New research could help identify babies at risk of brain bleeds

Date:
May 2, 2022
Source:
Walter and Eliza Hall Institute
Summary:
Researchers have uncovered a new way to help identify babies and
fetuses at high-risk of developing brain bleeds, paving the way
for better early intervention.



FULL STORY ========================================================================== Researchers from WEHI (the Walter and Eliza Hall Institute) have uncovered
a new way to help identify babies and foetuses at high-risk of developing
brain bleeds, paving the way for better early intervention.


========================================================================== Brain bleeds in unborn babies and newborns can lead to stroke and
permanent neurological conditions, such as cerebral palsy.

While brain bleeds can sometimes be treated with platelet transfusions,
the invasive procedures can be dangerous, and it had been unclear which
babies would benefit most.

At a glance
* Research finds a new way to help identify unborn and newborn
babies at
risk of brain bleeds.

* Preclinical studies show brain bleeds will occur if platelet
levels drop
to 10 per cent or below in foetuses and newborns.

* The new threshold could be used to determine which babies should
have
treatment, transforming platelet transfusion practises and avoiding
unnecessary procedures.

WEHI researchers Dr Alison Farley and Dr Samir Taoudi are investigating
how levels of platelets, small blood cells best known for enabling blood
clots, affect brain bleeds to better understand when platelet transfusion should be deployed.

A new analysis of preclinical models has found brain bleeds always
occurred when platelet levels dropped to 10 per cent or below in newborns
and foetuses.



==========================================================================
The research also indicates that babies may develop protection against
brain bleeds two weeks after birth, with bleeding no longer triggered
by very low platelet levels beyond this age.

Published in Blood, the study paves the way to better understanding
which babies should receive a platelet transfusion and where the platelet threshold could be set to, in order to avoid unnecessary transfusions.

Platelet counts Low platelet levels, a condition known as
thrombocytopenia, can be associated with excessive bleeding and is common
in preterm infants.

By analysing varying degrees of thrombocytopenia in pre-clinical models, researchers were able to distinguish three levels of platelet counts
that determined brain bleed risk.



==========================================================================
They found brain bleeds in unborn or newborn babies were guaranteed if
their platelet count dropped to 10 per cent or below.

While a moderate platelet level between 10-40 per cent could potentially trigger a brain bleed, babies with over 40 per cent of platelets weren't
at risk of developing the condition at all.

"Platelet transfusions are currently given to babies in that moderate
range, who may not even experience brain bleeds," Dr Farley said.

"Working out the thresholds of platelet levels that will always lead to
brain bleeds, and the range that may not, is critical.

"Our findings could help determine which babies can safely receive
a platelet transfusion after birth, and where the threshold could be
lowered to avoid unnecessary and risky transfusions.

"If the loss of platelets occurs within days after birth, then this
could offer a window for potential intervention, to prevent severe brain
bleeds and stroke in babies." Building resistance Dr Samir Taoudi said analysing why protection against brain bleeds forms two weeks after
birth would be an important next step, as well as investigating which
proteins and genes are involved.

"We need to see how, or even if, platelets and brain blood vessels work together to build resistance to brain bleeds," Dr Taoudi said.

"Our next big challenge is to understand if brain bleeds are caused by
a communication breakdown between platelets and blood vessels, or if
they are being triggered by environmental factors?" This research was supported by the Cerebral Palsy Alliance, a Speedy Innovation Grant, the National Health and Medical Research Council, the Australian Research
Council's Stem Cells Australia program, the Australian Cancer Research Foundation, the Lorenzo and Pamela Galli Charitable Trust and the
Victorian Government.


========================================================================== Story Source: Materials provided by Walter_and_Eliza_Hall_Institute. Note: Content may be edited for style and length.


========================================================================== Journal Reference:
1. Alison M. Farley, Merle Dayton, Christine Biben, Olivia Stonehouse,
Antoine Terreaux, Samir Taoudi. Cerebral vasculature exhibits
dose- dependent sensitivity to thrombocytopenia that is limited
to fetal/ neonatal life. Blood, 2022; 139 (15): 2355 DOI:
10.1182/blood.2021014094 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/05/220502120450.htm

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