High cardiovascular risk is associated with symptoms of depression
Improving cardiovascular health might help prevent the onset of
depression in the elderly, researchers say

Date:
April 13, 2022
Source:
PLOS
Summary:
Cardiovascular risk factors are associated with an increased risk
of depression in older adults, according to a new study.



FULL STORY ========================================================================== Cardiovascular risk factors are associated with an increased risk of
depression in older adults, according to a new study published April
13 in the open-access journal PLOS ONE by Sandra Marti'n-Pela'ez of
University of Granada, Spain, and colleagues.


========================================================================== Cardiovascular disease and depression are thought to be closely related
due to similar risk factors, including inflammation and oxidative
stress. Although it has been shown that depression could be a risk factor
for developing cardiovascular disease, studies analyzing the potential
impact of cardiovascular health on developing depression are scarce.

In the new study, the researchers used data from an ongoing 6-year
multi-center randomized trial in Spain which analyzes the effect of a Mediterranean Diet on men aged 55-75 and women aged 60-75 with overweight
or obesity. 6,545 individuals with no cardiovascular or endocrine disease
at baseline were included in the current analysis. A cardiovascular risk
score according to the Framingham-based REGICOR function was calculated
for each person, dividing participants into low (LR), medium (MR), or
high/very high (HR) cardiovascular risk groups. Depressive status was
gauged using a questionnaire at baseline and after 2 years of follow-up.

At baseline, women in the HR group showed higher odds of depressive
status than LR women (OR 1.78 95% CI 1.26-2.50). In addition, among all participants with baseline total cholesterol below 160 mg/mL, MR and HR individuals showed higher odds of depression than LR (MR: OR 1.77 95%
CI 1.13-2.77; HR: OR 2.83 95% CI 1.25-6.42). On the contrary, among participants with total cholesterol of 280 mg/mL or higher, MR and HR individuals had a lower risk of depression than LR (MR: OR 0.26 95%
CI 0.07-0.98; HR: OR 0.23 95% CI 0.05-0.95). After two years, during
which time all individuals were instructed to follow a Mediterranean
Diet as part of the trial, participants, on average, decreased their
depressive status score, with the greatest decreases seen for MR and HR participants with high baseline cholesterol levels.

The authors conclude that high and very high cardiovascular risk are
associated with depressive symptoms, especially in women, and that the
role of other factors, such as adherence to the Mediterranean Diet,
deserves further research.

The authors add: "High cardiovascular risk, especially in women, is
associated with symptoms of depression in the elderly."

========================================================================== Story Source: Materials provided by PLOS. Note: Content may be edited
for style and length.


========================================================================== Journal Reference:
1. Sandra Marti'n-Pela'ez, Lluis Serra-Majem, Naomi Cano-Iba'n~ez,
Miguel
A'ngel Marti'nez-Gonza'lez, Jordi Salas-Salvado', Dolores
Corella, Camille Lassale, Jose Alfredo Marti'nez, A'ngel
M. Alonso-Go'mez, Julia Wa"rnberg, Jesu's Vioque, Dora Romaguera,
Jose' Lo'pez-Miranda, Ramo'n Estruch, Francisco J. Tinahones, Jose'
Lapetra, Fernando Ferna'ndez- Aranda, Aurora Bueno-Cavanillas, Josep
A. Tur, Vicente Marti'n, Xavier Pinto', Miguel Delgado-Rodri'guez,
Pilar Mati'a, Josep Vidal, Clotilde Va'zquez, Lidia Daimiel,
Emili Ros, Estefani'a Toledo, Stephanie K.

Nishi, Jose V. Sorli, Mireia Malcampo, M. A'ngeles Zulet,
Anai' Moreno- Rodri'guez, Raquel Cueto-Gala'n, Diego
Vivancos-Aparicio, Antoni Colom, Antonio Garci'a-Ri'os, Rosa
Casas, M Rosa Bernal-Lo'pez, Jose Manuel Santos-Lozano, Zenaida
Va'zquez, Carlos Go'mez-Marti'nez, Carolina Ortega-Azori'n,
Jose Lui's del Val, Itziar Abete, Amaia Goikoetxea-Bahon, Elena
Pascual, Nerea Becerra-Toma's, Juan J. Chillaro'n, Almudena
Sa'nchez-Villegas. Contribution of cardio-vascular risk factors to
depressive status in the PREDIMED-PLUS Trial. A cross-sectional and
a 2- year longitudinal study. PLOS ONE, 2022; 17 (4): e0265079 DOI:
10.1371/ journal.pone.0265079 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/04/220413141551.htm

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