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DMT vape pen combines either N,N,DMT or 5-MeO-DMT with an e-liquid base. It’s then added to a standard vaporizer, just like the type you’ll find from cannabis manufacturers.
In fact, you can even use DMT vape cartridges with any standard cartridge-style vape pens. These pens are often sold with CBD, THC, or nicotine cartridges. When the tank is empty, it’s removed, and a fresh new tank is screwed into its place.
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Vape pens are designed to heat the contents without burning them. The DMT and its base agent (usually e-liquid) are heated just enough to convert into a vapor which can then enter the lungs for absorption. Vape pens typically heat the active ingredients
to around 400ºF (204ºC).
DMT can also be smoked, but the high heat (over 1500ºF or 900ºC) destroys a lot of the viable DMT and produces potentially harmful byproducts.
Vaping is considered safer, less harsh on the throat and lungs, and more efficient than smoking.
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DMT Vape Pens: Pros and Cons

The flood of DMT vape pens on the market is inevitable, and while a lot of psychedelic experts bring up some very serious cautions regarding their use among the general public — they’re here to stay.
Rather than fighting the inevitable, we believe it’s more important to educate users to reduce the potential for harm.
Treating these pens with respect and moderation is critical to avoiding potentially life-altering consequences. DMT is a powerful psychedelic substance with a wide capacity for healing and harm.
The vape pen version of DMT makes it much easier to use and allows users to “dial-in” the intensity of effects by regulating how many hits they take. Many modern psychedelic facilitators that work with DMT use vape pens for this reason.
While DMT isn’t inherently addictive, providing it as a vape makes it much easier to abuse the substance. Vapes are already widely available for other substances. It’s common for people to use vape pens compulsively rather than for any potential
medicinal or therapeutic benefits.
There are accounts of people on Reddit who claim to be using DMT vape pens every day, sometimes a few times per day. This is not a safe way to use this substance and the long-term physical and mental side effects of this is still unknown.
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What Are the Benefits of DMT Vape Pens?
• Simple to use — Breakthrough experiences are available to virtually everybody. When used responsibly, this may offer a substantial capacity for healing.
• Ability to control the dose — By regulating how many hits you take and the amount of time you hold the vapor in your lungs, you can control the intensity of effects with a reasonable degree of accuracy.
• Less harsh on your throat and lungs than smoking — Let’s be clear, vaping DMT is going to be harsh, but it’s far less harsh than smoking DMT.
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What Are the Negatives of DMT Vape Pens?
• Potential for abuse — vape pens are very easy to use too often and can become habit-forming.
• Expensive — DMT is expensive, so whether you’re using a vape or smoking it, the price will be fairly high.
• Potential health risks — DMT requires high heat to vaporize and can be harsh on the throat and lungs.
• Highly illegal — DMT is a controlled substance in the United States and many other countries worldwide.
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How to Use a DMT Vape Pen
The whole point of a DMT vape is that it’s simple to use. Nevertheless, there are a few steps to follow to get the most efficient hit from your vape.
Step 1: Shake the Pen
Always give the pen a good shake before you use it. The DMT will tend to separate from the e-liquid base, so if you skip this step, you will either get a hit of pure DMT or pure e-liquid.
Step 2: Take one Long Inhale, and Exhale Completely
This does two things; it calms you down before the hit, which is going to help reduce the chances of having a challenging or anxious experience. Secondly, it prepares you to take a longer, deeper breath during the next step, ultimately making the DMT
more efficient.
Step 3: Take a Deep Inhale
Don’t rush it — inhale the vapor from the device slowly. It’s going to be pretty harsh, so taking longer, slower breaths will cut back on some of this harshness. Once you’ve taken a full inhale, release the pen and take one more inhale to bring
all the vapor into the lungs.
Step 4: Hold Your Breath for a Few Seconds Before Exhaling
The DMT will immediately start absorbing through your lungs. Keeping the vapor in the lungs for a few seconds before exhaling allows you to get more efficiency from the DMT you’re using. The longer you hold your breath, the stronger the hit will be.
Step 5: Repeat as Necessary
Depending on the potency of your pen, the amount of vapor you inhaled, and the time you held the vapor in your lungs, you may need to take a few hits to reach breakthrough levels.
For a standard 400 mg, 0.5 mL vape cartridge, you may need between 5 and 15 hits to reach this effect level.
If using a mesh pen or stronger vape cartridge, you may only need 1–3 hits to reach breakthrough levels, so don’t rush it.
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How Strong Are DMT Vape Pens?
Few psychedelics compete in terms of the depth of psychedelic experience than a DMT vape pen. They’re comparable in strength to ayahuasca but have substantially higher celerity.
Celerity is a term that describes the speed at which the psychedelic state of consciousness appears and disappears again.
Think “acceleration.” The faster a psychedelic accelerates, the sooner the race is over.
DMT vape pens are like a drag car — capable of reaching top speed almost instantly. But this comes at a cost — drag cars burn through their fuel quickly.
Substances with low celerity, like ayahuasca, take longer to get up to speed (reach peak effects) but also last much longer (6–10 hours). Ayahuasca is like a rally car — it’s much slower off the line but has the efficiency and fuel capacity to run
for several hours.
A single hit of a vape pen can inject the user into deep psychedelic states in a matter of just a few seconds. The effects usually reach peak experience by the 10-minute mark and quickly fade out from there.
Just as fast as the experience begins, it goes away again. The total experience from a DMT vape pen rarely lasts longer than 30 minutes in total.
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