Light therapy helps burn injuries heal faster by triggering growth
protein

Date:
August 6, 2021
Source:
University at Buffalo
Summary:
The research found that photobiomodulation -- a form of low-dose
light therapy -- sped up recovery from burns and reduced
inflammation in mice by activating a protein that controls cell
growth and division.



FULL STORY ========================================================================== Light therapy may accelerate the healing of burns, according to a
University at Buffalo-led study.


==========================================================================
The research, published in Scientific Reports, found that
photobiomodulation therapy -- a form of low-dose light therapy capable
of relieving pain and promoting healing and tissue regeneration -- sped
up recovery from burns and reduced inflammation in mice by activating endogenous TGF-beta 1, a protein that controls cell growth and division.

The findings may impact therapeutic treatments for burn injuries,
which affect more than 6 million people worldwide each year, says lead investigator Praveen Arany, DDS, PhD, assistant professor of oral biology
in the UB School of Dental Medicine.

"Photobiomodulation therapy has been effectively used in supportive
cancer care, age-related macular degeneration and Alzheimer's disease,"
says Arany. "A common feature among these ailments is the central
role of inflammation. This work provides evidence for the ability of photobiomodulation-activated TGF-beta 1 in mitigating the inflammation,
while promoting tissue regeneration utilizing an elegant, transgenic
burn wound model." The study measured the effect of photobiomodulation
on the closure of third- degree burns over a period of nine days.

The treatment triggered TGF?beta 1, which stimulated various cell types involved in healing, including fibroblasts (the main connective tissue
cells of the body that play an important role in tissue repair) and
macrophages (immune cells that lower inflammation, clean cell debris
and fight infection).

The researchers also developed a precise burn healing protocol for photobiomodulation treatments to ensure additional thermal injuries are
not inadvertently generated by laser use.

The effectiveness of photobiomodulation in treating pain and stimulating healing has been documented in hundreds of clinical trials and
thousands of academic papers. The therapy was recently recommended as a standard treatment for pain relief from cancer-associated oral mucositis (inflammation and lesions in the mouth) by the Multinational Association
for Supportive Care in Cancer.

Additional investigators on the study include Imran Khan, PhD, first
author and staff scientist at the National Cancer Institute; Saeed Ur
Rahman, PhD, assistant professor at Khyber Medical University, Peshawar;
Elieza Tang, DDS, dentist; Karl Engel, senior field clinical specialist
at Abbott; and Bradford Hall, PhD, staff scientist, and Ashok Kulkarni,
PhD, senior investigator, both at the National Institute of Dental and Craniofacial Research.

========================================================================== Story Source: Materials provided by University_at_Buffalo. Original
written by Marcene Robinson. Note: Content may be edited for style
and length.


========================================================================== Journal Reference:
1. Imran Khan, Saeed Ur Rahman, Elieza Tang, Karl Engel, Bradford Hall,
Ashok B. Kulkarni, Praveen R. Arany. Accelerated burn wound
healing with photobiomodulation therapy involves activation of
endogenous latent TGF- b1. Scientific Reports, 2021; 11 (1) DOI:
10.1038/s41598-021-92650-w ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2021/08/210806104325.htm

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