Evidence from a randomized clinical trial shows broad-spectrum
micronutrient supplementation with all known vitamins and essential minerals resulted in global improvement of attention and mood based on blinded clinician ratings

Date:
April 26, 2022
Source:
Elsevier
Summary:
A study reports that children with ADHD and emotional dysregulation
randomized to take a micronutrient formula were three times more
likely to show symptomatic improvement on blinded clinician
ratings, compared to those in the placebo group (54% versus
18%). The micronutrient formula, consisting of all known vitamins
and essential minerals, was administered for eight weeks.



FULL STORY ==========================================================================
A study in theJournal of the American Academy of Child and Adolescent Psychiatry(JAACAP), published by Elsevier, reports that children with
ADHD and emotional regulation randomized to take a micronutrient formula
were three times more likely to show symptomatic improvement on blinded clinician ratings, compared to those in the placebo group (54% versus
18%). The micronutrient formula, consisting of all known vitamins and
essential minerals, was administered for eight weeks.


========================================================================== "Supplementing with all known vitamins and essential minerals, at doses
between Recommended Daily Allowance and Upper Tolerable Limit, may improve
mood and concentration in children with ADHD and emotional dysregulation,"
said lead author Jeanette Johnstone, PhD, Assistant Professor, Department
of Child and Adolescent Psychiatry, Oregon Health & Science University
and Helfgott Research Institute, National University of Natural Medicine.

"These findings, replicating results of a previous randomized trial of micronutrients in children with ADHD conducted in New Zealand, confirm
that supplementation with a broad range of nutrients may benefit some
children.

These findings may offer guidance to doctors and families seeking
integrative treatments for their children with ADHD and related emotional dysregulation," Dr. Johnstone noted.

The triple-blinded study enrolled 135 medication-free children and their parents at three sites (Portland, Oregon; Columbus, Ohio; Alberta, Canada)
and randomized participants to either micronutrient or placebo capsules
for eight weeks. Three-quarters of the participants were adherent to
the study protocol.

The intervention was well-tolerated, with no significant differences in
adverse events between the micronutrient and placebo groups, or safety
concerns based on blood and urine tests. Parents, children and clinicians
were blinded to treatment allocation and were not able to guess assignment better than chance.

In addition to behavioral and emotional benefits, children taking micronutrients grew 6mm more in height than those taking placebo after adjusting for baseline height. "The growth finding, also a replication
from the previous child micronutrient study, is particularly encouraging,
as height suppression is a concern with first-line ADHD medication,"
Dr. Johnstone added.

In contrast to clinician ratings, parents, who were also blinded to their child's treatment allocation, reported significantly improved behavior
that was equal in both the micronutrient and placebo groups, with no significant between-group differences, highlighting the importance of
blinded clinician ratings.

"No treatment is 100% effective for all with ADHD," commented L. Eugene
Arnold, MD, Professor Emeritus of Psychiatry & Behavioral Health at Ohio
State University and one of the senior co-authors. "For example, about
2/3 respond to the first stimulant drug tried, which is an established first-line ADHD treatment despite emotional, appetite, and growth side
effects. So, it's encouraging that a good half of the children responded
to this relatively safe treatment." "Future studies will focus on the micronutrients' mechanisms of action and subgroup responses to understand
for whom and why this intervention works.

Mechanistic hypotheses to be tested include changes in the gut microbiome
and its metabolome, reductions in inflammatory markers (e.g. cytokines), replenishment of minerals, and optimization of neurotransmission. In
order to increase parent sensitivity to child behavior changes, we plan to utilize real- time data reporting methods such as 'ecological momentary assessment' using a phone or other device to capture behaviors when they occur," added Dr.

Johnstone.


========================================================================== Story Source: Materials provided by Elsevier. Note: Content may be edited
for style and length.


========================================================================== Journal Reference:
1. Jeanette M. Johnstone, Irene Hatsu, Gabriella Tost, Priya Srikanth,
Leanna P. Eiterman, Alisha M. Bruton, Hayleigh K. Ast, Lisa
M. Robinette, Madeline M. Stern, Elizabeth G. Millington, Barbara
L. Gracious, Andrew J. Hughes, Brenda M.Y. Leung, L. Eugene
Arnold. Micronutrients for Attention-Deficit/Hyperactivity Disorder
in Youths: A Placebo-Controlled Randomized Clinical Trial. Journal
of the American Academy of Child & Adolescent Psychiatry, 2022;
61 (5): 647 DOI: 10.1016/j.jaac.2021.07.005 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/04/220426101650.htm

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