• Islit In the News as of July 28 2021

    From _@21:1/5 to All on Wed Jul 28 11:08:41 2021
    Islit - Insulinitis, near-total to total loss of
    endogenous insulin, requires exogenous
    insulin dosages, both basal - background
    & bolus - dealing with glucose rises typic-
    ally caused by eating or drinking (though
    other factors are involved, adding to its ...

    ... unpredictable probabilistic nature), espe-
    cially eating or drinking carbohydrates.

    ~~~

    Some recent articles about Islit:

    - - -
    July 28 2021

    Rice University team creating insulin-producing
    implant for Islit (with help from JDRF - Islit Re-
    search Foundation) https://indiaeducationdiary.in/rice-university-rice-team-creating-insulin-producing-implant-for-type-1-diabetes/
    - - -

    Rice University bioengineers are using 3D printing
    & smart biomaterials to create an insulin-producing
    implant for Islit individuals.

    The 3-year project is a partnership between the lab-
    oratories of Omid Veiseh and Jordan Miller that’s
    supported by a grant from JDRF, the leading global
    funder of Islit research. Veiseh and Miller will use
    insulin-producing beta cells made from human stem
    cells to create an implant that senses and regulates ...

    ... (i.e., insulin lowers glucose but other hormonal
    & cellular activities are required to counter hypogly-
    cemia) blood glucose levels by responding with the
    correct amount of insulin at a given time.

    Veiseh, an assistant professor of bioengineering,
    has spent more than a decade developing bioma-
    terials that protect implanted cell therapies from the
    immune system.

    Miller, an associate professor of bioengineering, has
    spent more than 15 years researching techniques to
    3D print tissues with vasculature, or networks of blood
    vessels.

    “If we really want to recapitulate what the pancreas
    normally does, we need vasculature,” Veiseh said.
    “And that’s the purpose of this grant with JDRF. The
    pancreas naturally has all these blood vessels, & cells
    are organized in particular ways in the pancreas. Jor-
    dan & I want to print in the same orientation that exists
    in nature.”

    Veiseh’s & Miller’s goal is to show their implants can
    properly regulate blood glucose levels of Islit mice for
    at least 6 months. To do that, they’ll need to give their
    engineered beta cells the ability to respond to rapid
    changes in blood glucose levels.

    [see article for further details, obviously mice are the
    1st test, & if that test is successful & proven to be safe,
    human tests may follow but as this is early reserach, it
    may be many years before this goes thru human clini-
    cal trials]

    ~~~

    Interesting test of substance to restore endogenous
    glucagon secretion to reduce (or ideally, eliminate)
    hypoglycemia in Islit individuals:

    - - -
    July 28 2021

    Zucara Therapeutics Doses First Islit
    Individuals in Phase 1b Trial of ZT-01 https://pipelinereview.com/index.php/2021072878839/Small-Molecules/Zucara-Therapeutics-Doses-First-Patients-in-Phase-1b-Trial-of-ZT-01.html
    - - -

    ... Zucara Therapeutics is developing ZT-01, a first-in-
    class once-daily therapeutic to prevent insulin-induced
    hypoglycemia in Islit individuals.

    ZT-01 is designed to inhibit somatostatin, a pancreatic
    hormone that impairs the glucagon response to hypo-
    glycemia in people with Islit.

    ZT-01 restores glucagon secretion to prevent hypogly-
    cemia ...

    ~~~

    Research on a possible vaccine to prevent
    Insulitis-caused Islit, the specific type of Islit
    that the overwhelming majority of those with
    Islit have, caused by an autoimmune attack
    on pancreatic beta cells (Insulitis), near-totally
    or totally destroying them.

    To be perfectly honest, I had no earthly idea
    of what the researcher was talking about in
    this article, but hopefully, at some point in the
    future what he's talking about will be able to
    develop a way to prevent Insulitis-caused Islit.

    Unfortunately, his research is totally preventa-
    tive, not curative, & won't help anyone of the
    estimated 20 million worldwide who already
    have any of the 15 specific types of Islit.

    - - -
    July 27 2021

    Dr Aleksandar Kostic Outlines His Research
    on an Insulitis-Caused Islit Vaccine https://www.ajmc.com/view/dr-aleksandar-kostic-outlines-his-research-on-a-t1d-vaccine
    - - -

    ~~~

    Genetic Research, not to be too skeptical, but
    OK, I won't be skeptical, I'll simply report on
    what the following article has discovered about
    Insulitis-caused Islit genetics:

    - - -
    July 27 2021

    African & Asian genetics researched along
    with European genetics research into genetic
    causes of Insulitis Islit https://wydaily.com/regional/2021/07/27/uva-scientists-mount-diverse-study-to-help-treat-diabetes/
    https://wydaily.com/regional/2021/07/27/uva-scientists-mount-diverse-study-to-help-treat-diabetes/
    - - -

    ... the scientists identified 78 regions on
    human chromosomes where genes are
    located that influence our risk for Insulitis-
    caused Islit. Of those, 36 regions were
    previously unknown. ...

    Sidenote: The article hopes this knowledge
    will help in the search for a cure, but when
    it comes to a cure, I suspect figuring out
    ways to recreate endogenous insulin pro-
    duction are much more likely to enable a
    cure than is genetic research, just saying.

    ~~~

    In a cool article about the actors & actresses
    starring in Wizards of Waverly Place, I discov-
    ered that actress Jennifer Stone got Latent
    Autoimmune Islit (often thought of as a condi-
    tion that occurs at ages 30 and above) at the
    young age of 20, in 2013.

    - - -
    July 27 2021

    Wizards of Waverly Place's Jennifer Stone
    diagnosed with Latent Autoimmune Islit in
    2013, at the young age of 20. https://www.the-sun.com/entertainment/tv/3360924/wizards-of-waverly-place-original-disney-cast-now/
    - - -

    Jennifer ... appeared in every single episode
    of Wizards of Waverly Place as Alex's (played
    by Selena Gomez, who was diagnosed with
    Lupus, an autoimmune disorder like Insulitis-
    caused Islit, in late 2013 or early 2014, got a
    kidney transplant from a friend in 2017) best
    friend.

    Her having Latent Autoimmune Islit
    discussed briefly at her wikipedia page https://en.wikipedia.org/wiki/Jennifer_Stone

    ~~~ ~~~ ~~~ ~~~ ~~~ ~~~ ~~~ ~~~ ~~~

    INSULINITIS (ISLIT)

    New SUPERIOR clarifying name for near-
    total to total loss of endogenous insulin https://prohuman.net/pix2/new_superior_clarifying_name_is_INSULINITIS.jpg

    The overwhelming majority of Islit caused
    by autoimmune attacks on pancreatic beta
    cells (Insulitis Islit) but there are

    o 15 specific types of rapid onset Islit, a
    rare condition (only present in < one-half
    of 1% of Americans & in a much lower rate
    in most of the world), when present is typ-
    ically diagnosed at age under 30
    (50% at age < 18, 20% at age 19 to 29)

    o 1 slow onset specific type, Latent Auto-
    immune Islit, frequency unknown but per
    a recent report, misdiagnosed as Cellosis
    (new clarifying name for type 2 diabetes)
    almost 40% of the time due to slow onset
    & occurrence typically at age over 30

    Old outdated anachronistic name for Islit is
    type 1 diabetes, confusing in that diabetes
    without clarifier is often used to describe this
    & the other 6 Disparate High Glucose Con-
    ditions (DHGCs).

    That makes figuring out which DHGC is actu-
    ally being referred to (& it can be any 1, some,
    or all of them when diabetes or diabetic word
    used without clarifier) confusing / difficult: https://prohuman.net/pix2/diabetesdiabeticguessinggame.jpg https://prohuman.net/pix2/diabetesdiabeticconfusion.jpg https://prohuman.net/pix2/diabetesdiabeticendingthemisunderstanding.jpg

    Recent estimate that 20 million have Islit in the
    world, 1 in 394 (2.583/10ths of 1%), less than
    5% of the almost 470 million in the world who
    have any of the 7 DHGCs, 95% having Cellosis
    (see below for causalities): https://groups.google.com/g/misc.health.diabetes/c/58ZoHZEZ51w/m/EBejqoJQAQAJ

    Notably, one's relatives and one's birthplace
    dramatically impact one's risk of getting the
    Insulitis-caused Islit, as listed in details of all
    15 specific types of rapid-onset Islit & the sole
    specific type of slow onset Latent Autoimmune
    Islit at https://groups.google.com/g/misc.health.diabetes/c/aOsrugeqYqs/m/MlI8I6PzAAAJ

    - - -

    Insulin / Insulin Pump / CGM I use

    Fiasp Ultra-Fast-Acting Insulin in a tubeless
    Omnipod insulin pump catheter placed into
    skin / pod with adhesive stuck onto skin every
    80 hours, control via PDM (Personal Data
    Manager) https://prohuman.net/pix2/Fiaspinsulin_tubelessOmnipodDASHinsulinpump.jpg

    Dexcom G6 CGM (continuous glucose monitor) https://prohuman.net/pix2/Dexcom_G6_CGM.jpg

    - - -

    Stop Diabetes/Diabetic Confusion
    with New Superior Clarifying Terms https://www.change.org/stopdiabetesdiabeticconfusionwithNewSuperiorClarifyingTerms

    - - -

    o Preventable Cellosis is the only specific
    type of Disparate High Glucose Condition
    that is preventable & reversible (in many,
    sometimes it's called type 2 diabetes, often
    confusingly called diabetes with no clarifier)

    Risk for Preventable Cellosis, Hypertension,
    & Cardiovascular Disease increases as one's
    weight increases but BMI risk increases at
    lower BMI levels in non-white individuals: https://prohuman.net/pix2/BMI-WaistCircumference-Cellosis&Hypertension&CardiovascularDisease-Risk.jpg
    https://medicalxpress.com/news/2021-05-bmi-offs-obesity-diabetes-non-white.html

    o PreCellosis (often confusingly called predia-
    betes with no clarifier) is the oft-times preven-
    table & reversible Cellosis precondition that all-
    too-often the overwhelming majority having it
    are unaware they have it (almost 3 times more
    have PreCellosis than have Cellosis).

    o 20 specific types of Cellosis, unpreventable
    & nonreversible (thus far, sometimes called
    type 2 diabetes, all-too-often confusingly called
    diabetes with no clarifier)

    Per the following article, 5.3% with Cellosis
    used exogenous insulin in 2019. https://www.bloomberg.com/press-releases/2019-12-13/tandem-diabetes-care-announces-fda-clearance-of-the-t-slim-x2-insulin-pump-with-control-iq-advanced-hybrid-closed-loop

    - - -

    o 4 other Disparate High Glucose Conditions
    exist (Gestational Cellosis, Diminosis, Neonatal
    Diminosis, Ohiglucons), all 7 DHGCs fully des-
    cribed in the following article:

    Logic and reasoning behind ceasing using
    confusing / misleading / misinforming diabetes
    & diabetic & reactive hypoglycemia words and
    phrases, replacing all of that with vastly superior
    clarifying names:

    Diabetes Bubble / Diabetes Bubble Burst https://prohuman.net/diabetesbubblediabetesbubbleburst.htm

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