• Breakthrough hospitalizations 'extremely

    From ScienceDaily@1:317/3 to All on Tue Mar 22 22:30:44 2022
    Breakthrough hospitalizations 'extremely uncommon' after COVID-19
    immunity, study finds

    Date:
    March 22, 2022
    Source:
    Mayo Clinic
    Summary:
    Fewer than 1 in 1,000 people who have been vaccinated or previously
    infected with COVID-19 were hospitalized with a new breakthrough
    infection, research finds. The study supports previous studies
    that show vaccination is the best way to prevent severe COVID-19
    infection, hospitalization and death.



    FULL STORY ========================================================================== Fewer than 1 in 1,000 people who have been vaccinated or previously
    infected with COVID-19 were hospitalized with a new breakthrough
    infection, Mayo Clinic research finds. The study, which is published
    in Clinical Infectious Diseases, supports previous studies that show vaccination is the best way to prevent severe COVID-19 infection, hospitalization and death.


    ==========================================================================
    "In the general primary care patient population, those who have been
    vaccinated have very low risk of subsequent hospitalization for
    breakthrough COVID-19," says lead author Benjamin Pollock, Ph.D.,
    a researcher in the Mayo Clinic Robert D. and Patricia E. Kern Center
    for the Science of Health Care Delivery.

    "Our study shows that while it can and does happen, that these occurrences
    are extremely uncommon." The researchers created a longitudinal study
    of 106,349 primary care patients at Mayo Clinic in Rochester who were
    18 or older and tested positive for COVID- 19, and/or were vaccinated
    for COVID-19. Of those patients, only 69 were hospitalized because of
    a breakthrough COVID-19 infection.

    The researchers found the hospitalization rate was:
    * 0.06%, or 6 in 10,000 for vaccinated patients.

    * 0.03%, or 3 in 10,000, in previously infected but unvaccinated
    people.

    * 0.01%, or 1 in 10,000, among those who were both vaccinated and
    infected
    previously.

    While there were slight differences between the three groups, the
    researchers note the difference is not statistically significant.

    "We found these results to be in line with previous studies, although the interpretation shouldn't necessarily be that natural immunity provides
    the same protection as vaccination," says Dr. Pollock. "Rather, this
    study found that among our primary care population, both natural immunity
    and vaccine immunity appeared to lead to very low rates of breakthrough hospitalizations." The researchers looked at breakthrough cases that
    resulted in hospitalization, but they did not compare immunity after
    infection and vaccination rates among mild or asymptomatic breakthrough
    cases.



    ==========================================================================
    "We know that vaccination remains the safest route to protection from
    COVID-19 infection and severe disease," says Aaron Tande, M.D., a Mayo
    Clinic infectious diseases physician, and a co-author of the study. "I
    explain to my patients that a COVID-19 vaccine provides additional
    protection, even if they have been previously infected. For those who
    have not been infected, vaccination remains the safest and most reliable
    route of protection." Previous studies have shown similar results, the researchers note. Some studies have shown that immunity after infection prevents the most hospitalizations.

    Other studies have shown that vaccination prevents the most
    hospitalizations.

    In both cases, breakthrough hospitalizations are similarly rare.

    "Because it's impossible to tell in advance how severe a first infection
    may be, or who among vulnerable populations the virus may spread to,
    waiting for natural immunity is a gamble and not a safe alternative,"
    Dr. Tande says.

    The research was supported by the Mayo Clinic Robert D. and Patricia
    E. Kern Center for the Science of Health Care Delivery. The center's
    research focuses on transforming clinical practice. Its researchers seek
    to discover new ways to improve health; translate those discoveries
    into evidence-based, actionable treatments, processes and procedures;
    and apply this new knowledge to improve patient care.

    The senior author of the study is Priya Sampathkumar, M.D., a Mayo Clinic infectious diseases physician and head of Mayo's Infection Prevention
    and Control Program. In addition to Dr. Tande, the study's co-author is
    Curtis Storlie, Ph.D., a researcher in the Mayo Clinic Kern Center for
    the Science of Health Care Delivery.

    The research was funded by Mayo Clinic Robert D. and Patricia E. Kern
    Center for the Science of Health Care Delivery. The team reports no
    conflicts of interest.


    ========================================================================== Story Source: Materials provided by Mayo_Clinic. Original written by
    Adam Harringa. Note: Content may be edited for style and length.


    ========================================================================== Journal Reference:
    1. Benjamin D Pollock, Curtis B Storlie, Aaron J Tande, Priya
    Sampathkumar.

    Real-world incidence of breakthrough COVID-19 hospitalization after
    vaccination versus natural infection in a large, local, empaneled
    primary care population using time-to-event analysis. Clinical
    Infectious Diseases, 2022; DOI: 10.1093/cid/ciac186 ==========================================================================

    Link to news story: https://www.sciencedaily.com/releases/2022/03/220322130032.htm

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