Laser light, a dye and a nonsurgical implant could help overcome obesity


Date:
April 6, 2022
Source:
American Chemical Society
Summary:
When dieting and exercise aren't enough, weight-loss surgery can be
an effective obesity treatment. But people who don't want surgery
have other options, including insertion of an appetite-suppressing
balloon or other implant in the stomach. Now, researchers report
that they have augmented that procedure in laboratory animals by
coating an implant with a laser- activated dye that kills cells
producing ghrelin, the 'hunger hormone.'


FULL STORY ==========================================================================
When dieting and exercise aren't enough, weight-loss surgery can be an effective obesity treatment. But people who don't want surgery have other options, including insertion of an appetite-suppressing balloon or other implant in the stomach. Now, researchers report in ACS Applied Materials
& Interfaces that they have augmented that procedure in laboratory
animals by coating an implant with a laser-activated dye that kills
cells producing ghrelin, the "hunger hormone."

========================================================================== Implants can be inserted in the stomach through the mouth after local anesthesia. In 2019, Hwoon-Yong Jung, Jung-Hoon Park and colleagues
designed a new type of implant. The "intragastric satiety-inducing device" (ISD) consists of a stent -- which lodges in the lower esophagus --
attached to a disk that rests in the opening to the stomach. The disk
has a hole in the center to let food through. Tests in pigs showed that
the ISD lowered food intake and weight gain by enhancing the feeling of fullness and reducing levels of ghrelin, which is produced by cells near
the top of stomach. But the device caused complications, including acid
reflux and migration into the stomach. In their latest project, Jung,
Park, Kun Na and colleagues wanted to find out if they could suppress
ghrelin even more by coating the ISD's disk with a compound that, with a
shot of laser light, could kill some of the ghrelin-producing cells. The implant could then be removed to avoid the side effects associated with
the initial design.

In this preliminary study, the team coated ISDs with methylene blue --
an FDA- approved drug -- and then placed them in the stomachs of young
pigs. When exposed to laser light, the coating released singlet oxygen,
an energized form of oxygen that killed nearby ghrelin-producing cells
in the pigs' stomachs and then rapidly disappeared. After one week, the treatment reduced ghrelin levels and body weight gain by half compared
with an untreated pig, though these differences declined in the following
weeks unless the light treatment was repeated. With further development,
the simple procedure could become a new type of minimally invasive
treatment to help obese patients lose weight, the researchers say.

The authors acknowledge support from the Korea Medical Device
Development Fund grant funded by the Korean government (Project number: KMDF_PR_20200901_0036).


========================================================================== Story Source: Materials provided by American_Chemical_Society. Note:
Content may be edited for style and length.


========================================================================== Journal Reference:
1. Sanghee Lee, Ji Won Kim, Jinhwan Park, Hee Kyong Na, Do Hoon Kim,
Jin Hee
Noh, Dae Sung Ryu, Jae Myung Park, Jung-Hoon Park, Hwoon-Yong
Jung, Kun Na. Photodynamic Methylene Blue-Embedded Intragastric
Satiety-Inducing Device to Treat Obesity. ACS Applied Materials &
Interfaces, 2022; DOI: 10.1021/acsami.2c00532 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/04/220406101633.htm

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