Energy-burning brown fat less active in boys with obesity

Date:
April 14, 2022
Source:
McMaster University
Summary:
Researchers performed MRI scans to measure BAT activity in 26 boys
between the ages of eight and 10. They studied the BAT tissue in
the neck before and after one hour of exposure to a cold suit set
at a temperature of 18 degrees Celsius. The patient sample included
13 boys with a normal BMI and the same number again with obesity,
in the first study of its kind in children.



FULL STORY ==========================================================================
A study at McMaster University has found that brown adipose tissue (BAT)
is less active in boys with obesity compared to boys with a normal body
mass index (BMI).


========================================================================== Senior author Katherine Morrison said that BAT, also known as brown
fat, helps the body burn regular fat and is activated by cold, but her
research team noticed reduced BAT activity in the boys with obesity in
response to a cold stimulus.

The researchers of McMaster's Centre for Metabolism, Obesity and Diabetes Research performed MRI scans to measure BAT activity in 26 boys between
the ages of eight and 10. They studied the BAT tissue in the neck before
and after one hour of exposure to a cold suit set at a temperature of
18 degrees Celsius.

The patient sample included 13 boys with a normal BMI and the same number
again with obesity, in the first study of its kind in children.

"The promise of this study is that if we can better understand BAT and
how to mimic or stimulate its effects, it might offer us new therapies to
treat obesity," said Morrison, a professor in the university's Department
of Pediatrics and pediatrician at the McMaster Children's Hospital.

"Beyond helping families improve their nutrition, physical activity,
and sleep, we have few treatments to assist children and adolescents
with obesity. There are new medications that reduce appetite used in
some adolescents.

Investigating BAT activity holds out the hope of developing a new
class of drugs that increase the amount of energy you burn." However,
Morrison said that it is still unknown whether a lack of BAT activity
causes obesity, or if the condition simply impairs brown fat's ability
to burn energy.

She said that newborn babies have large amounts of BAT, but it steadily decreases through childhood, so that by adulthood it is mostly present
only in the neck region. The reason for decreasing brown fat levels in
children remains unknown.

Morrison said her team used MRI scans to measure BAT activity as it did
not expose the boys to ionizing radiation, unlike CT or PET scans. This potential safety risk has impeded research in children until now.

This study was funded by an internal grant from the Boris Family and
external funding for the study was provided by the Canadian Institutes
of Health Research.


========================================================================== Story Source: Materials provided by McMaster_University. Note: Content
may be edited for style and length.


========================================================================== Journal Reference:
1. Basma A. Ahmed, Nina Varah, Frank J. Ong, Denis P. Blondin,
Elizabeth
Gunn, Norman B. Konyer, Nina P. Singh, Michael D. Noseworthy,
Francois Haman, Andre C. Carpentier, Zubin Punthakee, Gregory
R. Steinberg, Katherine M. Morrison. Impaired Cold Stimulated
Supraclavicular Brown Adipose Tissue Activity in Young Boys with
Obesity. Diabetes, 2022; DOI: 10.2337/db21-0799 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/04/220414125028.htm

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