• Risks Digest 31.91 (3/3)

    From RISKS List Owner@21:1/5 to All on Fri May 29 23:03:06 2020
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    extra therapy was given because of a small ulceration, an inch in diameter, secondarily infected by rupture of the vesicles by a corset stave prior to
    the first visit. Vitamin C apparently had no effect on this lesion, which
    was healed in two weeks under compound tincture of benzoin locally and penicillin and sulfadiazine by mouth. (The patient objected to taking penicillin by needle.) One of the patients, a man of 65, came to the office doubled up with abdominal pain and with a history of having taken opiates
    for the preceding 36 hours. He gave the impression of having an acute
    surgical condition. A massive array of vesicles extended from the dorsal
    nerve roots to the umbilicus, a hand's breadth wide. He was given 3000
    mg. of vitamin C intravenously and directed to return to the office in four
    to five hours. It was difficult to convince him that his abdominal pain was
    the result of his having "shingles." He returned in four hours completely
    free of pain. He was given an additional 2000 mg. of vitamin C, and
    following the schedule given above he recovered completely in three days.

    In herpes simplex it is important to continue the treatment for at least 72 hours. We have seen "fever blisters" that appeared healed after two
    injections recur when therapy was discontinued after 24 hours. Vitamin C in
    a strength of 1000 mg. per 10 c.c. of buffered solution gave no response
    when applied locally. This was true no matter how often the applications
    were made. In several cases 10 mg. of riboflavin by mouth t.i.d. in
    conjunction with the vitamin C injections appeared to cause faster healing.

    Chickenpox gave equally good response, the vesicles responding in the same manner as did those of herpes. These vesicles were crusted after the first
    24 hours, and the patient well in three to four cays. We interpreted this similarity of response in these three diseases to suggest that the viruses responsible were closely related to one another.

    Many cases of influenza were treated with vitamin C. The size of the
    dose and the number of Injections required were in direct proportion to
    the fever curve and to the duration of the illness. Forcing of fruit
    juice was always recommended, because of the frequency and ease of
    reinfection during certain periods of the year.

    The response of virus encephalitis to ascorbic acid therapy was
    dramatic. Six cases of virus encephalitis were treated and cured with
    vitamin C injections. Two cases were associated with virus pneumonia; one followed chickenpox, one mumps, one measles and one a combination of measles and mumps. In the case that followed the measles-mumps complex, definite evidence was found to confirm the belief that massive, frequent injections
    are necessary in treating virus infections with vitamin C. This lad of eight years was first seen with a temperature of 104°. He was lethargic, very irritable when molested. His mother said he had gradually developed his present clinical picture over the preceding four or five days. His first symptom was anorexia which became complete 36 hours before his first examination. He next complained of a generalized headache, later be became stuporous. Although very athletic and active, he voluntarily took to his
    bed. He was given 2000 mg. of vitamin C intravenously and allowed to return home because there were no available hospital accommodations. His mother was asked to make an hourly memorandum of his conduct until his visit set for
    the following day. Seen 18 hours after the initial injection of vitamin C,
    the memorandum revealed a quick response to the antibiotic -- after two
    hours he asked for food and ate a hearty supper, then played about the house
    as usual and then, for .several hours, he appeared to have completely recovered. Six hours following the initial injection, he began to revert to
    the condition of his first visit. When seen the second time temperature was 101.6°, he was sleepy but he would respond to questions. The rude
    irritability shown prior to the first injection was strikingly absent. A
    second injection of 2000 mg. vitamin C was given intravenously and 1000
    mg. of "C" prescribed every two hours by mouth. The next day he was fever
    and symptom-free. As a precautionary measure a third 2000 mg. was given with direction to continue the drug by mouth for at least 48 hours. He has
    remained well since. A lad of 12 years had generalized headache a week after having mumps, this followed by malaise, and in 12 hours a lethargic state
    and a fever of 105°. Admitted to hospital he was given 2000 mg. of vitamin C then, and 1000 mg. every two hours. Following the third injection he was sitting up in bed, laughing, talking, begging for food and completely
    without pain. He was discharged 24 hours following admission clinically
    well. Since relapses do occur if the drug is discontinued too soon, he was given 2000 mg. of vitamin C every 12 hours for two additional days.

    The use of vitamin C in measles proved to be a medical curiosity. During an epidemic vitamin C was used prophylactically and all those who received as
    much as 1000 mg. every six hours, by vein or muscle, were protected from the virus. Given by mouth, 1000 mg. in fruit juice every two hours was not protective unless it was given around the clock. It was further found that
    1000 mg. by mouth, four to six times each day, would modify the attack; with the appearance of Koplik's spots and fever, if the administration was
    increased to 12 doses each 24 hours, all signs and symptoms would disappear
    in 48 hours. If the drug was discontinued or reduced to three or four doses each 24 hours following the disappearance of Koplik's spots, within another 48-hour period the fever, the conjunctivitis and Koplik's spots would be
    back.

    It was our privilege to observe this picture over and over in two little volunteer girls for 30 days. These "research helpers" were my own little daughters. The measles virus was eventually destroyed in this instance by continuing 12,000 mg. by mouth each 24 hours for four days. We interpreted
    this result to indicate that on withdrawing the drug with the cessation of signs and symptoms, a small quantity of the virus remained, which after
    another incubation period produced anew the first stage of measles; when the drug was continued beyond the clearing stage the virus was destroyed in
    toto. No case of post-measles bronchopneumonia was seen. The "measles-cough"
    of measles bronchitis was over with after three or four 1000 mg. injections
    of "C" at 6-hour intervals. This was true even when other medications well above the calculated dose range for cough had had no effect. Whenever a
    patient presented a mixed-virus infection, such as receding mumps and developing measles, it was found that double the calculated dose of vitamin
    C was necessary to obtain the usual results.

    Of mumps, 33 cases were treated with ascorbic acid. When vitamin C was given
    at the peak of the infection the fever was gone within 24 hours, the pain within 36 hours, the swelling in 48 to 72 hours. Two cases were complicated with orchitis. A young man of 23 years developed bilateral orchitis one
    Friday morning, by seven o'clock that night he was in severe pain, had a
    fever of 105" and was nursing testicles the size of tennis balls. Vitamin C
    was started at this time—1000 mg. every two hours, intravenously. The pain began to subside following the first injection and ceased in 12 hours. There was no fever after 36 hours. The patient was out of bed feeling his old
    self after 60 hours. He had received 25,000 mg. of "C" in this 60-hour
    period. An experiment involving three cousins: One, a boy of seven, had the
    old routine of bed rest, aspirin, and warm camphor oil applications and
    iodex to the swollen glands. This child had a rough time for a week. A
    second boy, aged 11, was allowed to develop mumps to the point of maximum swelling without any therapy, then given vitamin C, 1000
    mg. intramuscularly, every two to four hours. This lad was entirely well in
    48 hours. To the third patient, a girl of 9, vitamin C was given on the up curve when the swellings were 60 per cent of the expected, and the
    temperature recorded at 102.3°. The dose was 1000 mg. of vitamin C given intravenously every four hours. This child was well and remained so from the third day of treatment.

    Further studies on virus pneumonia showed that the clinical response was
    better when vitamin C was given to these patients according to the dose schedule outlined for poliomyelitis. Where pneumonitis was demonstrated, the clearing of the chest film was parallel with the clinical recovery. In cases
    of consolidation of entire lobes the x-ray clearing lagged days behind the clinical response. In these cases 1000 mg. of "C" should be given every 12 hours for at least a week after the patient is apparently well. There was no change in the results as given in a previous paper; the patients were well
    in the third day of treatment.

    In using vitamin C as an antibiotic no factor of toxicity need be
    considered. To confirm this observation 200 consecutive hospital patients
    were given ascorbic acid, 500 to 1000 mg. every four to six hours, for five
    to ten days. One volunteer received 100,000 mg. in a 12-day period. It must
    be remembered that 90 per cent of these patients did not have a virus
    infection to assist in destroying the vitamin. In no instance did
    examination of the blood or urine indicate any toxic reaction, and at no
    time were there any clinical manifestations of a reaction to the drug. When vitamin C was given by mouth one per cent of these patients vomited shortly after taking the drug. In half of these cases the vomiting was controlled by increasing the carbohydrate content of the mixture. This reaction was not interpreted as representing a toxic manifestation; rather it was thought to
    be due to a hypersensitive gastric mucosa. The dose was reduced from 1000 to 100 mg. in young children showing this complex; vomiting occurred as
    before. However, in these same patients administration of massive, frequent doses of vitamin C by needle affected a cure of the infection without
    causing vomiting.

    From a review of the literature one can safely state that in all instances
    of experimental work with ascorbic acid on the virus organism the amount of virus used was beyond the range of the administered dose of this vitamin. No one would expect to relieve kidney colic with a five-grain aspirin tablet;
    by the same logic we cannot hope to destroy the virus organism with doses of vitamin C of 10 to 400 mg. The results which we have reported in virus
    diseases using vitamin C as the antibiotic may seem fantastic. These
    results, however, are no different from the results we see when
    administering the sulfa, or the mold-derived drugs against many other kinds
    of infections. In these latter instances we expect and usually get 48- to 72-hour cures; it is laying no claim to miracle-working then, when we say
    that many virus infections can be cleared within a similar time limit.

    Comment by R Cathcart: This paper repeatedly refers to intramuscular vitamin
    C. My personal experience, my talking with Klenner, and with his wife,
    Annie Klenner, who served as his nurse, would indicate that he used sodium ascorbate. Vitamin C as ascorbic acid is too acid for intramuscular
    injections or intravenous injections. Commercially prepared vitamin C solutions for injection may be labeled ascorbic acid but are buffered. Unfortunately, these may still be somewhat acid. They should never contain preservatives. See my article on how to make intravenous C solutions. These are also appropriate for intramuscular injections. The vitamin C when used orally is best in the ascorbic acid form if tolerated by the patient. I am especially indebted to Annie Klenner for her descriptions of how Fred made
    the sodium ascorbate solutions for .intravenous and intramuscular use.

    André Carezia, Eng. de Telecomunicações,
    Carezia Consultoria - www.carezia.srv.br

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    Date: Mon, 14 Jan 2019 11:11:11 -0800
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