• Cancer cells change shape, how they move

    From ScienceDaily@1:317/3 to All on Wed Oct 27 21:30:30 2021
    Cancer cells change shape, how they move to invade different types of
    tissue

    Date:
    October 27, 2021
    Source:
    Oregon State University
    Summary:
    Research has shed new light on the way malignant cells change their
    shape and migration techniques to invade different types of tissue.



    FULL STORY ========================================================================== Oregon State University research has shed new light on the way malignant
    cells change their shape and migration techniques to invade different
    types of tissue.


    ==========================================================================
    The findings, published in Scientific Reports,are a key step toward understanding and preventing cancer metastasis, the internal spreading
    of the disease that's responsible for 95% of all cancer deaths.

    "Through billions of years of evolution, cells have learned a number
    of distinct ways to migrate," said OSU biophysicist Bo Sun, who led
    the study. "In normal development and health-maintaining physiological processes such as wound healing, specific migration programs are executed
    when required. In the case of a tumor, however, those migration programs
    are leveraged by cancer cells to sustain their invasion into tissue."
    How well a cancer cell can change shape and shift travel modes plays a
    huge role in a cancer patient's prognosis, Sun explains.

    "Many cancer therapies that target a particular way a cell moves can
    fail to stop tumor metastasis in large part because cells switch to
    another available migration program," he said.

    Sun and collaborators in the OSU colleges of Science and Engineering
    used a type of artificial intelligence known as computer vision to track
    a cell's migration program based on its shape; computer vision derives information from digital photos, video and other visual inputs.



    ==========================================================================
    For this study, the scientists looked at cells from MDA-MB-23, a line
    of highly invasive breast cancer cells that's commonly used in medical research. Sun likens the cell shape analysis to determining whether a
    swimmer is doing the backstroke, breaststroke or butterfly based on the position swimmers put their body in and the movements they execute.

    "Cell shape is determined by cell function, and loss of characteristic
    shape is associated with functional abnormality," Sun said. "That's
    why shape characterization has been an important tool for diagnosis in
    cancer as well as in other conditions such as red blood cell disease or neurological disorders." The findings show that cancer cells change their migration modes far more often than had been previously thought, he says.

    "While the constant switching we saw in the breast cancer cells we studied doesn't necessarily maximize their speed in a particular type of tissue,
    it allows for the cells to invade heterogeneous tissue environments,"
    Sun said.

    During metastasis, a migrating cancer cell has to make its way through extracellular matrix that has distinct and varying mechanical properties,
    the researchers note.



    ==========================================================================
    The extracellular matrix, or ECM, is the non-cellular part of tissues and organs. It acts as a scaffold and, thanks to its variety of biologically
    active molecules, performs a range of important biochemical and
    biomechanical jobs.

    The machine learning and visualization techniques the scientists employed showed that a cell's shape changes are regulated by the molecular
    control hub, Rho/ROCK-signaling, that a cell uses to sense its physical environment and generate the force required for motion.

    Using a model representing two mechanically distinct layers of
    extracellular matrix, the scientists showed the cells gradually changed
    their shape and movement program as they approached and crossed the
    interface of the layers.

    That suggests these transitions are essential for cancer cell metastasis,
    which requires the navigation of non-uniform ECM.

    "The way a cell's form changes -- its morphodynamics -- is a crucial
    factor in determining its invasive potential and to our knowledge this has largely gone unstudied," Sun said. "The morphodynamics of migrating cancer cells are shaping up to be a powerful tool for inspecting the internal
    state and microenvironment of the cells. Future research is needed to
    decode the morphodynamics into a rich and understandable body language
    of cells, and to affect morphodynamics as a means of controlling what the
    cells are doing." Collaborating with Sun were OSU colleagues Christopher
    Eddy, Helena Raposo, Aayushi Manchanda, Ryan Wong and Fuxin Li.

    The Gordon and Betty Moore Foundation, the National Science Foundation,
    the Department of Defense and the National Institute of General Medical Sciences funded the study.

    ========================================================================== Story Source: Materials provided by Oregon_State_University. Original
    written by Steve Lundeberg. Note: Content may be edited for style
    and length.


    ========================================================================== Journal Reference:
    1. Christopher Z. Eddy, Helena Raposo, Aayushi Manchanda, Ryan Wong,
    Fuxin
    Li, Bo Sun. Morphodynamics facilitate cancer cells to navigate
    3D extracellular matrix. Scientific Reports, 2021; 11 (1) DOI:
    10.1038/ s41598-021-99902-9 ==========================================================================

    Link to news story: https://www.sciencedaily.com/releases/2021/10/211027122001.htm

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