1. Forum
  2. Usenet
  3. MISC.EMERG-SERVICES

  • Iron In Stroke

    From ironjustice@21:1/5 to All on Thu May 10 04:04:57 2018
    Hemoglobin metabolism by-products are associated with an inflammatory response in patients with hemorrhagic stroke.
    Rev Bras Ter Intensiva. 2018 Mar;30(1):21-27. doi: 10.5935/0103-507x.20180003. Epub 2018 Mar 15.
    Righy C1, Turon R2, Freitas G3, Japiassú AM1, Faria Neto HCC4, Bozza M5, Oliveira MF6, Bozza FA1.

    Abstract
    OBJECTIVE:
    To evaluate the relationships of brain iron and heme with the inflammatory response of the systemic and central nervous systems and to investigate the role of defensive systems against the toxicity of iron and heme in the central nervous system.

    METHODS:
    We assessed a prospective cohort of patients presenting with intracerebral and subarachnoid hemorrhage. We assayed plasma and cerebrospinal fluid samples for the presence of iron, heme, hemopexin, haptoglobin, enolase, S100-β and cytokines for the first
    three days following hemorrhagic stroke. We also analyzed the dynamic changes in these components within both fluids and their relationship with early mortality rates.

    RESULTS:
    Hemopexin and haptoglobin concentrations were nearly negligible in the brain after intracerebral and subarachnoid hemorrhage. Cerebrospinal fluid iron and heme concentrations correlated with a pro-inflammatory response in the central nervous system, and
    plasmatic and cerebrospinal fluid inflammatory profiles on the third day after hemorrhagic stroke were related to early mortality rates. Interleukin 4 levels within the cerebrospinal fluid during the first 24 hours after hemorrhagic stroke were found to
    be higher in survivors than in non-survivors.

    CONCLUSION:
    Iron and heme are associated with a pro-inflammatory response in the central nervous system following hemorrhagic stroke, and protections against hemoglobin and heme are lacking within the human brain. Patient inflammatory profiles were associated with a
    poorer prognosis, and local anti-inflammatory responses appeared to have a protective role.

    PMID: 29742229 DOI: 10.5935/0103-507x.20180003

    Who loves ya.
    Tom


    Jesus Was A Vegetarian!
    http://tinyurl.com/634q5a

    Man Is A Herbivore!
    http://tinyurl.com/4rq595

    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)