Combining certain meds with ibuprofen can permanently injure kidneys
Commonly prescribed hypertension drugs may be harmful in combination with ibuprofen

Date:
May 5, 2022
Source:
University of Waterloo
Summary:
Anyone who is taking a diuretic and a renin-angiotensin system
(RSA) inhibitor for high blood pressure should be cautious about
also taking ibuprofen, according to new research.



FULL STORY ========================================================================== Anyone who is taking a diuretic and a renin-angiotensin system (RSA)
inhibitor for high blood pressure should be cautious about also taking ibuprofen, according to new research.


========================================================================== Diuretics and RSA inhibitors are commonly prescribed together for people
with hypertension and are available under various pharmaceutical brand
names.

Painkillers such as ibuprofen are available over-the-counter in most
pharmacies and stores in popular brands.

Researchers at the University of Waterloo used computer-simulated drug
trials to model the interactions of the three drugs and the impact on
the kidney. They found that in people with certain medical profiles,
the combination can cause acute kidney injury, which in some cases can
be permanent.

"It's not that everyone who happens to take this combination of drugs
is going to have problems," said Anita Layton, professor of applied
mathematics at Waterloo and Canada 150 Research Chair in mathematical
biology and medicine.

"But the research shows it's enough of a problem that you should exercise caution." Computer-simulated drug trials can quickly produce results
that would take much longer in human clinical trials. Layton and her
team use mathematics and computer science to give medical practitioners
a head start with issues like drug complications.

The research, in this case, can also speak directly to the many people
who are taking drugs for hypertension and may reach for a painkiller
with ibuprofen without giving it much thought.

"Diuretics are a family of drugs that make the body hold less water,"
Layton said. "Being dehydrated is a major factor in acute kidney injury,
and then the RAS inhibitor and ibuprofen hit the kidney with this triple whammy. If you happen to be on these hypertension drugs and need a
painkiller, consider acetaminophen instead." Layton's new research
paper, with co-authors Jessica Leete, Carolyn Wang, and Francisco
J. Lo'pez-Herna'ndez, "Determining risk factors for triple whammy acute
kidney injury," appears in the journal Mathematical Biosciences.


========================================================================== Story Source: Materials provided by University_of_Waterloo. Note:
Content may be edited for style and length.


========================================================================== Journal Reference:
1. Jessica Leete, Carolyn Wang, Francisco J. Lo'pez-Herna'ndez,
Anita T.

Layton. Determining risk factors for triple whammy acute kidney
injury.

Mathematical Biosciences, 2022; 347: 108809 DOI: 10.1016/
j.mbs.2022.108809 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/05/220505085618.htm

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