• Stomach stem cells in mice changed to insulin-producing cells?

    From _@21:1/5 to All on Fri May 26 08:19:49 2023
    May 25 2023 https://newatlas.com/medical/stomach-stem-cells-type-1-diabetes-cure/

    This treatment being researched in mice,
    might be a future cure for humans, -but- it
    remains in research on mice, unannounced
    when it might be tried in humans.

    The word "diabetics", used in the article, it's
    referring to individuals with Islit (new super-
    ior clarifying name for type 1 diabetes, indivi-
    duals whose endogenous insulin production
    is totally or near-totally lost) -and- possibly,
    it may also be referring to persons with other ...

    ... Disparate High Glucose Conditions that
    have severely reduced levels of endogenous
    insulin production (it's estimated, for exam-
    ple, that about 5% of individuals with Cellosis,
    the new superior clarifying name for type 2
    diabetes, use exogenous insulin, albeit many ...

    ... of them can reduce or eliminate their use
    of exogenous insulin via diet & exercise &
    using non-exogenous-insulin treatments).

    Stem cells in the human stomach perform
    the remarkable feat of regenerating intestinal
    lining every 5 to 7 days, cells which produce
    hormones.

    Researcher Joe Zhou has been working on
    experimenting with producing insulin in the
    mice stomach cells for 15 years. Despite
    working on this for 15 years, the article says
    they need to "optimize" their method increas-
    ing the scale of insulin-producing cells & ...

    ... somehow (undisclosed) modifying the
    cells to prevent the autoimmune attack
    that caused Islit in most individuals who
    have Islit. Mysterious how (or even if) they
    can do that as researchers have not yet
    come close to preventing Islit in humans ...

    ... who are vulnerable to an autoimmune
    attack on their own beta cells.

    ~~~

    Per the article, in 2021 there were 8.4 million
    humans with Islit (a number lower than I'd
    seen estimated elsewhere), & compared to
    the total population in 2021 of 7.9 billion,
    that's only 1/10th of 1% of the human popu-
    lation. I'd never heard that the % with Islit ...

    ... was that low in the world. Perhaps this
    article is mistaken with its 8.4 million fig-
    ure. I don't know.

    ~~~

    The study was published in Nature Cell
    Biology on April 27 2023:
    https://www.nature.com/articles/s41556-023-01130-y

    The abstract in that article doesn't men-
    tion any research into how to stop the
    autoimmune attack. None of the article
    mentions whether or not the mice (re-
    ferred to as "diabetic" mice) had auto-
    immune-caused Islit & in the mice ...

    ... researched as to transplanting insulin-
    producing stomach cells via the method
    above, they only watched the mice for 6
    months & didn't mention whether or not
    they were Islit mice or how they got what-
    ever Disparate High Glucose Condition ...

    ... they called diabetes. Were the mice
    Islit mice that had autoimmune caused
    Islit?

    Disappointing, the supposed promise of a
    "cure" but missing critical details.

    ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~

    Pro-Humanist FREELOVER, Insulinitis (Islit)
    since age 5, got it in March 1961 https://prohuman.net/pix2/new_superior_clarifying_name_is_INSULINITIS.jpg

    C.ure I.nsulinitis A.ssociation
    ASAP! https://prohuman.net/cureinsulinitisassociation.htm

    Glucose Anomalies Research regarding
    Potential Cures / Improvements in Treatments
    The Sooner The Better! https://prohuman.net/glucoseanomaliesresearch.htm

    - - -

    The old confusing way which all-too-often
    involves folks using the diabetes / diabetic
    words without a clarifier:

    diabetes / diabetic without a clarifier,
    diabetes / diabetic guessing required https://prohuman.net/pix2/diabetesdiabeticguessinggame.jpg

    - - -

    Logic and reasoning behind ceasing using
    diabetes & diabetic & reactive hypoglycemia
    words and phrases, replacing all that with
    vastly superior names, ending diabetes &
    diabetic & reactive hypoglycemia confusion,
    misleading, & misunderstanding:

    Diabetes Bubble / Diabetes Bubble Burst
    Splendid! https://prohuman.net/diabetesbubblediabetesbubbleburst.htm

    - - -

    Disparate High Glucose Conditions,
    DHGCs, 7 disparate categories of
    unpreventability / nonreversibility
    of all-but-one of the specific types
    of DHGCs (thus far, research actively
    trying to change that):

    o 15 specific types of rapid-onset Insul-
    initis (Islit), unpreventable & nonrevers-
    ible (thus far), the overwhelming majority
    with Islit have Insulitis Islit (sometimes
    called type 1 diabetes, often confusingly
    called diabetes with no clarifier) https://prohuman.net/pix2/new_superior_clarifying_name_is_INSULINITIS.jpg

    14 specific types of Islit are not caused
    by Insulitis, present in a small minority
    of those with Islit.

    o 1 specific type of slow-onset Islit, Latent
    Autoimmune Islit, also unpreventable &
    nonreversible (thus far) (sometimes called
    latent autoimmune diabetes in adults, often
    confusingly called diabetes with no clarifier)

    o Preventable Cellosis is the only specific
    type of DHGC that is preventable & revers-
    ible (in many, sometimes it's called type 2
    diabetes, often confusingly called diabetes
    with no clarifier)

    Risk for Preventable Cellosis, Hypertension,
    & Cardiovascular Disease increases as one's
    weight increases but BMI risk increases at
    lower BMI levels in non-white individuals: https://prohuman.net/pix2/BMI-WaistCircumference-Cellosis&Hypertension&CardiovascularDisease-Risk.jpg
    https://medicalxpress.com/news/2021-05-bmi-offs-obesity-diabetes-non-white.html

    PreCellosis (often confusingly called pre-
    diabetes with no clarifier) is the oft-times
    preventable & reversible Cellosis precondi-
    tion that all-too-often the overwhelming ma-
    jority having it are unaware they have it

    o 20 specific types of Cellosis, unpreven-
    table & nonreversible (thus far, sometimes
    called type 2 diabetes, all-too-often con-
    fusingly called diabetes with no clarifier)

    o 1 specific type of DHGC only occurring
    in the late stage of impregnation in women,
    a type that's transient but that increases
    risk of later getting Cellosis, that ...

    ... condition called Gestational Cellosis
    (sometimes called gestational diabetes,
    sometimes confusingly called diabetes with
    no clarifier).

    o 11 specific types of Diminosis (new name
    created in 2010 for a monogenic condition
    age 6 months that sometimes is called
    maturity onset diabetes of the young, some-
    times confusingly called diabetes with no
    clarifier), unpreventable & non-reversible
    (thus far).

    o 12 specific types of Neonatal Diminosis
    (new name created in 2010 for a monogenic
    condition at age < or = 6 months that some-
    times is called neonatal diabetes, sometimes
    confusingly called diabetes with no ...

    ... clarifier), 8 types are permanent & unpre-
    ventable & nonreversible (thus far); 4 specific
    types are transient but can recur.

    o 25 specific types of Ohiglucons (new name
    created in 2010 for other diabetes mellitus,
    but often confusingly called diabetes with
    no clarifier).

    23 specific types are totally unpreventable.

    Hemochromatosis Ohiglucon, is only preventa-
    ble if Hemochromatosis is found and treated
    before it damages the pancreas.

    Immunosuppressants Ohiglucon, caused after
    a transplant with the required use of immun-
    osuppressants, 50% is temporary, but if it
    persists for over a year, most likely the condi-
    tion is permanent.

    If endogenous insulin production is near-totally
    to totally lost & does not recover after immuno-
    suppressants dosages reduced, it causes Im-
    munosuppressants Islit.

    - - -

    A mostly Non-Glucose Anomaly, Insipidus, it's
    also unpreventable & nonreversible (thus far):

    o 6 specific types of Insipidus (new name
    created in 2010 for diabetes insipidus, some-
    times confusingly called diabetes with no clar-
    ifier), 4 specific types don't include high glucose
    & are unpreventable & nonreversible (thus far),
    2 specific rare types do include high glucose &
    are unpreventable & nonreversible (thus far).

    - - -

    The following condition is apart from the
    diabetes confusion problem, but has confu-
    sion issues of its own.

    A Low Glucose Condition, Hut:

    o The 21 specific types of Hut (new name
    created in 2010 for Hypoglycemia Uncaused
    by Treatments for High Glucose, often con-
    fusingly called reactive hypoglycemia, con-
    fusing in that it does not occur as a reac-
    tion to treatment for High Glucose; one ...

    ... form sometimes called hyperinsulinism),
    some specific types are preventable & rever-
    sible, some aren't (thus far).

    - - -

    Stop Diabetes/Diabetic Confusion
    with New Superior Clarifying Terms https://www.change.org/stopdiabetesdiabeticconfusionwithNewSuperiorClarifyingTerms

    ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~

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