• Re: Regulate Islit glucose levels by restoring pancreatic islet cell fu

    From _@21:1/5 to All on Thu Oct 21 14:19:32 2021
    Follow-up:

    - - -
    October 21 2021

    Vertex lab-created islet cells
    in a membrane packet https://www.fdanews.com/articles/204982-vertex-plans-ind-for-implantable-islet-cell-device-for-type-1-diabetes
    - - -

    Vertex Pharmaceuticals will submit an Inves-
    tigational New Device (IND) application next
    year for a drug/device combination that de-
    livers insulin-producing, lab-created islet cells
    in a membrane packet to protect them from
    the body’s immune system.

    The subcutaneous device is ready to enter hu-
    man trials, according to Felicia Pagliuca, the
    company’s Islit expert. It’s a critical part of
    Vertex’s core Islit program — a line of stem
    cell-derived islet cells (VX-880) that, once ...

    ... infused, cluster together in the liver and
    function as they would in a pancreas, sensing
    blood glucose levels and secreting insulin in
    the correct amount. ...

    On Sunday, February 21, 2021 at 5:34:36 PM UTC-6, _ wrote:

    = = = = = = = = = = = = = = = = = = = = = = =
    Islit (Insulinitis, near-total to total loss of
    endogenous insulin)
    o 15 specific types of rapid onset Islit
    o 1 slow onset type, Latent Autoimmune Islit
    = = = = = = = = = = = = = = = = = = = = = = =

    My translation of the article linked to below:

    Vertex aims to regulate Islit glucose levels by
    restoring pancreatic islet cell function, including
    insulin production, with VX-880, an allogeneic,
    human stem-cell derived, fully differentiated
    pancreatic islet cell therapy.

    Unfortunately, that therapy currently requires
    long-term immunosuppressive therapy to pre-
    vent immune rejection of pancreatic islet cells.

    The FDA has approved Vertex to begin a phase 1
    /phase 2 study of VX-880. The single-arm, open-
    label study will enroll about 17 patients with Islit
    who have impaired hypoglycemic awareness (aka
    hypoglycemia unawareness) and severe hypogly-
    cemia.

    Vertex plans to begin the trial in the first half of
    2021.

    - - -
    February 1 2021 https://www.healio.com/news/hematology-oncology/20210201/fda-clears-ind-application-for-stem-cell-therapy-to-treat-type-1-diabetes
    - - -

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    INSULINITIS (ISLIT)

    New SUPERIOR clarifying name for near-
    total to total loss of endogenous insulin https://prohuman.net/pix2/new_superior_clarifying_name_is_INSULINITIS.jpg

    The overwhelming majority of Islit caused by
    autoimmune attacks on pancreatic beta cells
    (Insulitis Islit) but there are

    o 15 specific types of rapid onset Islit, a
    rare condition (only present in < one-half
    of 1% of Americans & in a much lower rate
    in most of the world), when present is typ-
    ically diagnosed at age under 30
    (50% at age < 18, 20% at age 19 to 29)

    o 1 slow onset specific type, Latent Autoim-
    mune Islit, frequency unknown but per a
    recent report, misdiagnosed as Cellosis
    (new clarifying name for type 2 diabetes)
    almost 40% of the time due to its slow
    onset and its occurrence typically at age
    over 30

    Old outdated anachronistic name for Islit is
    type 1 diabetes, confusing in that diabetes
    without clarifier is often used to describe
    this condition which is 1 of the 7 Disparate
    High Glucose Conditions (DHGCs).

    That makes figuring out which DHGC is actu-
    ally being referred to (and it can be any one,
    or some, or all of them when the diabetes
    or diabetic word is used without clarifier)
    confusing / difficult: https://prohuman.net/pix2/diabetesdiabeticguessinggame.jpg https://prohuman.net/pix2/diabetesdiabeticconfusion.jpg https://prohuman.net/pix2/diabetesdiabeticendingthemisunderstanding.jpg

    - - -

    Insulin / Insulin Pump / CGM I use

    Fiasp Ultra-Fast-Acting Insulin in a
    tubeless Omnipod insulin pump catheter
    placed into skin / pod with adhesive
    stuck onto skin every 80 hours, control
    via PDM (Personal Data Manager) https://prohuman.net/pix2/Fiaspinsulin_tubelessOmnipodDASHinsulinpump.jpg

    Dexcom G6 CGM (continuous glucose monitor) https://prohuman.net/pix2/Dexcom_G6_CGM.jpg

    - - -

    Superior Clarifying Names first created
    and defined in 2010, trying to replace
    outdated anachronistic confusing misleading
    diabetes / diabetic / reactive hypoglycemia
    words and phrases:

    Diabetes Bubble / Diabetes Bubble Burst
    Exemplary! https://prohuman.net/diabetesbubblediabetesbubbleburst.htm

    C.ure I.nsulinitis A.ssociation
    Outstanding! https://prohuman.net/cureinsulinitisassociation.htm

    Glucose Anomalies Research regarding
    Potential Cures / Improvements in Treatments
    Sooner is Ideal! https://prohuman.net/glucoseanomaliesresearch.htm

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