• Even with statins, high triglycerides ma

    From ScienceDaily@1:317/3 to All on Wed Mar 16 22:30:44 2022
    Even with statins, high triglycerides may increase risk of second stroke


    Date:
    March 16, 2022
    Source:
    American Academy of Neurology
    Summary:
    Stroke can have many causes. An atherothrombotic stroke is caused
    by a clot that forms from plaques that build up within blood vessels
    in the brain. A new study suggests that people who have this type of
    stroke who also have higher levels of triglycerides, a type of fat,
    in their blood may have a higher risk of having another stroke or
    other cardiovascular problems one year later, compared to people who
    had a stroke but have lower triglyceride levels. The study found
    an association even when people were taking statin drugs meant to
    lower triglycerides and protect against heart attack and stroke.



    FULL STORY ========================================================================== Stroke can have many causes. An atherothrombotic stroke is caused by a
    clot that forms from plaques that build up within blood vessels in the
    brain. A new study suggests that people who have this type of stroke who
    also have higher levels of triglycerides, a type of fat, in their blood
    may have a higher risk of having another stroke or other cardiovascular problems one year later, compared to people who had a stroke but have
    lower triglyceride levels. The research is published in the March 16,
    2022, online issue of Neurology(R), the medical journal of the American
    Academy of Neurology. The study found an association even when people
    were taking statin drugs meant to lower triglycerides and protect against
    heart attack and stroke.


    ========================================================================== Elevated triglyceride levels are thought to contribute to hardening of
    the arteries and increased risk of heart attack, heart disease and stroke.

    "Our study suggests that for people who had atherothrombotic stroke,
    having elevated levels of triglycerides in their blood is a risk factor
    for having another stroke or other cardiovascular problems in the
    future, and we found that to be true even if the person is on statin
    therapy," said study author Takao Hoshino, MD, of the Tokyo Women's
    Medical University in Japan. "The good news is that statin medications
    are just one therapy for high triglycerides - - diet and exercise can
    also be effective ways to reduce the levels in your blood at little or
    no cost." The study looked at 870 people who had a stroke or transient ischemic attack.

    Their average age was 70. Of those, 217, or 25%, had elevated triglyceride levels, defined as fasting triglycerides levels 150 milligrams per
    deciliter or higher.

    Researchers followed up with the participants one year later to find
    out if there was an association between high triglyceride levels and
    having another stroke, acute coronary syndrome, which is any condition
    caused by a sudden reduction of blood flow to the heart, or death due
    to vascular causes.

    After adjusting for factors like cholesterol level and statin use,
    researchers found that people who had high triglyceride levels had a 21% greater risk of death, stroke or heart condition one year, compared to
    10% greater risk for those with lower levels.

    When researchers looked specifically at people who had another stroke
    after an atherothrombotic stroke, they found that 14 out of 114 people
    with normal triglyceride levels, or 12%, had one during the study,
    compared to 33 out of 217 people, or 16%, of those with elevated levels.

    For acute coronary syndrome, one out of 114 people, or 0.9%, with normal triglyceride levels developed the heart condition one year after an atherothrombotic stroke, compared to five out of 60, or 8%, of those
    with elevated levels.

    Hoshino notes the study did not find an association between higher
    triglyceride levels and future cardiovascular problems in people who
    had a different type of stroke called cardioembolic stroke.

    "More research is needed, but for people who have had an atherothrombotic stroke, triglyceride levels may emerge as a key target for preventing
    future strokes and other cardiovascular problems," Hoshino said. "Statin therapy is still an effective treatment for people with high triglyceride levels, but our study highlights how important it is to look at all
    the tools a person can use to lower their triglycerides, including diet modifications, exercise and taking omega-3 fatty acids." The study does
    not prove that lowering high triglyceride levels will prevent people
    with atherothrombotic strokes from having cardiovascular problems later;
    it only shows an association.

    A limitation of the study is that researchers considered only the
    participants' fasting levels of triglycerides.


    ========================================================================== Story Source: Materials provided by American_Academy_of_Neurology. Note: Content may be edited for style and length.


    ========================================================================== Journal Reference:
    1. Takao Hoshino, Kentaro Ishizuka, Sono Toi, Takafumi Mizuno, Ayako
    Nishimura, Sho Wako, Shuntaro Takahashi, Kazuo
    Kitagawa. Prognostic Role of Hypertriglyceridemia in Patients
    With Stroke of Atherothrombotic Origin. Neurology, 2022;
    10.1212/WNL.0000000000200112 DOI: 10.1212/ WNL.0000000000200112 ==========================================================================

    Link to news story: https://www.sciencedaily.com/releases/2022/03/220316173302.htm

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