Since ancient times, people have used psychedelics that are found in nature for their therapeutic effects. Examples include psilocybin extract from magic mushrooms, psilocybin mushroom chocolate bars with LSD blotters, DMT vape pens, MDMA, and mescaline.
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The classification of psychedelic substances such as psilocybin and LSD as drugs of abuse without any medical use has, however, hindered research on the therapeutic effects of these substances.
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Naturally occurring psychedelic substances such as psilocybin extract from magic mushrooms and mescaline have been used for their beneficial health effects for thousands of years.
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Microdosing refers to the practice of regularly using small amounts of psychedelic substances that do not impair cognitive function.
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The researchers also found that older microdosers showed larger improvements in the psychomotor test, but not cognitive function, than non-microdosers. This effect was largely due to older participants over the age of 55 years using a combination of
psilocybin, lion’s mane, and niacin.
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In recent years, there has been a resurgence of scientific and popular interest in the potential use of psychedelic drugs for the treatment of depression, anxiety, and post-traumatic stress. For instance, psilocybin, the active ingredient in magic
mushrooms, has shown a tusted Source promise in the treatment of individuals with depression, anxiety, and substance use disorders.
These studies have generally used regular doses of psilocybin that produce euphoric and hallucinogenic effects. However, the use of regular doses of psilocybin can also produce unpleasant and terrifying experiences, also referred to as “bad trips”
The researchers found that microdosers showed greater improvements in mood and larger reductions in symptoms of depression, anxiety, and stress over the study period than non-microdosers.
These positive effects of microdosing were observed in all participants, regardless of whether they used psilocybin alone or a combination of either psilocybin with lion’s mane, or psilocybin, lion’s mane, and niacin.
Moreover, microdosing psilocybin resulted in similar levels of improvements in mental health and mood across age groups, genders, and among individuals who did or did not have mental health concerns.
The only exception was female microdosers who showed larger reductions in depressive symptoms than males.
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In sum, the results of this study add to the current evidence on the beneficial effects of microdosing psilocybin on mental health and mood, including among individuals with mental health concerns.
Microdosing benefits: More research needed
Although the study had a large sample size, the number of individuals in various subgroups according to age, gender, and substances used for microdosing was relatively small. Thus, these findings need to be replicated with larger sample sizes.
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Dr. Balázs Szigeti, a postdoctoral researcher at Imperial College London, also noted that the present study used a control group but placebo effects in the microdosing group cannot be ruled out.
Dr. Szigeti explained:
“This study used a natural history control condition, meaning that the control group did not have any treatment. This is a weak control condition, although certainly better than not having any control group as in purely observational studies.” https:/
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“Relative to this weak control, microdosers showed some improvements, mostly with moderate effect sizes. This means that on most scales the magnitude of the improvements was only modest. Therefore, this study helps to establish that in uncontrolled /
weakly controlled studies microdosing shows some benefits,” he continued.
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Microdoses of psychedelic mushrooms may improve mood and mental health
Microdosing refers to the practice of regularly using small amounts of psychedelic substances that do not impair cognitive function.
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