been posting much about COVID-19. But have been watching the local infection data that is rising from 4% to 6% positive rate for
    the last 2 weeks. The Delta variant from India is kicking ass here.
    So have started to mask-up again. The Lambda variant from Peru is
    also on the radar. So back to a semi- isolation as the new data rolls
    in.

    We - The Netherlands - are back to a gigantic rise in infections, a
    factor 10 in a week and a R which is reportedly above 2, which it has
    never been. All caused by lifting too many restrictions too soon and
    people - especially youngsters - not following any rules and actively
    breaking test-for-access procedures. Bloody idiots.

    I still can't get excited about this disease. If it gets me, it gets me. Currently in Bavaria, we still have to wear a mask in shops and in public transport, but not any more in the fresh air.

    We hope we can go to Austria in 12 days time, but if the situation
    continues or gets worse - Austria or/and Germany may decide to lock us
    out (require quarantine). Fingers crossed.

    Take care you two!

    [...]

    --
    Frank Slootweg

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Jim@21:1/5 to Ozlover on Tue Jul 13 16:34:13 2021
    Ozlover wrote:

    Jim, if you respond, please use your normal name/nym.

    Hi Frank! OK, will use normal account for important info!

    Just the (approx 10) of us old timers then.

    Have not been posting much about COVID-19. But have been watching the
    local infection data that is rising from 4% to 6% positive rate for
    the last 2 weeks.

    We get weekly reports on Fridays and the last just was 8.5% for the county that Orlando is in. So the infection rate is jumping. Last nights local news said the county has imposed a mask mandate again. So the county health department is worried.

    Interestingly, my younger brother works with Brazilians; and, they are getting vaccinated for free as they get off the jet at the Orlando airport. He said Brazil is charging $1000 to get vaccinated and corruption is rampant. So we have free vaccine tourism here in Orlando.

    Most of the Trumper Republican states, where vaccinations are low, are the Delta variant hot spots. You can overlay a political map on the CDC hot spots and they match up nicely. So Trump is losing supporters in these areas if
    they get ventilated and survive.

    Read an article about a 90 yo Belgian Flemish woman that got infected by both the Alpha and Beta variants. She passed away but is the first known case of the
    double infection. This was last year, before vaccines.

    Have been boycotting Uber driving, as not worth the chance for infection. Will watch the infection rate for awhile and maybe calculate R0 numbers again.

    Stay safe Dude!
    --
    Jim
    T1 4/86, no complications, watching for IGF-I positive feedback loop.
    Nocturnal hypoglycemic seizures ended when stopped using Humalog (Lispro). Normal Dawn Phenomenon returned ~1 year later.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)