• =?UTF-8?Q?Synthetic_hinges_can_hold_the_key_to_innovative_=E2=80=9Cs?=

    From _@21:1/5 to All on Mon Aug 2 12:34:17 2021
    Glucose-aware insulin, a goal that has been
    aspired to by many companies over the years,
    I rarely read any articles about progress in this
    area, & the articles are reluctant to call smart
    glucose-aware insulin a 'cure', despite its pur-
    ported capability to avoid hypoglycemia -and-
    hyperglycemia.

    Here's a bit of research on a synthetic insulin
    hinge being worked on by Michael A. Weiss,
    MD, a prominent professor at Indiana University
    School of Medicine.

    - - -
    August 2 2021 https://floridanewstimes.com/synthetic-hinges-can-hold-the-key-to-innovative-smart-insulin-therapy/316821/
    - - -

    The article mentions glucose levels 70 mg/dl as a
    'turn-off' point -and- 180 mg/dl as a 'turn-on' point,
    but actually, in folks with a fully functional pancreas,
    insulin 'turns off' at 83 mg/dl & assorted endogenous
    hormonal reactions transpire to prevent hypoglycemia.

    Also, endogenous insulin responds immediately to
    glucose rises at sub-100 mg/dl & prevents almost all
    glucose rises > 140 mg/dl, never allowing glucose lev-
    els to go above 180 mg/dl, per the following post of
    153 individuals who have fully functional pancreases
    (i.e., no Disparate High Glucose Condition), ages 7 to
    80 ... https://groups.google.com/g/misc.health.diabetes/c/4E_1OM3ZzSk/m/LIj0zVsWAwAJ

    ... here's what their glucose levels were with up to 10
    days of wearing a 'blinded' Dexcom G6 continuous
    glucose monitor (CGM), i.e., the 153 individuals did
    not view their glucose levels:

    % of glucose levels > 180 mg/dL ... 0%
    % of glucose levels 160.1 to 180 mg/dl ... 3/10ths of 1%
    % of glucose levels 140.1 to 160 mg/dl ... 2.1%
    % of glucose levels 70 to 140 mg/dl ... 96%
    % of glucose levels 70 to 120 mg/dl ... 89%
    % of glucose levels 60 to 69.9 mg/dl ... 1.1%
    % of glucose levels 54 to 59.9 mg/dl ... 2/10ths of 1%
    % of glucose levels < 54 mg/dl ... 0%

    * - * - * - * - * - * - * - * - * - * - * - * - * - * - * - * - * - *

    For clarity about the -7- Disparate High Glucose
    Conditions (DHGCs) with -85- specific types, refer
    to the following:
    https://prohuman.net/diabetesbubblediabetesbubbleburst.htm https://prohuman.net/pix2/diabetesbubblediabetesbubblebursttitle.jpg https://prohuman.net/pix2/diabetesreactivehypoglycemiaoldnamesnewnames.jpg https://prohuman.net/pix2/oldnamesnewimprovednames.jpg

    Also, -6- specific types of a mostly non-glucose
    anomaly Insipidus -and- -21- specific types of
    Hypoglycemia Uncaused by Treatments for
    High Glucose (Hut) are fully explained at the
    following, beauteous bountiful Knowledge &
    Power:

    Everything You Ever Wanted to Know about
    DHGCs, Insipidus, & Hut, but were afraid to
    ask (or due to diabetes confusion, not knowing
    enough to ask):
    https://prohuman.net/diabetesbubblediabetesbubbleburst.htm

    - - -

    Stop Diabetes/Diabetic Confusion
    with New Superior Clarifying Terms https://www.change.org/stopdiabetesdiabeticconfusionwithNewSuperiorClarifyingTerms

    * - * - * - * - * - * - * - * - * - * - * - * - * - * - * - * - * - *

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