Minocycline attenuates brain injury and iron overload after intracerebral hemorrhage in aged female rats.ischemic stroke. However, there is evidence in cerebral ischemia that minocycline is not protective in aged female animals. Since most ICH research has used male models, this study was designed to provide an overall view of ICH-induced iron deposits at
Dai S1, Hua Y2, Keep RF2, Novakovic N2, Fei Z3, Xi G4.
Neurobiol Dis. 2018 Jun 4. pii: S0969-9961(18)30173-6.
doi: 10.1016/j.nbd.2018.06.001.
Abstract
Brain iron overload is involved in brain injury after intracerebral hemorrhage (ICH). There is evidence that systemic administration of minocycline reduces brain iron level and improves neurological outcome in experimental models of hemorrhagic and
KEYWORDS:
Aging; Ferritin; Heme oxygenase-1; Intracerebral hemorrhage; Iron; Magnetic resonance imaging; Microglia; Minocycline
PMID: 29879529 DOI: 10.1016/j.nbd.2018.06.001
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