History of neurological or psychiatric conditions increases the
likelihood of developing more
Date:
March 14, 2022
Source:
University of Waterloo
Summary:
People living with neurological or psychiatric conditions may
have an increased likelihood of having a second such condition
in the future, and their sex influences their risk, according to
new research.
FULL STORY ========================================================================== People living with neurological or psychiatric conditions may have an
increased likelihood of having a second such condition in the future,
and their sex influences their risk, according to new research.
==========================================================================
The study is Ontario's largest, both in population size and length of time studied, and was also the first to examine the effect that being a man
or woman has on the relationship between conditions. Researchers from
the University of Waterloo and the Institute for Clinical Evaluative
Science conducted the work with funding from the Neurodegenerative
Disease Research Initiative (ONDRI).
"Globally, neurological and psychiatric disorders are leading causes of disability and death," said Colleen Maxwell, a professor at the School of Pharmacy at Waterloo and lead author on the study. "Understanding which disorders or conditions are risk factors for, or early manifestations
of, later disorders will help health-care providers and family provide proactive care for individuals living with these conditions." Maxwell and
the study collaborators used provincial health databases to analyze data
from more than five million Ontario residents aged 40 to 85 years. Over
the course of 14 years, they examined the associations between pairs
of particularly common neurological conditions -- such as dementia,
Parkinson's disease, or stroke -- and psychiatric disorders like
depression and anxiety.
They explored the link between these conditions in both directions,
including investigating how the experience of previous stroke related
to future risk of dementia and vice versa. In almost all cases,
the researchers found that the rate of developing a second condition
increased. For example, individuals with prior Parkinson's disease had
four times the rate of developing dementia, while those with prior stroke
had more than double the rate of developing dementia.
They also found that having a psychiatric disorder previously was
associated with an increased rate of experiencing dementia later. For
some conditions, the risk of developing the second disorder remained
for 10 years or more after the first.
The team showed that women and men differed in their risk for developing a later condition after experiencing an earlier one. For example, comparing
men and women who experienced an earlier stroke, women were more likely
than their male counterparts to develop dementia later.
The researchers hope their work can inform not just the care that
individuals with these conditions receive directly, but also the planning
of the health system as a whole.
"We also hope to provide information for those designing medical,
educational programs to ensure health-care providers are informed of
and equipped to address these common comorbidities," Maxwell said.
The ONDRI supported the research through the Ontario Brain Institute. The
study was recently published in the journal Age and Aging.
========================================================================== Story Source: Materials provided by University_of_Waterloo. Note:
Content may be edited for style and length.
========================================================================== Journal Reference:
1. Colleen J Maxwell, Laura C Maclagan, Daniel A Harris, Xuesong
Wang, Jun
Guan, Ruth Ann Marrie, David B Hogan, Peter C Austin, Simone
N Vigod, Richard H Swartz, Susan E Bronskill. Incidence
of neurological and psychiatric comorbidity over time: a
population-based cohort study in Ontario, Canada. Age and Ageing,
2022; 51 (2) DOI: 10.1093/ageing/afab277 ==========================================================================
Link to news story:
https://www.sciencedaily.com/releases/2022/03/220314095719.htm
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