Osmotic pressure and viscosity: Anticancer drug efficacy and restricting tumors using LDDS

Date:
March 29, 2022
Source:
Tohoku University
Summary:
Chemotherapy is known for its painful side-effects. It also has
limitations when the cancer has metastasized to the lymph nodes. The
lymphatic drug delivery system, where anticancer drugs are injected
directly into the sentinel lymph nodes under ultrasound guidance,
offers an alternative to conventional chemotherapy. Researchers
have now found the optimal osmotic pressure and viscosity ranges,
significantly improving the antitumor effect.



FULL STORY ========================================================================== Cancer often transfers from its primary lesion to other lesions --
clinically referred to as metastasis. In early metastasis, cancer cells
invade lymphatic vessels, reach lymph nodes, and proliferate. Conventional chemotherapy for metastatic lymph nodes has limitations because only part
of anticancer drug administrated by intravenous injection reaches the metastatic lymph nodes, and the expanded tumors restrict the bloodstream, preventing anticancer drug delivery.


==========================================================================
The lymphatic drug delivery system (LDDS) provides an alternative strategy
to conventional chemotherapy. Anticancer drugs are injected directly into sentinel lymph nodes under ultrasound guidance. LDDS is also available
during intra- operative or image-guided surgery.

Professor Tetsuya Kodama and assistant professor Ariunbuyan Sukhbaatar of
the Tohoku University Graduate School of Medical Engineering investigated
the effect of osmotic pressure and the viscosity of anticancer drugs on
the efficacy of lymph node metastasis treatment in collaboration with
Dr Shiro Mori of Tohoku University Hospital. The authors found that
optimal osmotic pressure and viscosity ranges significantly improved an antitumor effect.

This improvement could be explained as follows: the hyperosmotic
fluid injected into the tumor-draining lymph nodes may increase the
inflow of liquid components from blood vessels and high endothelial
venules. Anticancer drugs with higher osmotic fluid could also flow in the efferent lymphatic vessels and the case expansion of lymphatic channels
and vessels, allowing anticancer drugs to target tumor cells. Moreover,
the optimized anticancer drugs of LDDS could target not only sentinel
lymph nodes but also downstream lymph nodes with a high risk of secondary metastasis.

In summary, treatment using LDDS optimizes the physical properties
of anticancer drugs, osmotic pressure and viscosity; improves the
treatment efficacy; and restricts the spread of tumors in lymph node metastasis. It is anticipated these optimal ranges will be a starting
point for developing more effective drug regimens to treat metastatic
lymph nodes with the LDDS.


========================================================================== Story Source: Materials provided by Tohoku_University. Note: Content
may be edited for style and length.


========================================================================== Journal Reference:
1. Ariunbuyan Sukhbaatar, Shiro Mori, Tetsuya Kodama. Intranodal
delivery of
modified docetaxel: Innovative therapeutic method to inhibit
tumor cell growth in lymph nodes. Cancer Science, 2022; DOI:
10.1111/cas.15283 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/03/220329100021.htm

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